J Clin Periodontol:胰岛素抵抗肥胖患者患牙周炎几率

2017-10-05 MedSci MedSci原创

我们研究肥胖与牙周炎之间的关系,以确定胰岛素抵抗(IR)在这种关系中可能的作用。

我们研究肥胖与牙周炎之间的关系,以确定胰岛素抵抗(IR)在这种关系中可能的作用。

材料和方法:共有212例受试者(110名肥胖和102名贫困个体)进行牙周病评估,并根据IR分为:无IR组(LWIR),无IR(OWIR)肥胖组和IR(OIR)肥胖组。评估人体测量,代谢,炎症和牙周参数。

结果:肥胖(80.9%)患牙周炎的患者比健康人群(41.2%)更为普遍,前者患牙周炎风险增加了6倍。肥胖受试者整体舒张压,TNFα和hsCRP升高和HDL胆固醇较低。 OIR比OWIR有更高的收缩压,葡萄糖,胰岛素,HOMA-IR,A1c,甘油三酯和牙齿数目,其他牙周变量没有改变。多变量回归模型显示探诊深度,探查出血和HOMA-IR均为PD≥4mm的牙齿数的独立预测因子。

结论:我们的数据支持肥胖和牙周炎之间的关联,并指出IR的核心作用。在IR患者中,牙周炎的发病率更高。

原始出处:

Mayte Martinez-Herrera, Francisco Javier Silvestre, et al. Involvement of insulin resistance in normoglycaemic obese patients with periodontitis: A cross-sectional study. Journal of Clinical Periodontology. 2017 October. doi: 10.1111/jcpe.12773

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    2018-05-25 feather89
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    2018-06-21 baoya
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    2017-10-05 天涯183

    非常好的文章.学习了

    0

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    2017-10-05 1e0e5697m83(暂无匿称)

    henhao

    0

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    2017-10-05 中医痴

    不错的.学习了.谢谢分享!

    0

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在非酒精性脂肪性肝病(NAFLD)中,经常发现氨基酸(AA),特别是支链(BCAA)的血浆浓度增加。然而,这一现象是否是由于增加的肌肉蛋白质分解代谢,肥胖和/或胰岛素抵抗(IR)增加或是由于受损的组织代谢导致的仍然尚未可知。针对这一问题,近期,一项发表在杂志Hepatology上的研究评估了a)与肥胖的NAFLD者(NAFLD-Ob)相比,非肥胖NAFLD(NAFLD-NO)的受试者与对照组(CT

Cell:科学家从外泌体中发现糖尿病胰岛素抵抗的机制

由肥胖导致的慢性组织炎症是胰岛素抵抗和2型糖尿病的根本原因。但迄今为止,其作用机制仍待阐明。在9月21日刊登在《细胞》杂志上的论文中,美国加州大学圣地亚哥分校(UCSD)医学院的研究人员确定了外泌体(Exosome),也即多种细胞分泌到胞外的极小的膜状脂质囊泡,是炎症和糖尿病之间缺失的环节。

SCI REP:非糖尿病个体血清叶酸水平与胰岛素抵抗相关!

由此可见,该研究的结果表明血清叶酸水平与非糖尿病患者的胰岛素抵抗之间存在负相关性。

Am J Clin Nutr:补充镁可降低胰岛素抵抗、糖尿病前期或非传染性慢性疾病患者血压

补充镁元素对人体的健康有重大意义。2017年9月,发表在《Am J Clin Nutr》上的一项研究调查了补充镁对胰岛素抵抗、糖尿病前期或非传染性慢性疾病患者的血压(BP)影响。结果表明,补充镁显着降低胰岛素抵抗、糖尿病前期或其他非传染性慢性疾病患者的BP。

Diabetologia:无缺失癌胚抗原相关细胞粘附分子2的雄性小鼠中年龄依赖性胰岛素抵抗如何?

近日,国际杂志 《Diabetologia》上在线发表一项关于无缺失癌胚抗原相关细胞粘附分子2基因的雄性小鼠中年龄依赖性胰岛素抵抗的研究。