Ann Rheum Dis:中度维生素D缺乏可独立预测中老年人5年内膝关节疼痛的发生或加重

2014-03-30 MedSci MedSci原创

      澳大利亚一项研究表明,中度维生素D缺乏可独立预测中老年人5年内膝关节疼痛的发生或加重。文章发表于《风湿病学年鉴》[Ann Rheum Dis 2014,73(4):697]杂志4月刊。         研究随机纳入769名50~80岁的中老

      澳大利亚一项研究表明,中度维生素D缺乏可独立预测中老年人5年内膝关节疼痛的发生或加重。文章发表于《风湿病学年鉴》[Ann Rheum Dis 2014,73(4):697]杂志4月刊。

        研究随机纳入769名50~80岁的中老年人。评估受试者基线血清25-羟维生素D(25-OHD)水平,使用西安大略和麦克马斯特大学骨关节炎指数(WOMAC)问卷评估受试者基线、2.6年和(或)5年后的关节疼痛情况并进行线性回归分析。

        结果为,膝关节平均WOMAC总分为3.2分。4.2%的受试者为基线时中度维生素D缺乏[25-OHD为 (12.5~25)nmol/L]。25-OHD<25nmol/L可预测5年内膝关节疼痛变化(β=2.41, P=0.002)。上述相关性不依 赖于人口统计学、人体测量学及结构协变量。

原始出处:

Laslett LL, Quinn S, Burgess JR, Parameswaran V, Winzenberg TM, Jones G, Ding C.Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study.Ann Rheum Dis. 2014 Apr 1;73(4):697-703.

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