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Palladium-Catalyzed Regioselective C-H Functionalization/Annulation Reaction of Amides and Allylbenzenes for the Synthesis of Isoquinolinones and Pyridinones

期刊: JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (7)

A regioselective C-H functionalization/annulation reaction of N-sulfonyl amides and allylbenzenes through a palladium-catalyzed C(sp(2))-H allylation/......

An Environmentally Benign Cascade Reaction of 1,1-Enediamines (EDAMs) for Site-Selective Synthesis of Highly Functionalized 2,10-Dihydro-1H-imidazo[1 ',2 ':1,6]pyrido[2,3-b]indoles and Pyrroles

期刊: JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (8)

A novel protocol for the synthesis of pyrido[2,3-b]indoles (alpha-carbolines, 3) from (E)-3-(2-oxo-2-phenylethylidene) indolin-2-one derivatives 1 and......

Catalyst-Free [3+3] Annulation/Oxidation of Cyclic Amidines with Activated Olefins: When the Substrate Olefin Is Also an Oxidant

期刊: JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (11)

Herein we describe a catalyst-free regioselective [3 + 3] annulation/oxidation reaction of cyclic amidines such as DBU (1,8-diazabicyclo(5.4.0)undec-7......

Photocatalytic Approach for Construction of 5,6-Dihydroimidazo[2,1-a]isoquinolines and Their Luminescent Properties

期刊: JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (12)

A visible-light-driven photoredox reaction of tetrahydroisoquinoline with 2H-azirines is described. 4,7-Bis(4-methoxyphenyl)benzo[ c][1,2,5]thiadiazol......

Rapid and Effective Reaction of 2-Methylpyridin-N-oxides with Triphosgene via a [3,3]-Sigmatropic Rearrangement: Mechanism and Applications

期刊: JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (12)

A facile and effective synthesis of 2-chloromethylpyridines was developed by a one-pot reaction of 2-alkylpyridin-Noxides and triphosgene at room temp......

Direct para-Selective C-H Amination of Iodobenzenes: Highly Efficient Approach for the Synthesis of Diarylamines

期刊: JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (12)

Iodine(III)-mediated synthesis of 4-iodo-N-phenylaniline from iodobenzene has been achieved, and the reaction can proceed under mild conditions. A var......

Synthesis and Redox Properties of Water-Soluble Asymmetric Trityl Radicals

期刊: JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (12)

Tetrathiatriarylmethyl (trityl) radicals have been recently shown to react with biological oxidoreductants including glutathione (GSH), ascorbic acid ......

The Copper-Catalyzed Reaction of 2-(1-Hydroxyprop-2-yn-1-yl)phenols with Sulfonyl Azides Leading to C3-Unsubstituted N-Sulfonyl-2-iminocoumarins

期刊: JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (13)

An operationally simple synthesis of Z-configured and C3-unsubstituted N-sulfonyl- 2-iminocoumarins (e.g., 8a) that proceeds under mild conditions is ......

Diastereodivergent Synthesis of Chiral 4-Fluoropyrrolidines (exo and exo') Based on the Cu(II)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition

期刊: JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (13)

1,3-Dipolar cycloaddition of azomethine ylides and electron deficient alkenes is widely studied for rapid installation of pyrrolidine frameworks. Desp......

Amidation-Ketonization-Selenation of Terminal Alkynes Using TEMPO and Elemental Selenium

期刊: JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (14)

Herein, we present a novel silver- or copper-mediated direct amidation-ketonization-selenation of terminal allcynes for the synthesis of alpha-oxo-sel......

Diversity-Oriented Chemoenzymatic Synthesis of Sulfated and Nonsulfated Core 2 O-GalNAc Glycans

期刊: JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (15)

A diversity-oriented chemoenzymatic approach for the collective preparation of sulfated core 2 O-GalNAc glycans and their nonsulfated counterparts was......

Inactivation of Flavoenzyme-Encoding Gene flsO1 in Fluostatin Biosynthesis Leads to Diversified Angucyclinone Derivatives

期刊: JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (16)

Inactivation of the flavoenzyme-encoding gene flsO1 in fluostatin biosynthesis led to the isolation of four new angucyclinone derivatives (11, 12, 14,......

Metal-Free ortho-Selective C-H Borylation of 2-Phenylthiopyridines Using BBr3

期刊: JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (8)

A novel route for ortho-selective C-H borylation of 2-phenylthiopyridines using BBr3 as the boron source under metal-free conditions has been reported......

Regioselective Synthesis of 2,4-Diaryl-6-trifluoromethylated Pyridines through Copper-Catalyzed Cyclization of CF3-Ynones and Vinyl Azides

期刊: JOURNAL OF ORGANIC CHEMISTRY, 2021; 86 (9)

A novel copper-catalyzed cyclization of readily available vinyl azides with CF3-ynones is steadily achieved under mild conditions to furnish the versa......

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