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Clinical significance of serum autoantibodies in patients with sarcoidosis

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023; 45 (4)

BackgroundThe association between sarcoidosis and autoimmunity has been reported for years. However, the significance of autoantibodies in the pathoph......

Protective effects of Tripterygium glycoside on IL-1β-induced inflammation and apoptosis of rat chondrocytes via microRNA-216a-5p/TLR4/NF-κB axis

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023; 45 (1)

Background: This study is designed to fill the research gap concerning the efficacy of Tripterygium glycoside (TG) on Interleukin-1 beta (IL-1 beta)-i......

Fraxetin suppresses the proliferation, migration, and invasion of ovarian cancer cells by inhibiting the TLR4/STAT3 signaling pathway

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023; 45 (3)

Background Little therapeutic effect can be exerted on malignant ovarian cancer at the terminal period. Traditional Chinese medicine (TCM) has been a ......

miR-155-5p/FOXO3a promotes pulmonary fibrosis in rats by mediating NLRP3 inflammasome activation

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023; 45 (3)

Objective: Pulmonary fibrosis (PF) is regarded as progressive lung disease. miR-155-5p depletion exerts anti-fibrotic effects in silicotic mice. This ......

Imperatorin inhibits LPS-induced bone marrow-derived macrophages activation by decreased NF-κB p65 phosphorylation

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023; 45 (5)

Background Imperatorin (IMP) is a secondary metabolite of plants and is the most abundant in Angelica dahurica. Previous studies showed that IMP exhib......

Knockdown of A20 attenuates microglial susceptibility to OGD/R-induced ferroptosis and upregulates inflammatory responses

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023; 45 (5)

The A20 protein is considered to have a potent anti-inflammatory effect, but its mechanism of action in the regulation of ferroptosis and inflammation......

Sulforaphane suppresses skin squamous cell carcinoma cells proliferation through miR-199a-5p/Sirt1/CD44ICD signaling pathway

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023; 45 (1)

Background The present study aimed to explore the impact of sulforaphane on the growth of sSCC cells, and the activation of miR-199a-5p/Sirt1 and CD44......

Molecular mechanisms mediate roflumilast protective effect against isoprenaline-induced myocardial injury

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023; 45 (6)

Background: Myocardial necrosis is one of the most common cardiac and pathological diseases. Unfortunately, using the available medical treatment is n......

Leukoreduced PRP enhanced proliferation and ECM production yet inhibited senescence, inflammation, and multi-differentiation potential of AFSCs by downregulating HMGB1

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023; 45 (6)

Background: This study assessed the role and potential mechanism of platelet-rich plasma (PRP) in the progression of intervertebral disk degeneration ......

Hepatoprotective actions of melatonin by mainly modulating oxidative status and apoptosis rate in lipopolysaccharide-induced liver damage

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023; ()

AimOne of the serious complications of sepsis is liver damage and liver failure. This study aimed to evaluate the protective and therapeutic potential......

Scutellarin alleviates lipopolysaccharide-provoked septic nephrotoxicity via attenuation of inflammatory and oxidative events and mitochondrial dysfunction

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023; 45 (3)

Background Sepsis-associated acute kidney injury (AKI) is highlighted by high incidence of mortality and morbidity. Scutellarin is a flavone extracted......

Isoliquiritin modulates ferroptosis via NF-κB signaling inhibition and alleviates doxorubicin resistance in breast cancer

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023; 45 (4)

Context: Breast cancer (BC) is the most prevalent diagnosed tumor and the major reason for tumor-related death in females around the world. Isoliquiri......

KLF5-mediated aquaporin 3 activated autophagy to facilitate cisplatin resistance of gastric cancer

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023; 45 (2)

Background Resistance to chemotherapeutic drugs limits the control of gastric cancer (GC) development. The study intended to probe into the mechanism ......

Pre-clinical investigation of protective effect of nutraceutical D-glucosamine on TNBS-induced colitis

期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2023; 45 (2)

Objective: The level of precursors involved in the biosynthesis of glycosaminoglycan (GAG), glucosamine synthase, and N-acetyl glucosamine (NAG), are ......

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