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JACC:CardioOncology Instructions for Authors

JACC: CardioOncology Author Instructions

Updated March 1, 2024. Red font indicates the latest edits and changes.

Introduction

Article Types
General Manuscript Organization
General Manuscript Content
Editorial Policies
JACC Journals Publication Integrity Guidelines

Contacting Us

Introduction

JACC: CardioOncology

JACC:CardioOncology

We request that all manuscripts be submitted online at https://www.jaccsubmit-cardiooncology.org. Manuscript submissions should conform to the guidelines set forth in the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publication" which are available at http://www.icmje.org. For English language editing services, Elsevier can direct authors upon request to a service that can assist with this prior to submission. Please visit https://webshop.elsevier.com/language-editing-services/language-editing.

Open Access

http://www.elsevier.com/openaccesslicenses)

Creative Commons Attribution-Noncommercial-NoDerivs (CC BY-NC-ND). For non-commercial purposes, this license allows others to distribute and copy the article and include in a collective work (such as an anthology), as long as they credit the author(s) and provided they do not alter or modify the article.

If you need to comply with your funding body policy, you can apply for a CC-BY license after your manuscript is accepted for publication.

To provide open access, this journal has an open access fee (also known as an article publishing charge, aka APC) which needs to be paid by the authors, or, for example, on their behalf by their research funding organization or institution. The open access fee for full Original Investigations is $3,866, and $1,600 for Research Letters with a 10% discount for American College of Cardiology members. We also offer a discount of 50% if the first, corresponding, or senior author is from a developing country. (Note: Discounts exclude taxes and are not cumulative.) Other manuscript submissions will not be subject to an APC charge. Learn more about Elsevier's pricing policy: http://www.elsevier.com/openaccesspricing

Funding Body Agreements and Policies

http://www.elsevier.com

After acceptance, open access papers will be published under a noncommercial license. For authors requiring a commercial CC BY license, you can apply after your manuscript is accepted for publication.

Authorship/Cover Letter

Each author must have contributed significantly to the submitted work. The contribution of each author should be delineated in the cover letter. If authorship is attributed to a group (either solely or in addition to 1 or more individual authors), all members of the group must meet the full criteria and requirements for authorship. To save space, if group members have been previously published, the article should be referenced rather than reprinting the list of names. The Editors consider authorship to include all of the following:

Conception and design or analysis and interpretation of data, or both;
Drafting of the manuscript or revising it critically for important intellectual content; and
Final approval of the manuscript submitted.

Participation solely in the collection of data does not justify authorship but may be appropriately acknowledged in the Acknowledgment section. Manuscripts must be submitted with a cover letter stating:

The paper is not under consideration elsewhere;
None of the paper's contents have been previously published;
All authors have read and approved the manuscript; and
The full disclosure of any potential conflict of interest (see "Relationship With Industry Policy").

Please note that copyright is now handled by the publisher and no copyright form will be sent to you until the manuscript has been sent to the publisher. Only authors appearing on the final title page will be sent a relationship with industry form. YOU CANNOT ADD AUTHORS AFTER ACCEPTANCE OR ON PROOFS.JACC: CardioOncology publishes the following manuscript types: Original Investigations, State-of-the-Art Reviews, Primers in Cardio-Oncology, Research Letters, Clinical Case Challenges, Viewpoints, and Letters to the Editor. Regardless of manuscript type, each publication should answer the question: "How does this work potentially impact the clinical care of cancer patients?"

Exclusive Submission/Publication Policy

Elsevier will maintain copyright records for the College. Sharing of data from manuscripts that are under review or accepted but not yet published is expressly forbidden, unless permission is received from the JACC Journals Editorial Office. We ask that authors disclose this information during the submission process.

JACC Journals does not consider the posting of manuscripts to a preprint server a prior publication, if they have not undergone peer review and provided that the following conditions are met: 1) when submitting a manuscript to a JACC journal, authors must acknowledge preprint server deposition and provide all associated accession numbers or DOIs; 2) versions of a manuscript that have been altered as a result of our peer review process may not be deposited; 3) the preprint version cannot have been indexed in MEDLINE or PubMed; and 4) upon publication in a JACC journal, authors are responsible for updating the archived preprint with a DOI and link to the published version of the article. Should the paper be accepted and published in a JACC journal, that JACC journal DOI should be considered to be the one representing this published work in all credits, citation, and attribution.

Submission Declaration and Verification

Multiple, redundant, or concurrent publication

https://www.elsevier.com/editors/perk/plagiarism-complaints/plagiarism-detection

Original Investigations

JACC: CardioOncology

http://www.onlinejacc.org/content/74/22/2816

Click here for a template to use in formatting your submission:

https://www.jaccsubmit-cardiooncology.org/html/ORPTemplate.docx

Word count: No more than 5,000 words (text from the introduction to the conclusion, including references and figure legends).
No more than two joint authors in any position.
Abstract: Structured and no more than 250 words with the following headings: Background, Objectives, Methods, Results, Conclusions. The abstract should present essential data in 5 paragraphs. Use complete sentences. All data in the abstract also must appear in the manuscript text or tables.
Results: Report all p-values <0.10 using 3 digits to the right of the decimal and p-values >0.10 are presented using only 2 digits to the right.
Study limitations (required): Please include the limitations of your investigation at the end of the discussion section of your manuscript and designate this section with a header to clearly identify it.
Figure/Table Limit: None
Central Illustration: Required
Clinical Perspectives: Required
Ethical Approval: Required. Please denote that your study received the proper ethical oversight in both your cover letter and the first paragraph of your Methods section. For manuscripts reporting data on human subjects, note institutional review board/ethics committee approval (or formal review and exemption), including the specific name of the board or committee. For studies involving animal experiments, note that the study complied with all institutional and national requirements for the care and use of laboratory animals and, if applicable, received animal care and use committee approval. State the animal-handling protocol in your Methods.

State-of-the-Art Review

jaccco@acc.org

https://www.jaccsubmit-cardiooncology.org/html/SOATemplate.docx

Word count: no more than 10,000 words (text from the introduction to the conclusion, including references and figure legends)
No more than two joint authors in any position
Abstract: Unstructured and no more than 150 words
Figure Limit: None
Table Limit: None
Central Illustration: Required
Clinical Perspectives: Not applicable
Highlights/Main Messages: Required

Please be sure you have obtained or will obtain permission for previously published tables, figures, or any material for which you cannot grant copyright.

Expert Panel

JACC:CardioOncology

JACC:CardioOncologyExpert Panel submissions must be invited by the Editor-in-Chief or proposed to and approved by the Editor-in-Chief prior to submission. Please submit proposals (outline, mock tables and figures, and proposed writing committee) to jaccco@acc.org

Primers in Cardio-Oncology

The Editors will consider both invited and volunteered evidence-based, rigorously developed articles regarding research methodology in both basic and clinical science; evidence-based best clinical practices; cardio-oncology training and career development; health care innovation; or explanation of cardiovascular or oncologic drug therapies (including mechanisms of action and relevance to cardio-oncology).

Short-Form

Click here for a template to use in formatting your submission:https://www.jaccsubmit-cardiooncology.org/html/SFPTemplate.docx

Word count: no more than 2,000 words (text from the introduction to the conclusion, including references and figure legends). Please refrain from using subheadings within the text.
Abstract: Not applicable
Authors: No more than 10; no joint authorship permitted
References: No more than 10
Figures/Tables: 2 single-paneled figures OR 1 simple table and 1 single-paneled figure
Central Illustration: Not applicable
Highlights: Required
Supplemental Material: Not permitted

The "How To" Series is a type of short-form primer, typically invited, designed to offer very practical guidance regarding the diagnosis and management of clinical scenarios based upon available evidence and expert consensus in the absence of detailed evidence. Example clinical cases are necessary, followed by a discussion of the relevant diagnostic, therapeutic, and management issues. Details regarding the management are meant to be succinct, clinically relevant and actionable. Seminal references informing the decision process should be cited. An example of this manuscript type can be found here: https://www.jacc.org/doi/10.1016/j.jaccao.2020.07.010).

Long Form

Authors should detail in their cover letters how their submission differs from existing publications on this topic. Click here for a template to use in formatting your submission: https://www.jaccsubmit-cardiooncology.org/html/LFPTemplate.docx

Word count: no more than 10,000 words (text from the introduction to the conclusion, including references and figure legends)
No more than 2 corresponding authors
Abstract: Unstructured and no more than 150 words
Figure Limit: None
Table Limit: None
Central Illustration: Required
Highlights/Main Messages: Required
Clinical Perspectives: Not applicable

Please be sure you have obtained or will obtain permission for previously published tables, figures, or any material for which you cannot grant copyright.

Research Letters

Articles are discrete, highly significant, innovative or novel findings reported in a shorter format of 1,000 words or less in length. Click here for a template to use in formatting your submission: https://www.jaccsubmit-cardiooncology.org/html/RLTemplate.docx

Word count: No more than 1,000 words (text from the introduction to the conclusion, including references and figure legends). Please refrain from using subheadings within the text.
Abstract: Not applicable
Authors: No more than 10; no joint authorship permitted
References: No more than 5
Figures/Tables: No more than 1 simple figure (in no more than 2 parts) or 1 simple table)
Central Illustration: Not applicable
Supplemental Material: Not permitted
Ethical Approval: Required. Please denote that your study received the proper ethical oversight in both your cover letter and the body of the article. For manuscripts reporting data on human subjects, note institutional review board/ethics committee approval (or formal review and exemption), including the specific name of the board or committee. For studies involving animal experiments, note that the study complied with all institutional and national requirements for the care and use of laboratory animals and, if applicable, received animal care and use committee approval. State the animal-handling protocol in the body of your article.

Viewpoints

Although usually invited, succinct opinion pieces relevant to a specific aspect of cardio-oncology will also be considered for JACC: CardioOncology.They should not exceed 2,000 words and should have an important and direct clinical implication. It is recommended that a query first be sent to jaccco@acc.org before submitting this manuscript. Click here for a template to use in formatting your submission: https://www.jaccsubmit-cardiooncology.org/html/VPTemplate.docx

Word count: No more than 2,000 words (text from the introduction to the conclusion, including references and figure legends). Please refrain from using subheadings within the text.
Abstract: Not applicable
Authors: No more than 10; no joint authorship permitted
References: No more than 10
Figures/Tables: No more than 1 simple figure (in no more than 2 parts) or 1 simple table)
Central Illustration: Not applicable
Clinical Perspectives: Not applicable
Supplemental Material: Not permitted

Clinical Case Challenge

These pieces will succinctly describe a clinical case in cardio-oncology that highlights a specific challenge in medical care. The step-by-step diagnostic and management approaches will be detailed. A clinical, evidence-based perspective on the current available literature to support the approach to care is mandatory and should be included. Click here for a template to use in formatting your submission: https://www.jaccsubmit-cardiooncology.org/html/CCCTemplate.docx

Word count: No more than 2,000 words (text from the introduction to the conclusion, including references and figure legends). Please refrain from using subheadings within the text.
Abstract: Not required
Authors: No more than 10; no joint authorship permitted
References: No more than 10
Figures/Tables: 2 single-paneled figures OR 1 simple table and 1 single-paneled figure
Central Illustration: Not applicable
Clinical Perspectives: Not applicable
Videos or Supplemental Material: Not permitted

Letters to the Editor and Replies

JACC: Cardio:Oncology will publish a limited number of letters that focus on a specific manuscript that has appeared in the journal. Letters must be submitted within 3 months of the issue date of the article. JACC: CardioOncology does not consider letters to the editor on review articles, editorials, or any correspondence, including research letters. Letters should be submitted online at www.jaccsubmit-cardiooncology.org. Click here for a template to use in formatting your submission: https://www.jaccsubmit-cardiooncology.org/html/LERLETemplate.docx

Word count: No more than 500 words, including references and a figure legend, if applicable
References: No more than 5
Figures/Tables: No more than 1 simple figure (in no more than 2 parts) or 1 simple table
Please include the cited article as the first reference
Authors: No more than 5; no joint authorship permitted
Title: Unique title of 15 words or less that does not include the title of the original investigation
Title page: Required

Editorial Comments

The editors invite all Editorial Comments published in the Journal. If you are invited to write an editorial, specific requirements will be sent to you. Please do not submit unsolicited editorials.

General Manuscript Organization

Cover Letter: A short paragraph telling the editors why the authors think their paper merits publication may be included in the cover letter. Potential reviewers may be suggested in the cover letter, as well as reviewers to avoid. However, final reviewer assignment is determined by the editors.

Ethical Approval:Please denote that your study received the proper ethical oversight in both your cover letter and the first paragraph of your Methods section. For manuscripts reporting data on human subjects, note institutional review board/ethics committee approval (or formal review and exemption), including the specific name of the board or committee. For studies involving animal experiments, note that the study complied with all institutional and national requirements for the care and use of laboratory animals and, if applicable, received animal care and use committee approval. State the animal- handling protocol in your Methods.

Rebuttal Letter (Required for all revisions or appeals): This is a point-by-point response to the editors' and reviewers' comments.)
Tracked Changes Manuscript File (Required for all revisions or appeals): Include a tracked changes version of the manuscript with every resubmission/revision.
Manuscript file (see individual manuscript types and Manuscript Content for specific formatting, and you may also email jaccco@acc.org for a template on how to format your submission.)

The entire manuscript (including tables) should be uploaded as a Microsoft Word document, with 1-inch margins and 12-point Times New Roman font. The title and abstract pages, including keywords and abbreviations, should be single-spaced. All text from the introduction to the end (including tables) should be double-spaced. Page numbering should start with the title page.

Page 1: Title page. See also Manuscript Content, below.
Page 2: Abstract, Key Words, Abbreviations list
Text
Perspectives or Highlights (if applicable)
References
Figure legends, listing both a title and caption for each figure, including the Central Illustration (if applicable). Do not include the caption in the Figure
Tables, each on a separate page
Figures

Supplemental material (if applicable). Please upload all supplemental material, with the exception of videos, as one separately uploaded Word document, labeled Supplemental Appendix. This should include all supplemental text, tables and figures, figure legends, etc.

General Manuscript Content

The order in which these items appear should also be the order in which they appear in your submission.

Title Page

Title (no more than 15 words) and brief title of no more than 45 characters
Authors' names (including full first name, middle initial, last name and degrees--MD, PhD, etc)
Total word count
Departments and institutions with which the authors are affiliated. Indicate the specific affiliations if the work is generated from more than one institution (use superscript letters a, b, c, d, and so on). List only the departments and institutions for co-authors.
Funding: Information on grants, contracts, and other forms of financial support. List the cities and states of all foundations, funds, and institutions involved in the work.
Disclosures: State each author's disclosures (or lack thereof). This must include the full disclosure of any relationship with industry. (See Relationship with Industry section.) If there are no relationships with industry, this should be stated.
Corresponding author contact information: Under the heading, "Address for correspondence," provide the full name and complete postal address of the author to whom communications should be sent. Also provide telephone and fax numbers, an e-mail address, and a Twitter handle, if available. Please also provide a short tweet summarizing your paper to your title page. The tweet should be approximately 280 characters, including spaces. Please include up to three hashtags with your tweet (Example: #ACCIntl, #ACCFIT, #WomenInCardiology, #CVD, #HeartFailure). You may also review our hashtag guide (https://www.acc.org/-/media/Non-Clinical/Files-PDFs-Excel-MS-Word-etc/About-ACC/Social-Media/ACC-Social-Media-Hashtag-Reference-Guide.pdf). Please note that the editors will review your content, and it may not ultimately be published on the Please note that the editors will review your content, and it may not ultimately be published on the @JACCJournals Twitter account: https://twitter.com/JACCJournals
Acknowledgements: 100 words or less.

Abstract

Provide a structured abstract of no more than 250 words for Original Investigations, presenting essential data in 5 paragraphs introduced by separate headings in the following order: Background, Objectives, Methods, Results, Conclusions. All data in the abstract also must appear in the manuscript text or tables.

An unstructured 150-word abstract should be provided for review articles and long-form primers.

Keywords

Immediately after the abstract, provide a maximum of 6 key words, using American spelling and avoiding general and plural terms and multiple concepts (avoid, for example, 'and', 'of'). Be sparing with abbreviations. These key words will be used for indexing purposes, and therefore should be different than the terms/words already used in the title of the paper.

Abbreviations

Up to 10 abbreviations (e.g., ECG, PTCA, CABG) or acronyms (GUSTO, SOLVD) may be listed. On a separate page following the abstract, list the selected abbreviations and their definitions (e.g., TEE = transesophageal echocardiography). The editors will determine which lesser-known terms should not be abbreviated. Consult "Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals (ICMJE Recommendations)," available at http://www.icmje.org,for appropriate use of units of measure.

Text

Use Times New Roman 12-point font. All text from the Introduction to the end of the manuscript should be double-spaced. Page numbering should start with the Title Page. The text for Original Research papers should be structured as: Introduction, Methods, Results, Discussion, and Conclusions. Use headings and subheadings in the Methods, Results, and, particularly in the Discussion sections. Every reference, figure, and table should be cited in the text in numerical order according to order of mention. All supplemental figures, tables, videos and appendices should also be cited in the text.

Clinical Perspectives

These are for original investigations only.

The authors should delineate clinical implications/competency in medical knowledge or patient care and translational outlook recommendations for their manuscripts. These should be listed in the manuscript after the Text and before the References. Please review the examples provided below.

The implications describe the consequences of the study for current practice. The translational outlook identifies the potential barriers to clinical translation, emphasizing directions for additional research.

Competency in Medical Knowledge or Competency in Patient Care. Competency-based learning in cardiovascular medicine addresses the 6 domains promulgated by the Accreditation Council on Graduate Medical Education (ACGME) and endorsed by the American Board of Internal Medicine (Medical Knowledge, Patient Care and Procedural Skills, Interpersonal and Communication Skills, Systems-Based Practice, Practice-Based Learning, and Professionalism) (htttp://www.acgme.org/acgmeweb). The ACCF has adopted this format for its competency and training statements, career milestones, lifelong learning, and educational programs. The ACCF also has developed tools to assist physicians in assessing, enhancing, and documenting these competencies http://www.acc.org/education-and-meetings/products-and-resources/competencies. Authors are asked to consider the clinical implications of their report and identify applications in one or more of these competency domains that could be used by clinician readers to enhance their competency as professional caregivers and the potential impact on the clinical care of cancer patients. This applies not only to physicians in training, but to the sustained commitment to education and continuous improvement across the span of their professional careers.

Translational Outlook.Translating biomedical research from the laboratory bench, clinical trials or global observations to the care of individual patients can expedite discovery of new diagnostic tools and treatments through multidisciplinary collaboration. Effective translational medicine facilitates implementation of evolving strategies for prevention and treatment of disease in the community. The Institute of Medicine identified two areas needing improvement: testing basic research findings in properly designed clinical trials and, once the safety and efficacy of an intervention has been confirmed, more efficiently promulgating its adoption into standard practice (Sung NS, Crowley WF, Genel M. The meaning of translational research and why it matters. JAMA 2008;299:3140-3148). The National Institutes of Health (NIH) has recognized the importance of translational biomedical research, emphasizing multifunctional collaborations between researchers and clinicians to leverage new technology and accelerate the delivery of new therapies to patients (htttp://www.ncats.nih.gov/about/). Authors are asked to place their work in the context of the scientific continuum, by identifying impediments and challenges requiring further investigation and anticipating next steps and directions for future research. Authors should briefly reflect on how their work potentially impacts the clinical care of cancer patients.

Example 1:

Competencies in Medical Knowledge:In patients treated for breast cancer with doxorubicin with or without trastuzumab, early changes in circulating levels of thearginine-nitric oxide metabolites arginine, asymmetric dimyethylarginine, and monomethylarginine are associated with cardiac dysfunction.
Translational Outlook: Further research is needed to assess the prophylactic and therapeutic utility of measuring these biomarkers of oxidative stress in women with breast cancer undergoing anthracycline chemotherapy.

Example 2:

Competencies in Medical Knowledge: In patients receiving immune checkpoint inhibitors therapy for cancer, myocarditis develops at a median of 34 days. Elevation of serum troponin levels may signal the need to consider myocarditis. Checking troponin levels at baseline and at each 21-day infusion cycle or at alternate cycles for those receiving 14-day infusion therapy may be useful.
Translational Outlook: Future studies should determine the response of ICI-related myocarditis to escalating doses of corticosteroids and other immunotherapies such as infliximab, intravenous immunoglobulin, mycophenolate, and antithymocyte globulin.

Highlights

These are for State-of-the-Art Reviews and Primers Only.

Please provide a list of 3-4 brief (of no more than 15 words each) bullet points that highlight the main messages of the review. The first bullet should provide the translational/clinical context or background that establishes the relevance or need for this review. The second bullet should speak to the main message and focus of the review, including any recommendations made by the authors. The final bullet should summarize where the field needs to move forward from this point.

Example

Calorie reduction and adjusted diurnal rhythm of feeding may help to prevent cardiovascular disease.
Lowered intake of protein and nutritional modulation of the gut microbiome can be cardioprotective.
Regular exercise, stress-reduction programs, and calorie-restriction mimetic medications can impact a healthy diet.

References

Identify references in the text using superscript numerals without parentheses.
The reference list should be double-spaced on pages separate from the text; references must be numbered consecutively in the order in which they are mentioned in the text. List all authors if 6 or fewer, otherwise list the first 3 and add "et al." Do not use periods after author initials.
Do not cite personal communications, manuscripts in preparation, or other unpublished data in the references; these may be cited in the text in parentheses. Do not cite abstracts that are older than 2 years. Identify abstracts by the abbreviation "abstr" in parentheses. If letters to the editor are cited, identify them with the word "letter" in parentheses. Websites must be cited as references (i.e. any URLs cited in the text or tables must be included as references rather than in the text or table).
Use Index Medicus (National Library of Medicine) abbreviations for journal titles. When citing an article from JACC: CardioOncology, the correct citation format is JACC CardioOncol.
Please do not cite references more than 10 years old, unless there is a very specific purpose
Use the following style and punctuation for references:

Periodical. Do not use periods after the authors' initials. Please provide inclusive page numbers: Example: "5. Barac A,Murtagh G, Carver JR, et al. Cardiovascular health of patients with cancer and cancer survivors: a roadmap to the next level. J Am Coll Cardiol 2015;65:2739-2746.""
DOI-based citation for an article in press.
- If the ahead-of-print date is known, please provide. EXAMPLE: "16. Bhatt DL, Steg PG, Miller M, et al., for the REDUCE-IT Investigators Effects of icosapent ethyl on total ischemic events: from REDUCE-IT. J Am Coll Cardiol. 2019 March 18 [E-pub ahead of print]. https://doi.org/10.1016/j.jacc.2019.02.032."
- If the ahead-of-print date is unknown, please omit. EXAMPLE: "16. Bhatt DL, Steg PG, Miller M, et al., for the REDUCE-IT Investigators Effects of icosapent ethyl on total ischemic events: from REDUCE-IT. J Am Coll Cardiol. 2019 [E- pub ahead of print]. https://doi.org/10.1016/j.jacc.2019.02.032."
Chapter in book. Provide author(s), chapter title, editor(s), book title, publisher location, publisher name, year, and inclusive page numbers. EXAMPLE: "27.Masoudi F, Rumsfeld J, Measuring and Improving Quality of Care: Relevance to Cardiovascular Clincal Practice. In: Zipes D, Libby P, Bonow R, Mann D, Tomaselli G, Braunwald E, editors. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th edition. Philadelphia, PA: Elsevier, 2018: 33 - 38."
Book (personal author or authors.) Provide a specific (not inclusive) page number. EXAMPLE: "23. Lilly L. Pathophysiology of Heart Disease: A Collaborative Project of Medical Students and Faculty. 6th edition. Philadelphia, PA: Wolters Kluwer, 2016:33."
Online media. Provide specific URL address and date information was accessed. EXAMPLE: "41. American College of Cardiology. ACC Roundtable Explores the Emerging Field of Cardio-Oncology. 2018. Available at https://www.acc.org/latest-in-cardiology/articles/2018/02/27/17/18/acc-roundtable-explores-the-emerging-field-of-cardio-oncology. Accessed July 20188."
Material presented at a meeting but not published. Provide authors, presentation title, full meeting title, meeting dates, and meeting location. EXAMPLE: "20. Rollman B. Blended Collaborative Care for Treating Heart Failure and Co-Morbid Depression - Hopeful Heart. Presented at: American College of Cardiology Annual Scientific Sessions; March 16, 2019; New Orleans, LA."

AMA Manual of Style The JACC Journals follow the AMA Manual of Style with minor modifications. This guide provides guidance on usage, including but not limited to sociodemographic descriptors and nomenclature. For more detailed information on what’s new in the 11th edition, see the slide set here: https://www.amamanualofstyle.com/page/aboutAMAMOS11.

Figure Legends

All figures must have a number, title, and caption. Figure legends should explain each figure, and include a TITLE for each figure, and a respective CAPTION that includes the purpose of the figure, and brief method, results, and discussion statements pertaining to the figure. All abbreviations used in the figure should be identified either after their first mention in the legend or in alphabetical order at the end of each legend. All symbols used in the Figure (arrows, circles, etc.) must be explained. Target length should be 50-100 words per figure, with the title no more than 10 words. Legends should not exceed 150 words. See also Figures/Central Illustration, below.

Figures should be cited in numerical order in the text. Please also cite the Central Illustration if applicable.
Supplemental figures should be cited as "Supplemental Figure 1, Supplemental Figure 2," etc.
Figure titles should be short and followed by a 2 to 3 sentence caption.
Your Central Illustration, if not an existing figure, should be listed last and include both a TITLE and a CAPTION as outlined above.
If the figure has been previously published, cite the figure source in the legend and provide any necessary permission to reuse.
All abbreviations used in the figure should be identified in alphabetical order at the end of each legend (see also Figures).

Tables

Each table should be on a separate page, with the table number and title centered above the table and explanatory notes below the table. Use Arabic numbers. Table numbers must correspond with the order cited in the text. Tables should be self-explanatory, and the data presented in the tables should not be duplicated in the text or figures.

All tables must have a title of up to 15 words.
Each table may include a caption of up to 100 words. Abbreviations, which do not count toward the caption word limit, should be listed in a footnote under the table in alphabetical order.
Footnote symbols should use lowercase, superscript letters, in alphabetical order: ^a, ^b, ^c, etc.
If previously published tables are used, written permission from the original publisher/author is required.
Cite the source of the table in the footnote.

Figures/Central Illustrations

ALL ORIGINAL INVESTIGATIONS, STATE OF THE ART REVIEWS, AND LONG-FORM PRIMERS SHOULD INCLUDE A CENTRAL ILLUSTRATION.

Central Illustrations serve to succinctly summarize the entire manuscript or at least a major section of the manuscript. Upon acceptance, our in-house medical illustrators will assist in creating the final versions of these figures in consultation with the authors and the editors. The purpose of these illustrations is to provide a snapshot of your paper in a single visual, conceptual manner.

This illustration must be accompanied by a legend consisting of a title and caption of no more than 50-100 words in total. The title should be no more than 10 words. The Central Illustration legend should be listed last in your list of figure legends. For best practices on creating Central Illustrations, please see The Art and Challenge of Crafting a Central Illustration or Visual Abstract at https://www.jacc.org/doi/full/10.1016/j.jacc.2019.10.035

Figure Requirements for All Figures

All figures must have a title and caption.
TIFF figures are preferred.
Color and gray scale images must be at least 300 DPI.
Figure numbers must correspond with the order in which they are mentioned in the text.
If previously published figures are used, written permission from the original publisher is required. See STM Guidelines for details: https://www.stm-assoc.org/intellectual- property/permissions/permissions-guidelines/
If any figure has been previously published, cite the figure source in the legend.
Please remove trial logos from figures.

Graphics software, such as Photoshop and Illustrator, should be used to create the art, but not presentation software such as PowerPoint, CorelDraw, or Harvard Graphics. Line art (black and white or color) and combinations of gray scale images and line art should be at least 1200 DPI. Lettering should be of sufficient size to be legible after reduction for publication. The optimal size is 12 points. Symbols should be of a similar size. Figures should be no smaller than 13 cm x 18 cm (500 x 700). Decimals, lines, and other details must be strong enough for reproduction. Use only black and white-not gray-in charts and graphs. Place crop marks on photomicrographs to show only the essential field. Designate special features with arrows. All symbols, arrows, and lettering on half-tone illustrations must contrast with the background.

There is no fee for the publication of color figures. Our editors encourage authors to submit figures in color, as we feel it improves the clarity and visual impact of the images.

Supplemental Material

Supplemental material should be essential to the understanding and interpretation of the primary manuscript, and should contain original content that has not been previously published. The supplemental material will be posted online at the same time of publication of the article.

Please upload all supplemental materials, with the exception of videos and large data sets (see below), as one separately uploaded Word document that is labeled “Supplemental Appendix.” The pages of the Supplemental Appendix should be numbered consecutively. The first page of the Supplemental Appendix should list the title of the manuscript and the contents of the supplement, including the title and page number of each element included in the document.

The Supplemental Appendix document may include the following elements:

Supplemental methods
Supplemental results
Supplemental tables (e.g., Supplemental Table 1, Supplemental Table 2)
Supplemental figures with accompanying figure legends (e.g., Supplemental Figure 1, Supplemental Figure 2)

All references that are cited within supplemental material should be placed in a separate reference section that is at the end of the supplemental material. The references should be formatted just as in the main manuscript and numbered and cited consecutively in the Supplemental Appendix.

All supplemental material will undergo editorial and peer review at the same time as the main manuscript is being evaluated. Once the manuscript is accepted for final publication, the content of the supplemental material cannot be changed.

Videos

Inclusion of videos in the published paper is at the discretion of the editors.

Video submissions for viewing online should be submitted as MP4 files only. The journal office will not accept any other file formats.
Videos should be no larger than 15MB. Larger videos will require longer download times and may have difficulty playing online.
A video legends page giving a brief description of the content of each video must be included in the manuscript. Please list the video legends page immediately after the figure legends page in the manuscript.

Permissions

If a figure/table is reprinted or adapted from a previously published work, permission must be obtained from that publisher (or copyright holder, if not the publisher) and sent to the editorial office. Please also see Figures/Central Illustrations. If a manuscript includes excerpts of published text longer than 50 words, permission from the copyright holder to republish the text is required.

Editorial Policies

All manuscripts must be submitted online at https://www.jaccsubmit-cardiooncology.org. By submitting an article to the journal, all authors of the submission agree to receive emails from all the American College of Cardiology's JACC Journals regarding the manuscript, including editorial queries while the manuscript is under review and emails from the publisher should the paper be accepted for publication. The contact information provided by the corresponding author will be included in the galley proofs, the published PDF version of the manuscript, and the online version of the manuscript.

Ethics

Manuscript submissions should conform to the guidelines set forth in the "Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals," available online at http://www.icmje.org/recommendations.

Studies should be in compliance with human studies committees and animal welfare regulations of the authors' institutions and the U.S. Food and Drug Administration guidelines. Human studies must be performed with the subjects' written informed consent. Authors must provide the details of this procedure and indicate that the institutional committee on human research has approved the study protocol. If radiation is used in a research procedure, the radiation exposure must be specified in the Methods.

Clinical trials should be registered. Studies on patients or volunteers require ethics committee approval and informed consent which should be documented in your paper. Patients have a right to privacy. Therefore, identifying information, including patients' images, names, initials, or hospital numbers, should not be included in videos, recordings, written descriptions, photographs, and pedigrees unless the information is essential for scientific purposes and you have obtained written informed consent for publication in print and electronic form from the patient (or parent, guardian or next of kin where applicable).

If such consent is made subject to any conditions, the editorial office must be made aware of all such conditions. Written consents must be provided to the editorial office on request. Even where consent has been given, identifying details should be omitted if they are not essential.

If identifying characteristics are altered to protect anonymity, such as in genetic pedigrees, authors should provide assurance that alterations do not distort scientific meaning and editors should so note. If such consent has not been obtained, personal details of patients included in any part of the paper and in any supplementary materials (including all illustrations and videos) must be removed before submission.

Animal investigation must conform to the "Position of the American Heart Association on Research Animal Use," adopted by the AHA on November 11, 1984. If equivalent guidelines are used, they should be indicated. The AHA position includes: 1) animal care and use by qualified individuals, supervised by veterinarians, and all facilities and transportation must comply with current legal requirements and guidelines; 2) research involving animals should be done only when alternative methods to yield needed information are not possible; 3) anesthesia must be used in all surgical interventions, all unnecessary suffering should be avoided and research must be terminated if unnecessary pain or fear results; and 4) animal facilities must meet the standards of the American Association for Accreditation of Laboratory Animal Care (AAALAC).

The JACC Journals have an ethics committee comprised of 7 members, which oversees quality control and will look into the issues of concern, if any.

Ethical Approval:. Ethical Approval: Please denote that your study received the proper ethical oversight in both your cover letter and the first paragraph of your Methods section. For manuscripts reporting data on human subjects, note institutional review board/ethics committee approval (or formal review and exemption), including the specific name of the board or committee. For studies involving animal experiments, note that the study complied with all institutional and national requirements for the care and use of laboratory animals and, if applicable, received animal care and use committee approval. State the animal-handling protocol in your Methods.

Research Data

This journal encourages and enables you to share data that supports your research publication where appropriate and enables you to interlink the data with your published articles. Research data refers to the results of observations or experimentation that validate research findings. To facilitate reproducibility and data reuse, this journal also encourages you to share your software, code, models, algorithms, protocols, methods and other useful materials related to the project. For more information on depositing, sharing and using research data and other relevant research materials, visit the research data page: https://www.elsevier.com/authors/author-services/research-data

Data statement: To foster transparency, we encourage you to state the availability of your data in your submission. If your data is unavailable to access or unsuitable to post, you will have the opportunity to indicate why during the submission process, for example by stating that the research data is confidential. For more information, visit the Data Statement page: https://www.elsevier.com/authors/author-services/research-data/data-profile

Relationship with Industry Policy

All authors are required to disclose any relationship with industry and other relevant entities-financial or otherwise-within the past 2 years that might pose a conflict of interest in connection with the submitted article. All relevant relationships with industry, disclosures, and sources of funding for the work should be acknowledged on the title page, as should all institutional affiliations of the authors (including corporate appointments). This includes associations such as consultancies, stock ownership, or other equity interests or patent-licensing arrangements. If no relationship with industry exists, please state this on the title page.

All forms are now signed and submitted electronically. Once a manuscript is accepted, the authors will be sent links to complete the electronic Relationship with Industry forms. Elsevier now handles copyright for the journal. Only the corresponding author may electronically sign the copyright form; however, all authors are required to electronically sign a relationship with industry form. Once completed, a PDF version of the form is e-mailed to the author. Authors can access and confirm receipt of forms by logging into their account at https://www.jaccsubmit-cardiooncology.org. Each author will be alerted if his or her form has not been completed by the deadline.

The JACC Journals program prefers the term Relationships with Industry and Other Entities as opposed to the term Conflict of Interest, because, by definition, it does NOT necessarily imply a conflict. When all relationships are disclosed with the appropriate detail regarding category and amount, and managed appropriately for building consensus and voting, the JACC Journals program believes that potential bias can be avoided and the final published document is strengthened since the necessary expertise is accessible.

Disclosure of AI Programs

Please disclose in the cover letter and in the acknowledgement section (the latter of which is published, if the paper is accepted) if any artificial intelligence (AI) programs (e.g., ChatGPT, or other similar software) contributed to the compilation of the submitted manuscript as well as the nature of the contribution that the tool provided. This could include design, performance, analysis, writing, and reporting of the work.

Copyright

On acceptance, transfer of copyright to the author(s) will occur (for more information see https://www.elsevier.com/about/policies/copyright). Permitted third party reuse of open access articles is determined by the author's choice of user license (see https://www.elsevier.com/about/policies/open-access-licenses). As an author you (or your employer or institution) have certain rights to reuse your work. For more information on author rights please see https://www.elsevier.com/about/policies/copyright

Review Process and Decisions

JACC: CardioOncology uses a single-blind peer-review system, meaning that the authors are blinded to the identity of the reviewers and as a general rule, although there are exceptions, the reviewers are blinded to each other. While the JACC:CardioOncology Associate Editor may be identified at the end of the review process, all correspondence concerning a manuscript should be addressed to the JACC:CardioOncology editorial staff at jaccco@acc.org. At initial submission, a manuscript is reviewed by editorial staff for compliance with journal style and to make sure the submission is clear and legible for reviewers and editors. Once the editorial staff have checked in the paper, it is assigned to the JACC:CardioOncology Editor-in-Chief, who will assign it to an Associate Editor. The Associate Editor then determines if it should be sent for peer review or if it is not of sufficient priority for JACC:CardioOncology. All reviewers and editors are asked to report any potential conflicts of interest, and when those exist the manuscript is reassigned to a different editor or reviewer. Once 2 reviews have been completed, the submission is reviewed by all JACC:CardioOncology associate editors in a weekly meeting. The group then comes to one of the four decisions below:

Accept. The manuscript is acceptable for publication in its current form. However, minor edits may be made by the JACC:CardioOncology medical editors, illustrators, or the publisher, and authors will need to work to ensure these changes are made post-acceptance.
Minor Revision. It is important to note that this decision does not guarantee acceptance. However, less significant edits are required than a Revision Required decision.
Revision Required. The manuscript is unacceptable for publication in its current form. However, the editors are willing to reconsider a thoroughly revised manuscript. The authors must respond to all reviewer and editor comments and the submission will be re-reviewed and treated as a new submission.

Reject. The manuscript is unacceptable for publication and/or is not an appropriate fit for JACC:CardioOncology.

Guest Editors: Editors are not involved in decisions about papers which they have written themselves or have been written by family members or institutional colleagues or which relate to products or services in which the editor has an interest. Any such submission is subject to all of the journal's usual procedures, with peer review handled independently of the relevant editor and their research groups.

Statistics

All publishable manuscripts will be reviewed for appropriateness and accuracy of statistical methods and statistical interpretation of results. We subscribe to the statistics section of the "Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals (ICMJE Recommendations)," available at http://www.icmje.org. In the Methods section, provide a subsection detailing the statistical methods, including specific methods used to summarize the data, methods used for hypothesis testing (if any), and the level of significance used for hypothesis testing. When using more sophisticated statistical methods (beyond t tests, chi-square, simple linear regression), specify the statistical package, version number, and nondefault options used. For more information on statistical review, see "Glantz SA. It is all in the numbers. J Am Coll Cardiol 1993;21:835-7."

Expedited Review

In order for Original Investigations to be considered for expedited review, they should report important original findings of high-potential clinical impact or research significance. Authors should request expedited review and the rationale for this request in their cover letter at the time of submission. The editors commit to a decision regarding suitability for expedited publication processing within 2 days, and an initial decision within 14 days. Those manuscripts not deemed appropriate for the expedited publication track will be considered according to the standard review process. We always inform authors whether we are able to offer expedited review. An agreement to provide expedited review does not guarantee acceptance.

Appeals

Authors may appeal editorial decisions by email. To appeal a decision, send your rationale as to why the editors should reconsider the paper to jaccco@acc.org. The rationale should address all of the reviewers' concerns. The editors may grant or deny the appeal, and their decision is final. Appeals must be submitted within 30 days of the date the decision was rendered.

JACC Journals Publication Integrity Guidelines

JACC Journals have adopted integrity guidelines to help authors uphold the ethics, values, and principles of the publication process at the highest standards. The guidelines below include best practices and are consistent with those implemented by other journals and scientific publishers.

Plagiarism

The Office of Research Integrity (ORI) defines plagiarism as "theft or misappropriation of intellectual property and the substantial unattributed textual copying of another's work." Manuscripts where unacknowledged copying of others' ideas, language and/or results will not be published in JACC Journals and, depending on level of egregiousness, will be reported to ORI and/or other agencies. Therefore, authors should ensure that appropriate attribution and citation is provided when discussing, paraphrasing, or summarizing the work of others. Included is the use of one's own text from previous publications (exclusive of materials and methods), where appropriate attribution and citation is necessary. Reuse of one's own or others' previously published data, whether it be publishing the same paper in multiple journals or adding incremental new data to a previous publication without providing appropriate references, will be considered a duplicate publication.

Should JACC Journals discover acts of plagiarism pre-publication, the publication process will be halted until the matter is resolved. Should JACC Journals discover acts of plagiarism post-publication, an investigation to determine the extent and context of the plagiarism will be conducted. JACC Journals reserve the right to correct or retract any publication based on the findings of said investigations.

Due credit for unpublished and published work

Authors must discuss, properly cite, and provide appropriate permissions for any unpublished work included in submitted manuscripts. Any data, intellectual contribution, and/or technical development, including unpublished data from databases, must be acknowledged and appropriately cited. Authors must include written assurance that they are complying with the data-licensing agreements of the original source documents when using licensed data. If an author is reusing or modifying previously published or copyrighted figures, documented permission from the previous publisher or copyright holder is required.

Duplicate publication

Material submitted to a JACC Journal must be original. Submitted material cannot have been previously published and cannot be simultaneously submitted elsewhere (exclusive of meeting abstracts). Related manuscripts under consideration or in press elsewhere must be declared by authors submitting to a JACC Journal at the time of submission in the cover letter. If related material is submitted elsewhere after submission to a JACC Journal, authors must notify the JACC Journal immediately.

Data Integrity

All data and figures published in JACC Journals must accurately represent the original data and findings. Misrepresentation of data acquisition and/or post-acquisition processing is not acceptable.

While JACC Journals understand minor data processing may be unavoidable, submitted digital images must be as close to original as possible. Processing/image adjustment (e.g., contrast or brightness) must be applied equally across the entire image and any relevant controls. Any image processing/adjustment should not make data disappear or mask additional bands. Authors should explain any image alterations in the figure legend and identify image acquisition tools and processing software in the methods. Integral settings and processing manipulations used to process the presented data should also be described.

JACC Journals reserve the right to request all unprocessed data files included in a submitted manuscript. Manuscript evaluation may be halted or discontinued if the files are not available upon request.

Authors should take care to adhere to the following specific concerns:

Electrophoretic gels and blots. Cropped gels must preserve all important bands. Individual images cannot be used in multiple figures except when the figures describe different aspects of the same experiment (e.g., when a single control experiment served serves multiple experiments performed simultaneously). When an image is used in multiple figures, authors must clearly state the reason(s) for this in the figure legend.
Quantitative comparisons between samples on different gels/blots should be avoided, and only performed when normalizing controls are available for both gels. Protein loading controls must be run on the same blot. If unavoidable, the figure legend must indicate that the samples are derived from the same or parallel experiments and that the gels/blots are processed in parallel.

Removal of irrelevant or blank lanes from a gel is permissible; however, such alterations must be noted in the figure legend and boundaries between the nonadjacent or rearranged lanes must be clearly marked in the figure.
Microscopy. A scale bar should be included with all microscopy images. The measured resolution at which an image was acquired and any subsequent processing or averaging that enhances the resolution must be clearly stated. Adjustments should be applied over the entire image.
Microscopy settings for comparable controls and samples should be the same between experiments. Any necessary nonlinear, pseudocolor, or color adjustments made to images must be stated in the figure legend. Any manipulation of threshold and expansion or contraction of signal ranges should be avoided.

Authors should not combine images obtained separately, at different times, or from different locations, into a single image, unless specifically stated in the figure legend.
Data Visualization Guidelines. Figures representing data need to be designed and presented in a way that allows readers to understand and critically interpret the data. Authors must ensure that figures use easily distinguishable colors/lines/symbols and are color-blind-safe.
Continuous data and small sample sizes should be represented with figures that show full data distribution, such as dot or scatter plots. Bar graphs should be avoided except when showing counts or proportions.

Authors should consider adding a flow chart or study design diagram when appropriate. Flow charts should provide information about excluded observations and reasons for exclusion at each phase of the study.
Data Management Guidelines. As outlined by ORI, data management is one of the essential areas of responsible conduct of research (https://ori.hhs.gov/education/products/clinicaltools/data.pdf). Authors are expected to maintain all of the primary data used for their research submission, so that it can be evaluated by the reviewers and editors. At a minimum the retention of data after manuscript publication should conform to the policies within the authors' organization and the funding organization.

Contacting Us

Editorial Office at Heart House

For enquiries relating to submitted articles or to articles currently under review, please contact the JACC editorial office at jaccco@acc.org. All manuscripts must be submitted online at www.jaccsubmit.org. Authors who are having trouble may e-mail jaccco@acc.org or call the number below.
The mailing address for the JACC editorial office and the Editor-in-Chief is:
Bonnie Ky, MD, MSCE, FACC
Editor-in-Chief, Journal of the American College of Cardiology
Heart House, 2400 N Street NW
Washington, DC, 20037
Phone: (202) 375-6136
Fax: (202) 375-6819
E-mail: jaccco@acc.org

Elsevier (Publisher)

For information on articles that have been accepted for publication, please visit Elsevier's Authors Home at https://www.elsevier.com/authors/journal-authors. Elsevier's Authors Home also provides the facility to track accepted articles (http://www.elsevier.com/trackarticle) and set up e-mail alerts to inform you of when an article's status has changed, as well as detailed artwork guidelines, copyright information, frequently asked questions, and more. You are also welcome to contact Customer Support via http://support.elsevier.com. Authors can order copies of the issue in which their article appears at a discounted rate. For this service, please contact:
Elsevier Health Sciences Division
Subscription Customer Service
3251 Riverport Lane
Maryland Heights, MO 63043
Tel: 1-800-654-2452
E-mail: journalscustomerservice-usa@elsevier.com

English language help service: For English language editing services, Elsevier can direct authors upon request to a service that can assist with this prior to submission. Please visit https://webshop.elsevier.com/language-editing-services/language-editing/ for further information.