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Identification of a leucine-zipper motif in pUL51 essential for HCMV replication and potential target for antiviral development

期刊: ANTIVIRAL RESEARCH, 2023; 217 ()

Human cytomegalovirus (HCMV) can cause serious diseases in immunocompromised patients. Use of current antivirals is limited by their adverse effects a......

Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5

期刊: ANTIVIRAL RESEARCH, 2023; 219 ()

Yellow fever virus (YFV) infection is a major public concern that threatens a large population in South America and Africa. No specific antiviral drug......

SRPKIN-1 as an inhibitor against hepatitis B virus blocking the viral particle formation and the early step of the viral infection

期刊: ANTIVIRAL RESEARCH, 2023; 220 ()

New antiviral agents are needed for the treatment of hepatitis B virus (HBV) infection because currently available drugs do not completely eradicate c......

Omicsynin B4 potently blocks coronavirus infection by inhibiting host proteases cathepsin L and TMPRSS2

期刊: ANTIVIRAL RESEARCH, 2023; 214 ()

The emergence of SARS-CoV-2 variants represents a major threat to public health and requires identification of novel therapeutic agents to address the......

Avasimibe can cooperate with a DC-targeting and integration-deficient lentivector to induce stronger HBV specific T cytotoxic response by regulating cholesterol metabolism

期刊: ANTIVIRAL RESEARCH, 2023; 216 ()

We have reported a lentivector which could effectively induce HBV-specific cytotoxic T lymphocytes (CTLs). Avasimibe is an inhibitor of acetyl-CoA ace......

Seasonal coronavirus infections trigger NLRP3 inflammasome activation in macrophages but is therapeutically targetable

期刊: ANTIVIRAL RESEARCH, 2023; 216 ()

Seasonal coronaviruses widely circulate in the global population, and severe complications can occur in specific vulnerable populations. Little is kno......

An intronic genetic variant of ZHX2 predicts response to pegylated interferon α therapy in HBeAg-positive chronic hepatitis B patients

期刊: ANTIVIRAL RESEARCH, 2023; 220 ()

ZHX2 plays a crucial role in host immunity and modulates hepatitis B virus (HBV) replication. However, its correlation with immunomodulator-related tr......

Expanding the anti-flaviviral arsenal: Discovery of a baicalein-derived Compound with potent activity against DENV and ZIKV.

期刊: ANTIVIRAL RESEARCH, 2023; 220 ()

With approximately 3.8 billion people at risk of infection in tropical and sub-tropical regions, Dengue ranks among the top ten threats worldwide. Des......

Newcastle Disease Virus (NDV)-based vaccine candidate against SARS-CoV-2 Omicron by intranasal immunization

期刊: ANTIVIRAL RESEARCH, 2023; 220 ()

Despite global vaccination efforts, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and spread globally. Currently, t......

A bivalent form of a RBD-specific synthetic antibody effectively neutralizes SARS-CoV-2 variants

期刊: ANTIVIRAL RESEARCH, 2023; 220 ()

Coronavirus Disease 2019 (COVID-19) pandemic is severely impacting the world, and tremendous efforts have been made to deal with it. Despite many adva......

Kill or corrupt: Mechanisms of action and drug-resistance of nucleotide analogues against SARS-CoV-2

期刊: ANTIVIRAL RESEARCH, 2023; 210 ()

Nucleoside/tide analogues (NAs) have long been used in the fight against viral diseases, and now present a promising option for the treatment of COVID......

Novel bispecific human antibody platform specifically targeting a fully open spike conformation potently neutralizes multiple SARS-CoV-2 variants

期刊: ANTIVIRAL RESEARCH, 2023; 212 ()

Rapid emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has prompted an urgent need for the development of bro......

miR-548c-3p targets TRIM22 to attenuate the Peg-IFN-? therapeutic efficacy in HBeAg-positive patients with chronic hepatitis B

期刊: ANTIVIRAL RESEARCH, 2023; 213 ()

Chronic hepatitis B (CHB) patients treated with interferon shows encouraging results. However, its clinical ef-ficacy is limited by significant indivi......

Lung transcriptomics of K18-hACE2 mice highlights mechanisms and genes involved in the MVA-S vaccine-mediated immune response and protection against SARS-CoV-2 infection

期刊: ANTIVIRAL RESEARCH, 2023; 220 ()

Unravelling the molecular mechanism of COVID-19 vaccines through transcriptomic pathways involved in the host response to SARS-CoV-2 infection is key ......

A phenothiazine urea derivative broadly inhibits coronavirus replication via viral protease inhibition

期刊: ANTIVIRAL RESEARCH, 2023; 220 ()

Coronavirus (CoV) replication requires efficient cleavage of viral polyproteins into an array of non-structural proteins involved in viral replication......

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