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Panax notoginseng Saponins Attenuate Neuroinflammation through TXNIP-Mediated NLRP3 Inflammasome Activation in Aging Rats

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (10)

Introduction: Microglia-mediated inflammatory responses play a crucial role in aging-related neurodegenerative diseases. The TXNIP/NLRP3 pathway is a ......

Luteolin Stimulates Proliferation and Inhibits Late Differentiation of Primary Rat Calvarial Osteoblast Induced by High-dose Dexamethasone via Sema3A/NRP1/Pleixin A1

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (11)

Background: Although Semaphorin 3A (Sema3A)/ Neuropilin-1(NRP1)/Plexin A1 is one of the important targets in bone metabolism, few studies are performe......

Effects of Probiotic Preparations on Inflammatory Cytokines in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (10)

Objective: To summarize and assess the effects of probiotic preparations on inflammatory cytokine levels in patients with Chronic Kidney Disease (CKD)......

GR beta Regulates Glucocorticoid Resistance in Sudden Sensorineural Hear-ing Loss

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (9)

Background: In recent years, the incidence of sudden deafness has gradually increased, with a very limited understanding of its etiology and pathogene......

Applications and Functions of gamma-Poly-Glutamic Acid and its Derivatives in Medicine

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (11)

Background: gamma-Poly-Glutamic Acid (gamma-PGA) is a naturally occurring homo-polyamide produced by various strains of Bacillus. It is made from repe......

Advances in the Occurrence of Pyroptosis: A Novel Role in Atherosclerosis

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (12)

Pyroptosis is a new type of pro-inflammatory programmed cell death identified over the last few years and has since attracted researchers' attention. ......

Recent Advances in Molecular Marker-Assisted Breeding for Quality Improvement of Traditional Chinese Medicine

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (6)

Background: The quality of traditional Chinese medicine (TCM), reflected by its bioactive compounds and associated contents, is directly linked to its......

Restoration of Intestinal Mucosa in Euphorbia kansui-treated Severe Acute Pancreatitis Rats based on HMGB1/MFG-E8 Expression

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (12)

Background: The pathogenesis of Severe Acute Pancreatitis (SAP) is mediated substantially by dysfunctions in the intestinal barrier. Euphorbia kansui ......

The Anti-inflammatory Effects of Lignan Glycosides from Cistanche tubu- losa stems on LPS/IFN-gamma-induced RAW264.7 Macrophage Cells via PI3K/ AKT Pathway

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (10)

Background: Cistanche tubulosa is a tonic in traditional Chinese medicines and has a broad spectrum of biological activity, including anti-inflammator......

Transcriptional Factor-Mediated Regulation of Active Component Biosynthesis in Medicinal Plants

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (6)

Background: Plants produce thousands of chemically diverse secondary metabolites, many of which have valuable pharmaceutical properties. There is much......

Therapeutic Potential of Non-Coding RNAs and TLR Signalling Pathways in Rheumatoid Arthritis

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (11)

Background: Rheumatoid Arthritis (RA) is a common connective tissue disease, characteristic of chronic and invasive synovitis in single or multiple jo......

Biogenesis and Application of Nickel Nanoparticles: A Review

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (6)

Background: Biogenic synthesis of nanoparticles (NPs) is attractive due to their ecological benefits and cheap, rapid, and sustainable nature. Among t......

Mesenchymal Stromal Cell-derived Exosomes Attenuate Experimental Pulmonary Arterial Hypertension

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (12)

Background: Pulmonary arterial Hypertension (PH) is a chronic disease that ultimately progresses to right ventricular failure and death. Until now, th......

Paeoniflorin Affects Hepatocellular Carcinoma Progression by Inhibiting Wnt/beta-Catenin Pathway through Downregulation of 5-HT1D

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (9)

Background: Hepatocellular Carcinoma (HCC) is a primary liver cancer with high mortality. Paeoniflorin is a pinane monoterpene picroside with anti-tum......

Mir-320b Inhibits Pancreatic Cancer Cell Proliferation by Targeting FOXM1

期刊: CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021; 22 (8)

Background: Pancreatic ductal adenocarcinoma (PDAC) is the most common and deadly cancer. Surgical resection is the only possible cure for pancreatic ......

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