期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 78 ()
The naturally-occurring di-catechol lignan nordihydroguaiaretic acid (NDGA) and an analog without methyl groups on the butyl linker both undergo intra......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 82 ()
Peroxisome proliferator-activated receptor d (PPARd) is considered to be a target for treating metabolic syndrome, whereas there is no PPARd agonist i......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 93 ()
Herein, we report the development of a new series of histone deacetylase inhibitors (HDACi) containing a 2-substituted 1,5-benzothiazepine scaffold. F......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 93 ()
The epigenetic regulation of the protein bromodomain-containing protein 4 (BRD4) has emerged as a compelling target for cancer treatment. In this stud......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 93 ()
Heparanase-1 (HPSE1) is an endo-& beta;-D-glucuronidase that is the only mammalian enzyme known to cleave heparan sulfate (HS) of heparan sulfate ......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 95 ()
Proteolysis-targeting chimera (PROTAC) technology is a disruptive innovation in the drug development community, and over 20 PROTAC molecules are curre......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 78 ()
To discover small molecules as acid alpha-glucosidase (GAA) stabilizers for potential benefits of the exogenous enzyme treatment toward Pompe disease ......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 93 ()
Phosphatidylinositol transfer proteins (PITPs) are ubiquitous in eukaryotes and are involved in the regulation of phospholipid metabolism, membrane tr......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 78 ()
This study was aimed at developing a novel platform for tetravalent conjugation of 4-arm polyethylene glycol (PEG) with an antisense oligonucleotide (......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 92 ()
The hybrid heterocyclic molecules are perspective materials in the development of anticancer drugs. Here, the pyrrolidinedione-thiazolidinone hybrid m......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 95 ()
Chronic Inflammation is associated with various types of diseases that involves pro-inflammatory cytokines like IL-6 and TNF-alpha. High costs and ser......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 90 ()
To develop matrix metalloproteinase inhibitors (MMPIs) for both therapy and medicinal imaging by fluorescence-based techniques or positron-emission to......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 92 ()
Gonorrhea has become a serious problem because the number of infected people is increasing and the multi-drug resistance of the causative bacteria, Ne......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 94 ()
Galectins, a family of endogenous glycan-binding proteins, play crucial roles in a broad range of physiological and pathological processes. Galectin-1......
期刊： BIOORGANIC & MEDICINAL CHEMISTRY, 2023; 95 ()
Staphylococcus aureus is a highly adaptable opportunistic pathogen that can form biofilms and generate persister cells, leading to life-threatening in......
