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Interaction of quercetin and its derivatives with Ca2+-ATPase from sarcoplasmic reticulum: Kinetic and molecular modeling studies

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023; 42 (5)

Sarcoplasmic reticulum Ca2+-ATPases (SERCAs) regulate cellular calcium homeostasis and are targeted for age-related diseases. Among 14 SERCA mRNA spli......

Effects of curcumin and melatonin treatment in the cerebral cortex of adult rats

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023; 42 (1)

The study investigated the effect of exogenous melatonin and (or) curcumin treatment on the cerebral cortex of adult rats. In this context, malondiald......

Molecular mechanism of the protective effect of adenosine triphosphate against paracetamol-induced liver toxicity in rats

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023; 42 (2)

Toxic doses of paracetamol are also known to be close to therapeutic doses. This study aimed to biochemically investigate the protective effect of ATP......

Biomedical research brings mTBI biomarkers a step closer to the bedside-implementation in clinical practice

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023; 42 (4)

Research in the field of TBI (traumatic brain injury) has long been focused on severe brain injury, while the number of mild injuries far overweigh se......

Immunobiochemical profile of clear cell renal cell carcinoma (ccRCC): A preliminary study

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023; 42 (5)

Clear cell renal cell carcinoma (ccRCC) is the most common variant of RCC. It is an aggressive disease with an unfavorable prognosis. The rich immune ......

Testicular cytoprotective effect of glucagon like peptide-1 in diabetic rats involves inhibition of apoptosis, endoplasmic reticulum stress and activation of autophagy

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023; 42 (2)

This study aimed to explore the possible cytoprotective effects of exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in the testicles of ......

Oxidative stress parameters and their relation to motor subtype of Parkinson's disease and levodopa treatment status

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023; 42 (1)

Parkinson's disease (PD) is an oxidative stress-linked neurodegenerative disorder, with the highest prevalence among seniors. The objective of this st......

Ivabradine curbs isoproterenol-induced kidney fibrosis

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023; 42 (2)

This study investigated whether chronic isoproterenol administration could induce kidney alterations and whether ivabradine, a heart rate (HR)-reducin......

Cholecalciferol affects cardiac proteins regulating malonyl-CoA availability and intracellular calcium level

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023; 42 (3)

Cholecalciferol improves insulin signaling and glucose metabolism in the heart and reduces circulating non-esterified fatty acids. Cholecalciferol eff......

The effects of the pulsed magnetic field on sepsis-induced liver tissue injury in rats

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023; 42 (6)

Sepsis is the host's response to infection and can lead to severe and life-threatening cases. We aimed to investigate the effects of pulsed magnetic f......

Stress, depression, and hippocampus: from biochemistry to electrophysiology

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023; 42 (2)

Major depressive disorder is a very common serious mental illness with increasing prevalence in the population. Its pathology includes biochemical, mo......

High-fructose intake-induced dyslipidemia and oxidative stress accompanied by hippocampal dysfunctions in hypertensive but not hypertriacylglycerolemic rats

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023; 42 (1)

A high-fructose intake is metabolically analogous to a high-fat diet. The impact of highfructose intake was investigated in spontaneously hypertensive......

Anionic lipids modulate little the reorganization effect of amyloid-beta peptides on membranes

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023; 42 (1)

Amyloid-ss peptide interactions with model lipid membranes have been studied by means of small angle neutron scattering and molecular dynamics simulat......

Effects of the acute administration of delta-opioid receptor ligands on the excitability of rat hippocampal glutamate and brainstem monoamine neurons in vivo

期刊: GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023; 42 (3)

It was previously reported that the delta opioid receptor (DOR) agonist SNC80 and antagonist naltrindole modulate the excitability of hippocampal glut......

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