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Meta-Analysis of the Pharmacogenetics of ARMS2 A69S Polymorphism and the Response to Advanced Age-Related Macular Degeneration

期刊: OPHTHALMIC RESEARCH, 2021; 64 (2)

Age-related macular degeneration (AMD) causes irreversible vision loss, and targeted anti-vascular endothelial growth factor (VEGF) therapy is now the......

Growth Rate of Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Meta-Analysis of Natural History Studies and Implications for Designing Future Trials

期刊: OPHTHALMIC RESEARCH, 2021; 64 (2)

Introduction: There is no effective treatment for geographic atrophy (GA). To help design future GA treatment trials, we conducted a meta-analysis for......

A Multicenter Study of the Prevalence of Dry Eye Disease in Chinese Refractive Surgery Candidates

期刊: OPHTHALMIC RESEARCH, 2021; 64 (2)

Objective: The aim of this study was to determine the prevalence of preoperative dry eye disease and evaluate tear film function in refractive surgery......

Associations of Ganglion Cell-Inner Plexiform Layer and Optic Nerve Head Parameters with Visual Field Sensitivity in Advanced Glaucoma

期刊: OPHTHALMIC RESEARCH, 2021; 64 (2)

Purpose: To evaluate the associations of optical coherence tomography (OCT)-derived macular ganglion cell-inner plexiform layer thickness (mGCIPLT), c......

A Systematic Review on Cornea Epithelial-Stromal Homeostasis

期刊: OPHTHALMIC RESEARCH, 2021; 64 (2)

Introduction: This review aims to summarise the role of different cells, genes, proteins and lipid in regulating cornea epithelial-stromal homeostasis......

The Role of Gut Microbiome in Autoimmune Uveitis

期刊: OPHTHALMIC RESEARCH, 2021; 64 (2)

The gut microbiome has important physiological functions and plays an indispensable role in the human body. Currently, there are an increasing number ......

Subthreshold Pan-Retinal Photocoagulation Using Endpoint Management Algorithm for Severe Nonproliferative Diabetic Retinopathy: A Paired Controlled Pilot Prospective Study

期刊: OPHTHALMIC RESEARCH, 2021; 64 (4)

Purpose: The aim of this study was to report the efficacy and safety profile of subthreshold pan-retinal photocoagulation (PRP) using endpoint managem......

Flavonoids Sophoranone Promotes Differentiation of C2C12 and Extraocular Muscle Satellite Cells

期刊: OPHTHALMIC RESEARCH, 2021; 64 (2)

Introduction: Paralytic strabismus involves a functional loss of extraocular muscles resulting from muscular or neuronal disorders. Currently, only a ......

Decreased Expression of Sirt1 Contributes to Ocular Behcet's Disease Progression via Th17 and Th22 Response

期刊: OPHTHALMIC RESEARCH, 2021; 64 (4)

Background: Previous studies have indicated that Sirtuin 1 (Sirt1) plays an important role in suppressing inflammatory responses in many diseases. How......

Protective Effect of a Bispecific Fc-Fusion Protein on the Barrier of Human Retinal Pigment Epithelial Cells

期刊: OPHTHALMIC RESEARCH, 2021; 64 (4)

Introduction: The aim of the study was to evaluate the protective effects of IBI302, a bispecific Fc-fusion protein that theoretically can bind vascul......

The Role of Serum Inflammation-Based Factors in Anti-Vascular Endothelial Growth Factor Treatment for Macular Edema Secondary to Retinal Vein Occlusion and Its Subtypes

期刊: OPHTHALMIC RESEARCH, 2021; 64 (2)

Objective: The aim of this work was to evaluate the association between pretreatment inflammation-based factors and outcomes in patients with macular ......

TRPML1 Inhibited Photoreceptor Apoptosis and Protected the Retina by Activation of Autophagy in Experimental Retinal Detachment

期刊: OPHTHALMIC RESEARCH, 2021; 64 (4)

Objective: In this study, we used a rat model of retinal detachment (RD) to investigate the effects of transient receptor potential mucolipin 1 (TRPML......

A Comparison of Subconjunctival Wound Healing between Different Methods of Dissecting Subconjunctival Tissues

期刊: OPHTHALMIC RESEARCH, 2021; 64 (1)

Objective: To compare different methods for dissecting subconjunctival tissues by developing subconjunctival wound healing models. Methods: New Zealan......

Accuracy of Constant C for Ray Tracing: Assisted Intraocular Lens Power Calculation in Normal Ocular Axial Eyes

期刊: OPHTHALMIC RESEARCH, 2021; 64 (1)

Objective: To evaluate the effect of constant C for ray tracing-assisted intraocular lens (IOL) power calculation in patients with different refractiv......

Higher TGF-beta 1, TGF-beta 2, MMP-2, and TIMP-1 Levels in the Aqueous Humor of Patients with Acute Primary Angle Closure

期刊: OPHTHALMIC RESEARCH, 2021; 64 (1)

Purpose: To assess the quantitative differences in the levels of members of the transforming growth factor (TGF-beta), matrix metalloproteinase (MMP),......

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