New insights into active versus passive nanoparticle tumour entry and exit mechanisms are enriching the understanding of tumour-targeted drug delivery. Here we align the principles of enhanced permeability and retention (EPR) and active transport and retention (ATR), and outline how their mechanistic features can be employed to improve the performance and clinical impact of cancer nanomedicines.

Postdoctoral researchers (postdocs), vital contributors to academia, often face vulnerability and uncertainty. Here is a wish list from a fellow postdoc, outlining key measures to improve postdoctoral life — from employment stability and fair compensation to better work-life balance and mentorship.

Stimulation therapy for neuropsychiatric disorders is hindered by the complexity and inter-individual and intra-individual variability in symptom manifestations, neural representations and response to therapy. Brain–computer interfaces could model the brain response to stimulation and decode the symptom state of a patient from brain activity as feedback to personalize the stimulation therapy in closed loop.

Despite inspiring proof-of-concepts that are often widely covered by the media, only a few neurotechnologies have firmly established themselves as clinical solutions. In this Review, we discuss opportunities and shortcomings of this technology, and provide a framework to facilitate clinical and commercial translation.

Brain-on-a-chip models, mimicking brain physiology, hold promise for developing treatments for neurological disorders. This Review discusses the engineering challenges and opportunities for these devices, including the integration of 3D cell cultures and electrodes and scaffold engineering strategies.

New insights into active versus passive nanoparticle tumour entry and exit mechanisms are enriching the understanding of tumour-targeted drug delivery. Here we align the principles of enhanced permeability and retention (EPR) and active transport and retention (ATR), and outline how their mechanistic features can be employed to improve the performance and clinical impact of cancer nanomedicines.

Postdoctoral researchers (postdocs), vital contributors to academia, often face vulnerability and uncertainty. Here is a wish list from a fellow postdoc, outlining key measures to improve postdoctoral life — from employment stability and fair compensation to better work-life balance and mentorship.

Stimulation therapy for neuropsychiatric disorders is hindered by the complexity and inter-individual and intra-individual variability in symptom manifestations, neural representations and response to therapy. Brain–computer interfaces could model the brain response to stimulation and decode the symptom state of a patient from brain activity as feedback to personalize the stimulation therapy in closed loop.

Despite inspiring proof-of-concepts that are often widely covered by the media, only a few neurotechnologies have firmly established themselves as clinical solutions. In this Review, we discuss opportunities and shortcomings of this technology, and provide a framework to facilitate clinical and commercial translation.

An article in Nature Materials reports a new ultrasoft and conformal liquid bioelectronic material for injectable and retrievable biosensing.

Organoid intelligence towards biocomputing may provide insights into the neuroscience of learning and memory, and offer a biohybrid form of information processing. Advances in brain region-specific organoid engineering, sensors and signal-processing tools, integration of artificial intelligence, and miniaturization will pave the way for organoid intelligence to make an impact in biomedicine and beyond.

Prosthetic embodiment, or the incorporation of a prosthesis into one’s sensory and functional body schema, may be achieved by engineering bionic limbs that leverage a closed-loop mechanoneural–machine interface. However, the subjective experience of embodiment remains difficult to define and assess.

University departments may benefit from guidelines not only to craft effective diversity, equity and inclusion plans, but also to measure progress towards achieving specific goals. This Perspective presents a framework for building, assessing and continuously improving strategic plans to improve recruitment and retention and make departments more inclusive.