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Regulation of trehalose metabolism in insects: from genes to the metabolite window

期刊: GLYCOBIOLOGY, 2023; 33 (4)

Trehalose is a major circulatory sugar in the haemolymph of insects. It provides instant energy and protection against stress. Trehalose metabolism is......

Role of glycosylation in breast cancer progression and metastasis: implications for miRNA, EMT and multidrug resistance

期刊: GLYCOBIOLOGY, 2023; 33 (7)

Breast cancer (BC) is one of the leading causes of death in women, globally. A variety of biological processes results in metastasis, a poorly underst......

Single-mutations at the galactose-binding site of enzymes Galk, GalU, and LgtC enable the efficient synthesis of UDP-6-azido-6-deoxy-d-galactose and azido-functionalized Gb3 analogs

期刊: GLYCOBIOLOGY, 2023; 33 (8)

Lysosomal accumulation of the glycosphingolipid globotriaosylceramide Gb3 is linked to the deficient activity of the alpha-galactosidase A in the Ande......

Lewis a-b- histo-blood group antigen phenotype is predictive of severe COVID-19 in the black South African population group

期刊: GLYCOBIOLOGY, 2023; ()

Several risk factors have been associated with SARS-CoV-2 infections and severity of COVID-19 disease it causes. This study investigated whether varia......

Characterization of novel antibodies that recognize sialylated keratan sulfate and lacto-N-fucopentaose I on human induced pluripotent cells: comparison with existing antibodies

期刊: GLYCOBIOLOGY, 2023; 33 (2)

This report describes the isolation and characterization of two new antibodies, R-6C (IgM) and R-13E (IgM), which were generated in C57BL/6 mice (Mus ......

A combinatorial DNA assembly approach to biosynthesis of N-linked glycans in E. coli

期刊: GLYCOBIOLOGY, 2023; 33 (2)

Glycoengineering of recombinant glycans and glycoconjugates is a rapidly evolving field. However, the production and exploitation of glycans has lagge......

Differential impact of glycation on apolipoprotein A-I of high-density lipoprotein: a review

期刊: GLYCOBIOLOGY, 2023; 33 (6)

Hyperglycemia is a poorly controlled diabetic condition, affects about 70% of people all round the world. In the year 2015, about 41.5 crore people we......

Direct antitumoral effects of sulfated fucans isolated from echinoderms: a possible role of neuropilin-1/β1 integrin endocytosis and focal adhesion kinase degradation

期刊: GLYCOBIOLOGY, 2023; 33 (9)

Hypercoagulability, a major complication of metastatic cancers, has usually been treated with heparins from natural sources, or with their synthetic d......

Transport of N-acetylchitooligosaccharides and fluorescent N-acetylchitooligosaccharide analogs into rat liver lysosomes

期刊: GLYCOBIOLOGY, 2023; ()

Free polymannose-type oligosaccharides (fOS) are processed by cytosolic enzymes to generate Man5GlcNAc which is transferred to lysosomes and degraded.......

Identification and characterization of a deaminoneuraminic acid (Kdn)-specific aldolase from Sphingobacterium species

期刊: GLYCOBIOLOGY, 2023; 33 (1)

Sialic acid (Sia) is a group of acidic sugars with a 9-carbon backbone, and classified into 3 species based on the substituent group at C5 position: N......

Siglec cis-ligands and their roles in the immune system

期刊: GLYCOBIOLOGY, 2023; 33 (7)

Sialic acid-binding immunoglobulin-like lectins are a family of membrane molecules primarily expressed in immune cells. Most of them are inhibitory re......

Expression of low-sulfated keratan sulfate in non-mucinous ovarian carcinoma

期刊: GLYCOBIOLOGY, 2023; ()

Keratan sulfate glycosaminoglycan is composed of repeating N-acetyllactosamine (LacNAc) disaccharide units consisting of galactose (Gal) and N-acetylg......

CRISPR-screen identifies ZIP9 and dysregulated Zn2+ homeostasis as a cause of cancer-associated changes in glycosylation

期刊: GLYCOBIOLOGY, 2023; 33 (9)

Introduction: In epithelial cancers, truncated O-glycans, such as the Thomson-nouveau antigen (Tn) and its sialylated form (STn), are upregulated on t......

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