IEEE Computer Society Transactions are scholarly archival journals designed to inform readers on the state of the art in a number of specialized fields related to computers and computing. Each Transactions is headed by a volunteer editor-in-chief whose task is to solicit and/or accept manuscripts, distribute them to recognized experts for peer review, schedule them for publication, and have the resulting product archived for posterity. The IEEE/ACM Transactions on Computational Biology and Bioinformatics is a new quarterly that will publish archival research results related to the algorithmic, mathematical, statistical, and computational methods that are central in bioinformatics and computational biology; the development and testing of effective computer programs in bioinformatics; the development and optimization of biological databases; and important biological results that are obtained from the use of these methods, programs, and databases.