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Pinocembrin flavanone inhibits cell viability in PC-3 human prostate cancer by inducing cellular apoptosis, ROS production and cell cycle arrest

期刊： ACTA PHARMACEUTICA, 2021; 71 (4)

The main purpose of the present study was to evaluate the antitumor effects of pinocembrin in human prostate cancer cells (PC-3) along with investigat......

Anticancer effects of 7,8-dihydromethysticin in human leukemia cells are mediated via cell-cycle dysregulation, inhibition of cell migration and invasion and targeting JAK/STAT pathway

期刊： ACTA PHARMACEUTICA, 2021; 71 (4)

The main focus of this research work was to study the anticancer properties of 7,8-dihydromethysticin against HL-60 leukemia cells. Investigations wer......

Recent advancements to enhance the therapeutic efficacy of antiepileptic drugs

期刊： ACTA PHARMACEUTICA, 2021; 71 (4)

Epilepsy is a multifactorial neurological disorder characterized by recurrent or unprovoked seizures. Over the past two decades, many new antiepilepti......

Pharmacokinetics study of a supersaturatable self-microemulsifying drug delivery system for ellagic acid by UHPLC-Q-TOF-MS

期刊： ACTA PHARMACEUTICA, 2021; 71 (4)

To evaluate the bioavailability of ellagic acid loaded super-saturatable self-microemulsifying drug delivery system (S-SMEDDS), its pharmacokinetic pr......

Identification and pharmacokinetics of saponins in Rhizoma Anemarrhenae after oral administration to rats by HPLC- Q-TOF/MS and HPLC-MS/MS

期刊： ACTA PHARMACEUTICA, 2021; 71 (4)

Rhizoma Anemarrhenae is a well-known herbal medicine with saponins as its commonly regarded major bioactive components. It is essential to classify th......

Improved 11 alpha-hydroxycanrenone production by modification of cytochrome P450 monooxygenase gene in Aspergillus ochraceus

期刊： ACTA PHARMACEUTICA, 2021; 71 (1)

Eplerenone is a drug that protects the cardiovascular system. 11 alpha-Hydroxycanrenone is a key intermediate in eplerenone synthesis. We found that a......

Norcantharidin induces G2/M arrest and apoptosis via activation of ERK and JNK, but not p38 signaling in human renal cell carcinoma ACHN cells

期刊： ACTA PHARMACEUTICA, 2021; 71 (2)

Renal cell carcinoma (RCC) is generally acknowledged as the most resistant primary malignancy unresponsive to conventional radiotherapy and chemothera......

Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment

期刊： ACTA PHARMACEUTICA, 2021; 71 (2)

Tryptanthrin is an indole quinazoline alkaloid from the indigo-bearing plants, such as Isatis indigotica Fort. Typically, this natural compound shows ......

Amygdalin isolated from Amygdalus mongolica protects against hepatic fibrosis in rats

期刊： ACTA PHARMACEUTICA, 2021; 71 (3)

The aim of this research was to investigate the effect of amygdalin on hepatic fibrosis in rats. Amygdalin was purified and identified from the seeds ......

Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits

期刊： ACTA PHARMACEUTICA, 2021; 71 (3)

Our study evaluates the effects of sacubitril/valsartan (SAC/VAL) in the rabbit model of doxorubicin-induced heart failure. Twenty rabbits (5 per grou......

Quantitative analysis and pharmacokinetic study of a novel diarylurea EGFR inhibitor (ZCJ14) in rat plasma using a validated LC-MS/MS method

期刊： ACTA PHARMACEUTICA, 2021; 71 (3)

1-(4-(Pyrrolidin-1-yl-methyl)phenyl)-3-(4-((3-(trifluoromethyl) phenyl)amino)quinazolin-6-yAl)urea (ZCJ14), a novel epidermal growth factor receptor (......

Prediction of drug-drug plasma protein binding interactions of resveratrol in combination with celecoxib and leflunomide by molecular docking combined with an ultrafiltration technique

期刊： ACTA PHARMACEUTICA, 2020; 70 (1)

The present study is aimed at computational prediction of the molecular interactions between resveratrol, celecoxib, leflunomide and human serum album......

Beneficial effects of baicalein on a model of allergic rhinitis

期刊： ACTA PHARMACEUTICA, 2020; 70 (1)

Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an ......

Curcumin-loaded nanostructured lipid carrier induced apoptosis in human HepG2 cells through activation of the DR5/caspase-mediated extrinsic apoptosis pathway

期刊： ACTA PHARMACEUTICA, 2020; 70 (2)

Curcumin is a lipophilic anti-cancer compound extracted from turmeric. Our previous study demonstrated that the curcumin-loaded nanostructured lipid c......

SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1

期刊： ACTA PHARMACEUTICA, 2020; 70 (2)

The incidence of mortality of prostate cancer (PCa) has been an uptrend in recent years. Our previous study showed that the sex-determining region Y-b......

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