JASN:空气污染居然能影响肾脏病!

2016-12-14 haofan MedSci原创

在这个大型系列肾脏活检研究中,在研究期间膜性肾病发生频率的增加,并且长期暴露于高水平的PM2.5与膜性肾病的风险增加相关。

空气污染对肾小球疾病模式变化的影响尚未有研究报道。近日,肾脏病领域权威杂志Journal of the American Society of Nephrology发表一篇来自中国广州南方医科大学南方医院肾内科侯凡凡教授及其团队的研究文章,旨在明确长期空气污染与肾脏病之间的关系。

研究人员评估了肾小球疾病随着时间的变化情况,该研究于2004年至2014年期间在中国282座城市的938家医院中进行,研究者在这11年期间共纳入了71,151例患者,进行了一系列肾脏活检,并评估了长期暴露于细颗粒物(小于2.5μm,PM2.5)与肾小球疾病之间的相关性。对年龄和地区进行标准化后,研究者发现IgA肾病是肾小球疾病的主要类型,发生率为28.1%,其次为膜性肾病,其发生率为23.4%。


值得注意的是,在11年的研究期间,膜性肾病调整后的比值为每年增加13%,而其他主要类型的肾小球疾病比例保持稳定。在研究期间,3年平均暴露的PM2.5在282个城市中变化情况为从6到114μg/m3(平均为52.6μg/m3)。在PM2.5>70μg/m3的地区,PM2.5浓度每增加10μg/m3与膜性肾病比值增加14%相关(比值比为1.14;95%可信区间为1.10-1.18)。研究者还发现,较高的3年平均空气质量指数与膜性肾病的风险增加相关。

总之,在这个大型系列肾脏活检研究中,在研究期间膜性肾病发生频率的增加,并且长期暴露于高水平的PM2.5与膜性肾病的风险增加相关。

原始出处:

Xin Xu,et al. Long-Term Exposure to Air Pollution and Increased Risk of Membranous Nephropathy in China. J Am Soc Nephrol. 2016 Dec.

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    2017-03-23 chenhongpeng
  2. [GetPortalCommentsPageByObjectIdResponse(id=1941290, encodeId=2210194129089, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Thu Mar 23 03:47:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=163855, encodeId=5b061638558e, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Dec 18 18:50:59 CST 2016, time=2016-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=163611, encodeId=4ce6163611ee, content=这个影响可就大了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9771664520, createdName=tony要要要, createdTime=Sat Dec 17 21:03:26 CST 2016, time=2016-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=163219, encodeId=b523163219a5, content=学习了不少东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Fri Dec 16 10:16:55 CST 2016, time=2016-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472523, encodeId=fa7b14e2523f6, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Fri Dec 16 08:47:00 CST 2016, time=2016-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=163043, encodeId=600f163043b5, content=北京同胞注意了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Dec 15 14:34:14 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=163002, encodeId=f9ae163002e2, content=环境保护刻不容缓啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161224/IMG585DA5E26B9F44696.jpg, createdBy=565a98798, createdName=susice, createdTime=Thu Dec 15 10:43:21 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162974, encodeId=e4a91629e476, content=污染危害大, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62d381629, createdName=yafeiliutjh, createdTime=Thu Dec 15 09:01:47 CST 2016, time=2016-12-15, status=1, ipAttribution=)]
    2016-12-18 虈亣靌

    谢谢分享,学习了

    0

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    2016-12-17 tony要要要

    这个影响可就大了

    0

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    2016-12-16 圣艮山

    学习了不少东西

    0

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    2016-12-15 1e10c84am36(暂无匿称)

    北京同胞注意了

    0

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    2016-12-15 susice

    环境保护刻不容缓啊

    0

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    2016-12-15 yafeiliutjh

    污染危害大

    0

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