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Machine learning-aided protein identification from multidimensional signatures

期刊: LAB ON A CHIP, 2021; 21 (15)

The ability to determine the identity of specific proteins is a critical challenge in many areas of cellular and molecular biology, and in medical dia......

Cell-sorting centrifugal microfluidic chip with a flow rectifier

期刊: LAB ON A CHIP, 2021; 21 (11)

Centrifugal microfluidic chips offer rapid, highly integrable and simultaneous multi-channel microfluidic control without relying on external pressure......

Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out

期刊: LAB ON A CHIP, 2021; 21 (15)

With its origin estimated around December 2019 in Wuhan, China, the ongoing SARS-CoV-2 pandemic is a major global health challenge. The demand for sca......

Analyzing protein-protein interactions in rare cells using microbead-based single-molecule pulldown assay

期刊: LAB ON A CHIP, 2021; 21 (16)

For studying protein-protein interactions (PPIs) in general, a powerful and commonly used technique is conventional coimmunoprecipitation (co-IP/pulld......

Microfluidic-directed biomimetic Bulbine torta-like microfibers based on inhomogeneous viscosity rope-coil effect

期刊: LAB ON A CHIP, 2021; 21 (13)

Helical structures are attracting increasing attention owing to their unique typical physical and chemical properties. However, it remains a challenge......

Sensing morphogenesis of bone cells under microfluidic shear stress by holographic microscopy and automatic aberration compensation with deep learning

期刊: LAB ON A CHIP, 2021; 21 (7)

We present sensing time-lapse morphogenesis of living bone cells under micro-fluidic shear stress (FSS) by digital holographic (DH) microscopy. To rem......

Rapid and precise tumor cell separation using the combination of size-dependent inertial and size-independent magnetic methods

期刊: LAB ON A CHIP, 2021; 21 (7)

Circulating tumor cells (CTCs) play a significant role in cancer diagnosis and treatment monitoring. One of the major challenges in isolating and dete......

Directing osteoblastic cell migration on arrays of nanopillars and nanoholes with different aspect ratios

期刊: LAB ON A CHIP, 2021; 21 (11)

To realize highly directional guidance for cell migration, both micro- and nano-scale topographies were studied to better understand and mimic the com......

Thermo-responsive fluorinated surfactant for on-demand demulsification of microfluidic droplets

期刊: LAB ON A CHIP, 2021; 21 (18)

Droplet microfluidics has recently emerged as a powerful platform for a variety of biomedical applications including microreactors, bioactive compound......

Auto-Panning: a highly integrated and automated biopanning platform for peptide screening

期刊: LAB ON A CHIP, 2021; 21 (14)

Biopanning, a common affinity selection approach in phage display, has evolved numerous ligands for diagnosis, imaging, delivery, and therapy applicat......

A robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology dagger

期刊: LAB ON A CHIP, 2021; 21 (10)

Two-dimensional digital microfluidic platforms, on which droplets are actuated by electrowetting on dielectrics, have merits such as dynamic reconfigu......

Postoperative evaluation of tumours based on label-free acoustic separation of circulating tumour cells by microstreaming

期刊: LAB ON A CHIP, 2021; 21 (14)

Metastatic tumour recurrence caused by circulating tumour cells (CTCs) after surgery is responsible for more than 90% of tumour-related deaths. A post......

Rotational scan digital LAMP for accurate quantitation of nucleic acids

期刊: LAB ON A CHIP, 2021; 21 (11)

Digital quantitation of nucleic acids is precise and sensitive because of its molecular-level resolution. However, only several quantitation formats a......

A reusable single-cell patterning strategy based on an ultrathin metal microstencil

期刊: LAB ON A CHIP, 2021; 21 (8)

The ability to arrange distinct cells in specific, predefined patterns at single-cell resolution can have broad applications in cell-based assays and ......

Simple and fast isolation of circulating exosomes with a chitosan modified shuttle flow microchip for breast cancer diagnosis

期刊: LAB ON A CHIP, 2021; 21 (9)

Tumor-derived exosomes have been recognized as promising biomarkers for early-stage cancer diagnosis, tumor prognosis monitoring and individual medica......

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