The Journal of Neuroscience Methods publishes research papers and a limited number of broad and critical reviews dealing with new methods or significant developments of recognised methods, used to investigate the organisation and fine structure, biochemistry, molecular biology, histo- and cytochemistry, physiology, biophysics and pharmacology of receptors, neurones, synapses, and glial cells, in the nervous system of man, vertebrates and invertebrates, or applicable to the clinical and behavioural sciences, tissue culture, neurocommunications, biocybernetics or computer software. Although articles should be written in sufficient detail to allow others to verify these methods, they should also be intelligible to a broad scientific audience. In addition, the journal will publish letters in a camera-ready format containing comments or discussion of methodology described in this journal, or any other journal devoted to the neurosciences. Articles should be submitted to the Editor-in-Chief. Submission of a paper to the Journal of Neuroscience Methods implies that it is not being submitted for publication elsewhere.