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Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1/miR-194/SIRT1 signaling pathway

期刊: JOURNAL OF INFLAMMATION-LONDON, 2021; 18 (1)

Background Liver injury seriously threatens the health of people. Meanwhile, dexmedetomidine hydrochloride (DEX) can protect against liver injury. How......

USP10 alleviates sepsis-induced acute kidney injury by regulating Sirt6-mediated Nrf2/ARE signaling pathway

期刊: JOURNAL OF INFLAMMATION-LONDON, 2021; 18 (1)

Background Severe sepsis, a major health problem worldwide, has become one of the leading causes of death in ICU patients. Further study on the pathog......

VEGF as a potential molecular target in periodontitis: a meta-analysis and microarray data validation

期刊: JOURNAL OF INFLAMMATION-LONDON, 2021; 18 (1)

Background Anti-vascular endothelial growth factor (VEGF) has been used as a therapeutic drug for the treatment of some human diseases. However, no sy......

Luteolin transforms the polarity of bone marrow-derived macrophages to regulate the cytokine storm

期刊: JOURNAL OF INFLAMMATION-LONDON, 2021; 18 (1)

Background Macrophages are indispensable regulators of inflammatory responses. Macrophage polarisation and their secreted inflammatory factors have an......

Bullatacin triggers immunogenic cell death of colon cancer cells by activating endoplasmic reticulum chaperones

期刊: JOURNAL OF INFLAMMATION-LONDON, 2021; 18 (1)

Background It is well accepted that the immune system efficiently contributes to positive outcomes of chemotherapeutic cancer treatment by activating ......

Impact of NF-kappa B pathway on the intervertebral disc inflammation and degeneration induced by over-mechanical stretching stress

期刊: JOURNAL OF INFLAMMATION-LONDON, 2021; 18 (1)

BackgroundIntervertebral disk degeneration (IVDD) contributes to low back pain. Increased cell apoptosis and inflammation, decreased extracellular mat......

Lactobacillus fermentum CQPC07 attenuates obesity, inflammation and dyslipidemia by modulating the antioxidant capacity and lipid metabolism in high-fat diet induced obese mice

期刊: JOURNAL OF INFLAMMATION-LONDON, 2021; 18 (1)

BackgroundObesity is an epidemic disease in the world, the treatment and prevention of obesity methods have gained great attention. Lactobacillus is t......

Dendritic cells transduced with TIPE-2 recombinant adenovirus induces T cells suppression

期刊: JOURNAL OF INFLAMMATION-LONDON, 2021; 18 (1)

Introduction TIPE-2 has been identified as a negative regulator of both innate and adaptive immunity and is involved in several inflammatory diseases.......

Pellino1 promoted inflammation in lung injury model of sepsis by TRAF6/ NF-kappa B signal pathway

期刊: JOURNAL OF INFLAMMATION-LONDON, 2021; 18 (1)

Background This study was designed to investigate the role of Pellino1 in lung injury model of sepsis and its anti-inflammation mechanism. Method: C57......

LncRNA TUG1 regulates the development of ischemia-reperfusion mediated acute kidney injury through miR-494-3p/E-cadherin axis

期刊: JOURNAL OF INFLAMMATION-LONDON, 2021; 18 (1)

Background Acute kidney injury (AKI) results from renal dysfunction caused by various causes, resulting in high mortality. The underlying mechanisms o......

Overexpression of SP1 restores autophagy to alleviate acute renal injury induced by ischemia-reperfusion through the miR-205/PTEN/Akt pathway

期刊: JOURNAL OF INFLAMMATION-LONDON, 2021; 18 (1)

Background Acute kidney injury (AKI) is a major kidney disease with poor clinical outcome. SP1, a well-known transcription factor, plays a critical ro......

MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1 alpha/PPAR-gamma pathway

期刊: JOURNAL OF INFLAMMATION-LONDON, 2021; 18 (1)

Background Sepsis is a complex syndrome characterized by a dysregulated inflammatory response to systemic infection and leads to shock, multiple organ......

Dexamethasone can attenuate the pulmonary inflammatory response via regulation of the lncH19/miR-324-3p cascade

期刊: JOURNAL OF INFLAMMATION-LONDON, 2021; 18 (1)

Objective: To investigate lncRNAs and their roles in regulating the pulmonary inflammatory response under dexamethasone (Dex) treatment. Methods: IL-1......

Effects of long non-coding RNA Gm14461 on pain transmission in trigeminal neuralgia

期刊: JOURNAL OF INFLAMMATION-LONDON, 2020; 17 (1)

Background This study aims to investigate the role of long non-coding RNA Gm14461 in regulating pain transmission in trigeminal neuralgia (TN). The mo......

Corpus cavernosum smooth muscle cell dysfunction and phenotype transformation are related to erectile dysfunction in prostatitis rats with chronic prostatitis/chronic pelvic pain syndrome

期刊: JOURNAL OF INFLAMMATION-LONDON, 2020; 17 (1)

Background The relationship between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and erectile dysfunction (ED) has been shown in many st......

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