Diabetes Care:吸烟与2型糖尿病长期风险研究(欧洲人群EPIC-InterAct研究)

2014-12-16 佚名 医学论坛网

研究者对吸烟和2型糖尿病发生之间的关系进行了研究,对于大量的潜在混合因素进行分析,并探讨了潜在的效应修饰和中介因素。研究表明,与不吸烟的男性和女性相比,曾经吸烟和目前吸烟是2型糖尿病的发生相关的高风险因素,其独立于教育水平、体力活动、饮酒、饮食。因此,吸烟可作为2型糖尿病的一个危险因素,应鼓励戒烟预防糖尿病。本研究结果发表于最新一期《糖尿病治疗》上(Diabetes Care December 2

研究者对吸烟和2型糖尿病发生之间的关系进行了研究,对于大量的潜在混合因素进行分析,并探讨了潜在的效应修饰和中介因素。研究表明,与不吸烟的男性和女性相比,曾经吸烟和目前吸烟是2型糖尿病的发生相关的高风险因素,其独立于教育水平、体力活动、饮酒、饮食。因此,吸烟可作为2型糖尿病的一个危险因素,应鼓励戒烟预防糖尿病。本研究结果发表于最新一期《糖尿病治疗》上(Diabetes Care December 2014 vol.37 no.12 3164-3171)。

欧洲癌症与营养前瞻性调查(EPIC- InterAct)研究是一项在八个欧洲国家进行的前瞻性队列研究,其中包括12403例2型糖尿病事件和随机亚队列组患者 16835例。排除丢失数据的人群后,研究纳入10327例事件和13863例患者。研究以从不吸烟者作为对照组,以吸烟状况作为分组(分为从不吸烟、曾经吸烟、目前吸烟)。研究者采用特定国家Prentice加权COX回归模型和随机效应荟萃分析估计2型糖尿病的危险比(HRs)。

在男性 2型糖尿病患者中,曾经吸烟者和当前吸烟者的HRS[95% CI]分别为1.40(1.26,1.55)和1.43(1.27,1.61),这些结果独立于年龄、教育、体育活动、饮用酒精和咖啡、食用肉类等因素。在女性中这种关联性较弱,曾经吸烟者和当前吸烟者的HRS[95% CI]分别为1.18(1.07,1.30)和1.13(1.03,1.25)。研究的一些证据表明BMI为效应修饰因素,与肥胖男性相比,体重正常男性其相关性略强。

原始出处:
InterAct Consortium, Spijkerman AM, van der A DL, Nilsson PM, et.al Smoking and Long-Term Risk of Type 2 Diabetes: The EPIC-InterAct Study in European Populations.Diabetes Care. 2014 Dec;37(12):3164-71. doi: 10.2337/dc14-1020. Epub 2014 Oct 21.




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    2015-04-11 x35042875

    他们的研究数据表明增加肠道中肠促胰素分泌细胞的数目,有可能成为改善血糖代谢的新型治疗方案。

    0

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  7. 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createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Feb 11 17:00:00 CST 2015, time=2015-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20460, encodeId=116b2046047, content=他们的研究数据表明增加肠道中肠促胰素分泌细胞的数目,有可能成为改善血糖代谢的新型治疗方案。, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 22:57:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901259, encodeId=10bf190125979, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Mon Aug 03 22:00:00 CST 2015, time=2015-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055589, encodeId=eb41205558982, content=<a href='/topic/show?id=734110089320' target=_blank style='color:#2F92EE;'>#风险研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100893, encryptionId=734110089320, topicName=风险研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Wed Jun 10 15:00:00 CST 2015, time=2015-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738769, encodeId=a6d41e387693d, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Sun Jun 21 18:00:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13330, encodeId=eeaf1333094, content=与不吸烟的男性和女性相比,曾经吸烟和目前吸烟是2型糖尿病的发生相关的高风险因素,其独立于教育水平、体力活动、饮酒、饮食。因此,吸烟可作为2型糖尿病的一个危险因素,应鼓励戒烟预防糖尿病。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723f1608660, createdName=fengjie741, createdTime=Sun Dec 21 18:06:00 CST 2014, time=2014-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13268, encodeId=879c132681e, content=该研究发现肝脏miR-378作为胰岛素信号通路的一个重要制动因子,通过影响肝脏胰岛素信号通路基础活性,调控葡萄糖以及脂质代谢的动态平衡。, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=870092288, createdName=rosa00tong, createdTime=Fri Dec 19 06:48:00 CST 2014, time=2014-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338935, encodeId=9d1713389351c, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Thu Dec 18 08:00:00 CST 2014, time=2014-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401323, encodeId=71531401323a9, content=<a href='/topic/show?id=80e89e0479a' target=_blank style='color:#2F92EE;'>#长期风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97047, encryptionId=80e89e0479a, topicName=长期风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Thu Dec 18 08:00:00 CST 2014, time=2014-12-18, status=1, ipAttribution=)]
    2014-12-21 fengjie741

    与不吸烟的男性和女性相比,曾经吸烟和目前吸烟是2型糖尿病的发生相关的高风险因素,其独立于教育水平、体力活动、饮酒、饮食。因此,吸烟可作为2型糖尿病的一个危险因素,应鼓励戒烟预防糖尿病。

    0

  8. 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createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Feb 11 17:00:00 CST 2015, time=2015-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20460, encodeId=116b2046047, content=他们的研究数据表明增加肠道中肠促胰素分泌细胞的数目,有可能成为改善血糖代谢的新型治疗方案。, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 22:57:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901259, encodeId=10bf190125979, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, 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channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Sun Jun 21 18:00:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13330, encodeId=eeaf1333094, content=与不吸烟的男性和女性相比,曾经吸烟和目前吸烟是2型糖尿病的发生相关的高风险因素,其独立于教育水平、体力活动、饮酒、饮食。因此,吸烟可作为2型糖尿病的一个危险因素,应鼓励戒烟预防糖尿病。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723f1608660, createdName=fengjie741, createdTime=Sun Dec 21 18:06:00 CST 2014, time=2014-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13268, encodeId=879c132681e, content=该研究发现肝脏miR-378作为胰岛素信号通路的一个重要制动因子,通过影响肝脏胰岛素信号通路基础活性,调控葡萄糖以及脂质代谢的动态平衡。, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=870092288, createdName=rosa00tong, createdTime=Fri Dec 19 06:48:00 CST 2014, time=2014-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338935, encodeId=9d1713389351c, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Thu Dec 18 08:00:00 CST 2014, time=2014-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401323, encodeId=71531401323a9, content=<a href='/topic/show?id=80e89e0479a' target=_blank style='color:#2F92EE;'>#长期风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97047, encryptionId=80e89e0479a, topicName=长期风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Thu Dec 18 08:00:00 CST 2014, time=2014-12-18, status=1, ipAttribution=)]
    2014-12-19 rosa00tong

    该研究发现肝脏miR-378作为胰岛素信号通路的一个重要制动因子,通过影响肝脏胰岛素信号通路基础活性,调控葡萄糖以及脂质代谢的动态平衡。

    0

  9. 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channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Sun Jun 21 18:00:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13330, encodeId=eeaf1333094, content=与不吸烟的男性和女性相比,曾经吸烟和目前吸烟是2型糖尿病的发生相关的高风险因素,其独立于教育水平、体力活动、饮酒、饮食。因此,吸烟可作为2型糖尿病的一个危险因素,应鼓励戒烟预防糖尿病。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723f1608660, createdName=fengjie741, createdTime=Sun Dec 21 18:06:00 CST 2014, time=2014-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13268, encodeId=879c132681e, content=该研究发现肝脏miR-378作为胰岛素信号通路的一个重要制动因子,通过影响肝脏胰岛素信号通路基础活性,调控葡萄糖以及脂质代谢的动态平衡。, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=870092288, createdName=rosa00tong, createdTime=Fri Dec 19 06:48:00 CST 2014, time=2014-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338935, encodeId=9d1713389351c, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, 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  10. 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