少食饮食的ADHD儿童脑功能与ADHD症状变化的相关性:一项开放标签的干预试验

2021-11-12 Sci Rep

对营养对儿童注意缺陷多动障碍(ADHD)影响的研究表明,少食饮食(FFD)显著降低了60%儿童的ADHD症状。然而,其机制尚不清楚。在这项开放标签的营养干预研究中,我们调查了79名8-10岁ADHD男

中文标题:

少食饮食的ADHD儿童脑功能与ADHD症状变化的相关性:一项开放标签的干预试验

英文标题:

Correlation between brain function and ADHD symptom changes in children with ADHD following a few-foods diet: an open-label intervention trial

发布机构:

发布日期:

2021-11-12

简要介绍:

对营养对儿童注意缺陷多动障碍(ADHD)影响的研究表明,少食饮食(FFD)显著降低了60%儿童的ADHD症状。然而,其机制尚不清楚。在这项开放标签的营养干预研究中,我们调查了79名8-10岁ADHD男童在服用FFD后的行为变化是否与抑制控制期间的脑功能变化相关。家长在FFD前(t1)和FFD后(t2)完成ADHD评定量表。在t1和t2停止信号任务期间采集功能磁共振成像(fMRI)扫描,并对ARS评分进行盲法初始受试者水平分析。50例(63%)为饮食反应者,ADHD症状减少至少40%。53例患儿进行了足够质量的fMRI扫描以供进一步分析。"感兴趣区分析表明,与停止信号任务相关的脑区激活与ADHD症状变化无关。"然而,全脑分析显示ADHD症状减少与楔前叶激活增加相关(StopSuccess > Go试验p(FWE(群))= 0.015,StopSuccess > StopFail试验p(FWE(群))< 0.001)。这些结果为少食饮食对ADHD儿童的疗效提供了神经认知机制的证据。

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