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Sci Rep：纳米颗粒对枯草芽孢杆菌（3610）能力的影响

2018-02-28 MedSci MedSci原创

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由于其独特的物理化学特性，纳米材料在工业和医疗领域的应用逐年增加。与此同时，越来越多的细菌对许多抗生素产生抗药性，主要是通过水平基因转移过程，这是一个重大的公共卫生问题。本研究首次报道了纳米颗粒在细菌中水平基因转移的生理诱导中的作用。除了已知的纳米颗粒对细菌的作用外，即死亡或氧化应激，纳米颗粒n-ZnO和n-TiO2通过改变参与诱导能力来明显或相反影响枯草芽孢杆菌在生物膜生长条件下的转化效率。这种

由于其独特的物理化学特性，纳米材料在工业和医疗领域的应用逐年增加。与此同时，越来越多的细菌对许多抗生素产生抗药性，主要是通过水平基因转移过程，这是一个重大的公共卫生问题。本研究首次报道了纳米颗粒在细菌中水平基因转移的生理诱导中的作用。

除了已知的纳米颗粒对细菌的作用外，即死亡或氧化应激，纳米颗粒n-ZnO和n-TiO2通过改变参与诱导能力来明显或相反影响枯草芽孢杆菌在生物膜生长条件下的转化效率。这种效应是生理适应而不是物理细胞损伤的结果：两种寡肽ABC转运蛋白OppABCDF和AppDFABC在响应纳米颗粒时表达存在差异。有趣的是，第三种测试纳米粒子，n-Ag，在此实验条件下并没有明显的作用。

总的来说，这些结果表明，通过改变细菌生理学特别是能力，纳米颗粒可能在某些区域产生深远的影响，例如细菌中抗生素抗性的传播。

原始出处：

Elise Eymard-Vernain, Sylvie Luche, et al., Impact of nanoparticles on the Bacillus subtilis (3610) competence. Sci Rep. 2018; 8: 2978.

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    2018-06-29 chengjn

    #芽孢杆菌#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2075834, encodeId=752920e583431, content=<a href='/topic/show?id=95b586964dd' target=_blank style='color:#2F92EE;'>#芽孢杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86964, encryptionId=95b586964dd, topicName=芽孢杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69cb413, createdName=chengjn, createdTime=Fri Jun 29 09:46:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293171, encodeId=be602931e182, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Mon Mar 05 08:36:28 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323382, encodeId=b15f132338206, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Fri Mar 02 10:46:00 CST 2018, time=2018-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292090, encodeId=7f1a29209011, content=好好学习吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSnicyibWfBTADUOjice1wnN8fal65AictjJzXuPFfriafV33NLPOQ6DiahyynUTFBZIrsPTAKwxp2ZbwlshWlCPTEvKiaaibEmr478vA/0, createdBy=3a912053405, createdName=137****8002, createdTime=Thu Mar 01 21:13:22 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291781, encodeId=4edb291e8108, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Feb 28 20:48:22 CST 2018, time=2018-02-28, status=1, ipAttribution=)]
    2018-03-05 yfjms

    学习

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2075834, encodeId=752920e583431, content=<a href='/topic/show?id=95b586964dd' target=_blank style='color:#2F92EE;'>#芽孢杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86964, encryptionId=95b586964dd, topicName=芽孢杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69cb413, createdName=chengjn, createdTime=Fri Jun 29 09:46:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293171, encodeId=be602931e182, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Mon Mar 05 08:36:28 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323382, encodeId=b15f132338206, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Fri Mar 02 10:46:00 CST 2018, time=2018-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292090, encodeId=7f1a29209011, content=好好学习吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSnicyibWfBTADUOjice1wnN8fal65AictjJzXuPFfriafV33NLPOQ6DiahyynUTFBZIrsPTAKwxp2ZbwlshWlCPTEvKiaaibEmr478vA/0, createdBy=3a912053405, createdName=137****8002, createdTime=Thu Mar 01 21:13:22 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291781, encodeId=4edb291e8108, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Feb 28 20:48:22 CST 2018, time=2018-02-28, status=1, ipAttribution=)]
    2018-03-02 ms3117646317107274

    #纳米颗粒#

    0

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    2018-03-01 137****8002

    好好学习吧

    0

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    2018-02-28 1e1b8538m79(暂无匿称)

    不错的文章值得拥有

    0