Cell Metabolism:减肥术有助于减小大脑对糖的渴求

2015-11-21 MedSci MedSci原创

Cell Metabolism:减肥术有助于减小大脑对糖的渴求胃旁路术已在很多肥胖患者中成功实施,并取得了良好的效果。现在,发表于Cell Metabolism的一项新的研究揭示了减肥术减小大脑对糖渴求的机制。

胃旁路术已在很多肥胖患者中成功实施,并取得了良好的效果。现在,发表于Cell Metabolism的一项新的研究揭示了减肥术减小大脑对糖渴求的机制。

研究报告显示,80%以上的减肥术可取得成功,但是目前为止其取得成功的确切途径尚未可知。患者接受减肥术后对适中种类的喜爱也发生了改变,但是导致此变化的机制仍存在争议。

多巴胺和糖的吸引力

既往研究显示,热量的摄入,部分是由背侧纹状体中的多巴胺所介导的。此多巴胺系统对胃肠道中的糖十分敏感。

由于恋上了糖的甜味,尽管胃中充满了甜液,但是老鼠还是会不断地舔糖水。该违反直觉的行为被认为是由十二指肠糖受体激活介导所致,通过激活在背侧纹状体多巴胺通路,创造一个令人上瘾的恶性循环。

背侧纹状体可协调机体的运动,但这并不是它的唯一功能。现代研究发现背侧纹状体也参与决策的制定。具体而言,通过结合的动机和情感信息背侧纹状体可选择并发起行动。

实验性减肥手术

该研究中,在小鼠体内实施了复杂的减肥手术,与Roux-en-Y胃旁路手术相似。

接受此手术的小鼠胃中还充满了甜水,糖对此小鼠的吸引力显著下降。

研究人员推测,减肥术减少了背侧纹状体中糖诱导的多巴胺的释放,从本质上减少糖的奖赏效应。

为了进一步证明这种关系,研究人员使用光遗传学证实其研究结果。

光遗传学

光遗传学涉及到修饰表达光敏感的离子通道的神经元,科学家们将一组预定的神经元关掉或开启而不需要插入电极。

修改后的小鼠多巴胺神经电路处于持续激活状态,这种奖赏中心的重新激活有效地抑制了手术引起的变化,小鼠再次对糖产生了渴求。

Araujo博士评论道:

“我们的研究结果为纹状体多巴胺信号和减肥干预的结果之间的因果联系提供了第一手证据。但是,我们并不想给人们这样的印象:我们已经了解减肥手术发挥作用的机制。在这一领域仍需要更多的研究。”

研究人员计划通过调查当前可用的四种减肥手术的所有类似效果以扩展研究。Araujo博士补充道,长期的目标是找到不需要通过手术的方法来解决肥胖和糖尿病进展的方案。

原始出处:

Weight-loss surgery reduces brain's sugar addiction. MNT, 20 November 2015.

Wenfei Han et al., Striatal dopamine links gastrointestinal rerouting to altered sweet appetite, Cell Metabolism, doi: http://dx.doi.org/10.1016/j.cmet.2015.10.009, published online 19 November 2015.

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    2016-12-09 MyQueen

    额,这个……好神奇

    0

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    2016-02-10 guojianrong
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  4. 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GetPortalCommentsPageByObjectIdResponse(id=1869251, encodeId=9657186925132, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Sep 27 10:03:00 CST 2016, time=2016-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102864, encodeId=785710286461, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Aug 24 10:17:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102865, encodeId=a98d102865b0, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Aug 24 10:17:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1675621, encodeId=3e7716e562126, content=<a href='/topic/show?id=a678312e289' target=_blank style='color:#2F92EE;'>#减肥术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31272, encryptionId=a678312e289, topicName=减肥术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ee227270207, createdName=kksonne, createdTime=Thu Apr 14 05:03:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959507, encodeId=9330195950e50, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Jan 21 03:03:00 CST 2016, time=2016-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895850, encodeId=604018958503a, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Dec 07 09:03:00 CST 2015, time=2015-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50655, encodeId=18135065599, content=一直想减没实际行动, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Dec 30 22:29:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44472, encodeId=76c9444e2bd, content=一直在减肥哎, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151119/IMG564D22F85A3BB6344.jpg, createdBy=750e1664472, createdName=De_dzw, createdTime=Wed Dec 02 22:06:00 CST 2015, time=2015-12-02, status=1, ipAttribution=)]
    2016-08-24 doctorJiangchao

    继续学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=161514, encodeId=a615161514c1, content=额,这个……好神奇, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29ab1719082, createdName=MyQueen, createdTime=Fri Dec 09 19:50:56 CST 2016, time=2016-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887476, encodeId=e1a4188e47655, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Feb 10 01:03:00 CST 2016, time=2016-02-10, status=1, ipAttribution=), 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encryptionId=a678312e289, topicName=减肥术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ee227270207, createdName=kksonne, createdTime=Thu Apr 14 05:03:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959507, encodeId=9330195950e50, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Jan 21 03:03:00 CST 2016, time=2016-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895850, encodeId=604018958503a, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Dec 07 09:03:00 CST 2015, time=2015-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50655, encodeId=18135065599, content=一直想减没实际行动, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Dec 30 22:29:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44472, encodeId=76c9444e2bd, content=一直在减肥哎, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151119/IMG564D22F85A3BB6344.jpg, createdBy=750e1664472, createdName=De_dzw, createdTime=Wed Dec 02 22:06:00 CST 2015, time=2015-12-02, status=1, ipAttribution=)]
    2016-08-24 doctorJiangchao

    继续关注

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=161514, encodeId=a615161514c1, content=额,这个……好神奇, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29ab1719082, createdName=MyQueen, createdTime=Fri Dec 09 19:50:56 CST 2016, time=2016-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887476, encodeId=e1a4188e47655, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Feb 10 01:03:00 CST 2016, time=2016-02-10, status=1, ipAttribution=), 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encryptionId=a678312e289, topicName=减肥术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ee227270207, createdName=kksonne, createdTime=Thu Apr 14 05:03:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959507, encodeId=9330195950e50, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Jan 21 03:03:00 CST 2016, time=2016-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895850, encodeId=604018958503a, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Dec 07 09:03:00 CST 2015, time=2015-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50655, encodeId=18135065599, content=一直想减没实际行动, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Dec 30 22:29:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44472, encodeId=76c9444e2bd, content=一直在减肥哎, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151119/IMG564D22F85A3BB6344.jpg, createdBy=750e1664472, createdName=De_dzw, createdTime=Wed Dec 02 22:06:00 CST 2015, time=2015-12-02, status=1, ipAttribution=)]
    2016-04-14 kksonne
  7. [GetPortalCommentsPageByObjectIdResponse(id=161514, encodeId=a615161514c1, content=额,这个……好神奇, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29ab1719082, createdName=MyQueen, createdTime=Fri Dec 09 19:50:56 CST 2016, time=2016-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887476, encodeId=e1a4188e47655, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Feb 10 01:03:00 CST 2016, time=2016-02-10, status=1, ipAttribution=), 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encryptionId=a678312e289, topicName=减肥术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ee227270207, createdName=kksonne, createdTime=Thu Apr 14 05:03:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959507, encodeId=9330195950e50, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Jan 21 03:03:00 CST 2016, time=2016-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895850, encodeId=604018958503a, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Dec 07 09:03:00 CST 2015, time=2015-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50655, encodeId=18135065599, content=一直想减没实际行动, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Dec 30 22:29:00 CST 2015, time=2015-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44472, encodeId=76c9444e2bd, content=一直在减肥哎, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151119/IMG564D22F85A3BB6344.jpg, createdBy=750e1664472, createdName=De_dzw, createdTime=Wed Dec 02 22:06:00 CST 2015, time=2015-12-02, status=1, ipAttribution=)]
    2016-01-21 维他命
  8. 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    2015-12-07 一闲
  9. 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    2015-12-30 xyfg98

    一直想减没实际行动

    0

  10. 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    2015-12-02 De_dzw

    一直在减肥哎

    0

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