期刊： DRUG DEVELOPMENT RESEARCH, 2023; 84 (8)
New thiazole, thiazolopyrimidine, and thiazolotriazine derivatives 3-12 and 14a-f were synthesized. The newly synthesized analogs were tested for in v......
期刊： DRUG DEVELOPMENT RESEARCH, 2023; 84 (7)
FAM64A is a mitogen-induced regulator of the metaphase and anaphase transition. Here, we found that FAM64A messenger RNA (mRNA) and protein expression......
期刊： DRUG DEVELOPMENT RESEARCH, 2023; ()
In a search for novel nonsugar alpha-glucosidase inhibitors for diabetes treatment, a series of N-(phenylsulfonyl)thiazole-2-carboxamide derivatives w......
期刊： DRUG DEVELOPMENT RESEARCH, 2023; ()
Imidazopyridine scaffold holds significant pharmacological importance in the treatment of cancer. An in-house synthesized imidazopyridine-based molecu......
期刊： DRUG DEVELOPMENT RESEARCH, 2023; ()
Osteosarcoma (OS) is a primary malignant bone tumor characterized by frequent metastasis, rapid disease progression, and a high rate of mortality. Tre......
期刊： DRUG DEVELOPMENT RESEARCH, 2023; 84 (6)
This study was conducted to determine the safety of topical naltrexone treatment in Gottingen swine. Efficacy of topical naltrexone was performed prev......
期刊： DRUG DEVELOPMENT RESEARCH, 2023; 84 (5)
A series of 12 S-substituted tetrahydrobenzothienopyrimidines were designed and synthesized based on the donepezil scaffold. All the newly synthesized......
期刊： DRUG DEVELOPMENT RESEARCH, 2023; 84 (5)
This study aims to assess studies on circular RNAs (circRNAs) in the chemoresistance of triple-negative breast cancer (TNBC) and provide relevant refe......
期刊： DRUG DEVELOPMENT RESEARCH, 2023; 84 (6)
Facing the sudden outbreak of coronavirus disease 2019 (COVID-19), it is extremely urgent to develop effective antiviral drugs against severe acute re......
期刊： DRUG DEVELOPMENT RESEARCH, 2023; 84 (3)
Kaempferol (Kae) is a natural flavonoid that has multiple biological activities, such as anti-inflammatory and antitumor activities. However, few stud......
期刊： DRUG DEVELOPMENT RESEARCH, 2023; 84 (5)
Background: Nonsmall cell lung cancer (NSCLC) is the main type of lung cancer, accounting for approximately 85%. Berberine (BBR), a commonly used trad......
期刊： DRUG DEVELOPMENT RESEARCH, 2023; 84 (5)
Inhibiting alpha-glucosidase is a reliable method for reducing blood sugar levels in diabetic individuals. Several novel chromen-linked hydrazine carb......
期刊： DRUG DEVELOPMENT RESEARCH, 2023; 84 (7)
Phthalimide, a pharmacophore exhibiting diverse biological activities, holds a prominent position in medicinal chemistry. In recent decades, numerous ......
期刊： DRUG DEVELOPMENT RESEARCH, 2023; ()
Estrogen receptor is an important target in breast cancer. Serotonin receptors (5-HT2A and 5-HT2C, in particular) were investigated for a potential ro......
期刊： DRUG DEVELOPMENT RESEARCH, 2023; 84 (2)
Recent years have witnessed the rapid development of targeted protein degradation (TPD), especially proteolysis targeting chimeras. These degraders ha......
