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Distribution of intra-host variations and mutations in the genomes of SARS-CoV-2 and their implications on detection and therapeutics

期刊: MEDCOMM, 2022; 3 (4)

The ongoing circulation of SARS-CoV-2 variants of concern (VOCs) has caused global concerns, because VOCs could escape current vaccines, antiviral dru......

Low hemoglobin is associated with worse outcomes via larger hematoma volume in intracerebral hemorrhage due to systemic disease

期刊: MEDCOMM, 2022; 3 (1)

Whether hemoglobin is associated with outcomes of a specific subtype of intracerebral hemorrhage (ICH) is unknown. A total of 4643 patients with ICH f......

Different subpopulations of regulatory T cells in human autoimmune disease, transplantation, and tumor immunity

期刊: MEDCOMM, 2022; 3 (2)

CD4(+)CD25(+) regulatory T cells (Tregs), a subpopulation of naturally CD4(+) T cells that characteristically express transcription factor Forkhead bo......

Tyrosine phosphatase SHP2 exacerbates psoriasis-like skin inflammation in mice via ERK5-dependent NETosis

期刊: MEDCOMM, 2022; 3 (1)

Psoriasis is a chronic inflammatory skin disease, often accompanied by increased infiltration of immune cells, especially neutrophils. However, the de......

Role of chemokine systems in cancer and inflammatory diseases

期刊: MEDCOMM, 2022; 3 (2)

Chemokines are a large family of small secreted proteins that have fundamental roles in organ development, normal physiology, and immune responses upo......

Characteristic analysis of Omicron-included SARS-CoV-2 variants of concern

期刊: MEDCOMM, 2022; 3 (2)

In view of the rapid development of the COVID-19 pandemic and SARS-CoV-2 mutation, we characterized the emerging SARS-CoV-2 variants of concern (VOCs)......

Integrated analyses of brain and platelet omics reveal their common altered and driven molecules in Alzheimer's disease

期刊: MEDCOMM, 2022; 3 (4)

Platelets may serve as a perfect peripheral source for exploring diagnostic biomarkers for Alzheimer's disease (AD); however, the molecular linkage be......

Signaling pathways in the regulation of cancer stem cells and associated targeted therapy

期刊: MEDCOMM, 2022; 3 (4)

Cancer stem cells (CSCs) are defined as a subpopulation of malignant tumor cells with selective capacities for tumor initiation, self-renewal, metasta......

Trained immunity: A Yin-Yang balance

期刊: MEDCOMM, 2022; 3 (1)

Traditionally, immune memory is regarded as an exclusive hallmark of adaptive immunity. However, a growing body of evidence suggesting that innate imm......

STAT3 pathway in cancers: Past, present, and future

期刊: MEDCOMM, 2022; 3 (2)

Signal transducer and activator of transcription 3 (STAT3), a member of the STAT family, discovered in the cytoplasm of almost all types of mammalian ......

SENP3-mediated TIP60 deSUMOylation is required for DNA-PKcs activity and DNA damage repair

期刊: MEDCOMM, 2022; 3 (2)

The activation of DNA-dependent kinase (DNA-PKcs) upon DNA damage contains a cascade of reactions, covering acetylation by TIP60, binding with Ku70/80......

The molecular pathophysiology of depression and the new therapeutics

期刊: MEDCOMM, 2022; 3 (3)

Major depressive disorder (MDD) is a highly prevalent and disabling disorder. Despite the many hypotheses proposed to understand the molecular pathoph......

Programmed death-ligand 1 expression on CD22-specific chimeric antigen receptor-modified T cells weakens antitumor potential

期刊: MEDCOMM, 2022; 3 (2)

The molecules of programmed cell death protein-1 (PD-1) and ligand-1 (PD-L1) become new therapeutic targets for cancer therapy. Although tumor-express......

Cryo-EM structure of G-protein-coupled receptor GPR17 in complex with inhibitory G protein

期刊: MEDCOMM, 2022; 3 (4)

GPR17 is a class A orphan G protein-coupled receptor (GPCR) expressed in neurons and oligodendrocyte progenitors of the central nervous system (CNS). ......

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