Environmental physiology assumes great significance in our national context in view of the diverse climatic conditions prevailing in different regions. Troops have to operate in diverse environmental conditions guarding the frontiers. Hence, the research in this area has been focused on the usage of field studies in the natural environments or simulated environments in the laboratory. Besides, the application of the simulation chambers in the research on the physiological effects of diverse environments, these studies may have applications in the control and management of certain clinical disorders. Some simulation chambers and specialised set-ups have been designed and developed at the Defence Institute of Physiology and Allied Sciences to carry out simulation studies. This paper describes these developments and the potentials of these biomedical applications of simulated environments.