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Disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea

期刊: PEDIATRIC INVESTIGATION, 2021; 5 (1)

Obstructive sleep apnea (OSA) is a common sleep-disordered breathing disease that often leads to many comorbidities (e.g., cognitive dysfunction), whi......

Childhood adiposity, adult adiposity, and bone health

期刊: PEDIATRIC INVESTIGATION, 2021; 5 (1)

ImportanceChildhood and adolescence are critical periods for lifelong bone mineral accrual, but few studies have determined the impact of childhood ad......

The impact of body weight trajectory from childhood on chronic inflammation in adulthood: The Bogalusa Heart Study

期刊: PEDIATRIC INVESTIGATION, 2021; 5 (1)

ImportanceThe impact of long-term burden of excessive body weight, beginning in childhood, on inflammatory status in adulthood has been poorly describ......

Can spot urine measurement be a substitute for 24-hour urine measurement to estimate sodium intake in adolescents?

期刊: PEDIATRIC INVESTIGATION, 2021; 5 (1)

ImportanceSeveral methods have been established in recent decades that allow use of spot urine to estimate dietary sodium intake. However, their accur......

Surgical correction for scimitar syndrome by right thoracotomy and direct anastomosis in children

期刊: PEDIATRIC INVESTIGATION, 2021; 5 (1)

ImportanceScimitar syndrome (SS) is a rare type of congenital heart disease characterized by total or partial anomalous venous drainage of the right l......

Characteristics of pediatric inpatients with primary and secondary hypertension

期刊: PEDIATRIC INVESTIGATION, 2021; 5 (1)

ImportanceExtensive population-based studies have explored the prevalence of primary hypertension (HTN) in children and adolescents. However, there is......

Intranasal glial heterotopia in an infant boy

期刊: PEDIATRIC INVESTIGATION, 2021; 5 (1)

IntroductionNasal glial heterotopia is a rare congenital developmental disorder characterized by meningeal epithelium and/or glial components. Case pr......

Pharmacokinetic variability of factor VIII concentrates in Chinese pediatric patients with moderate or severe hemophilia A

期刊: PEDIATRIC INVESTIGATION, 2021; 5 (1)

ImportanceThe use of factor VIII (FVIII) concentrates under pharmacokinetic (PK) guidance has become the main approach for treatment of hemophilia. Ho......

Upregulation of cadherin-11 contributes to cholestatic liver fibrosis

期刊: PEDIATRIC INVESTIGATION, 2022; 6 (2)

Importance: Cadherin-11 (CDH11), a cell-to-cell adhesion molecule, is implicated in the fibrotic process of several organs. Biliary atresia (BA) is a ......

Allogeneic hematopoietic stem cell transplantation with the modified myeloablative conditioning regimen for children with chronic active Epstein-Barr virus infection

期刊: PEDIATRIC INVESTIGATION, 2022; 6 (4)

Importance Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the only effective treatment for chronic active Epstein-Barr v......

Chinese patients with p.Arg756 mutations of ATP1A3: Clinical manifestations, treatment, and follow-up

期刊: PEDIATRIC INVESTIGATION, 2022; 6 (1)

Importance The phenotypes of ATP1A3 gene mutations are diverse. Relapsing encephalopathy with cerebellar ataxia and fever-induced paroxysmal weakness ......

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