Clin Nutr:吃大豆对慢性肾脏疾病患者的影响

2016-02-22 Seven L 译 MedSci原创

研究者检索了Medline、Embase等数据库,进行了一项荟萃分析,评估大豆蛋白摄入量对慢性肾脏疾病(CKD)患者的影响。最终有12项研究纳入荟萃分析,涉及280名患者。荟萃分析数据显示,血液透析前亚组人群中,大豆膳食可现在降低血清肌酐(MD -0.05 mg/dL (95% CI: -0.10, -0.00 mg/dL; P = 0.04))、血清磷( -0.13 mg/dL (95% CI:

研究者检索了Medline、Embase等数据库,进行了一项荟萃分析,评估大豆蛋白摄入量对慢性肾脏疾病(CKD)患者的影响。

最终有12项研究纳入荟萃分析,涉及280名患者。荟萃分析数据显示,血液透析前亚组人群中,大豆膳食可现在降低血清肌酐(MD -0.05 mg/dL (95% CI: -0.10, -0.00 mg/dL; P = 0.04))、血清磷( -0.13 mg/dL (95% CI: -0.26, -0.01 mg/dL; P = 0.04) )、CRP(-0.98 mg/L (95% CI: -1.25, -0.71 mg/L; P < 0.00001))和蛋白尿(-0.13 mg/d (95% CI: -0.18, -0.08 mg/d; P < 0.00001))。对于透析组,研究者没有发现血清磷和CRP的两组间差异。将透析前患者和透析后患者作为一个整体进行分析,研究者发现,大豆膳食组与对照组相比,可现在降低血尿素氮(BUN)水平(-0.37 mg/dL (95% CI: -6.03, -0.11 mg/dL; P = 0.04))。但是研究者没有发现两组间肌酐清除率、肾小球滤过率、血清白蛋白、体重和BMI的差异。

荟萃分析结果表明,含有异黄酮的大豆蛋白摄入可显著降低血液透析前患者的血清肌酐、血清磷、CRP和蛋白尿,但是不能改善肌酐清除率和肾小球滤过率。此外大豆蛋白摄入量可以维持透析病人的营养状况,尽管不能改善CRP、BUN和血清磷。未来还需要进行大型、长期的RCTs以验证大豆蛋白摄入对CKD患者的影响。

原始出处:

Jing Z, Wei-Jie Y,et al.Effects of soy protein containing isoflavones in patients with chronic kidney disease: A systematic review and meta-analysis.Clin Nutr. 2016 Feb;35(1):117-24. doi: 10.1016/j.clnu.2015.03.012.

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    2016-02-23 青争

    我是来看结论的

    0

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    2016-02-23 青争

    有好处就行

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1798953, encodeId=c1a11e98953d2, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sat Oct 22 13:19:00 CST 2016, time=2016-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616069, encodeId=84901616069c7, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Wed Feb 24 08:19:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65294, encodeId=4278652942d, content=我是来看结论的, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160216/IMG56C28FA0D251A3302.jpg, createdBy=1c9c1687290, createdName=青争, createdTime=Tue Feb 23 21:13:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65295, encodeId=34106529543, content=有好处就行, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160216/IMG56C28FA0D251A3302.jpg, createdBy=1c9c1687290, createdName=青争, createdTime=Tue Feb 23 21:13:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65270, encodeId=a8e6652e01d, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Feb 23 14:30:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65218, encodeId=d98d65218d1, content=!!k学, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33591686340, createdName=1de48a27m96(暂无匿称), createdTime=Tue Feb 23 07:35:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65219, encodeId=9ec365219c0, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33591686340, createdName=1de48a27m96(暂无匿称), createdTime=Tue Feb 23 07:35:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65202, encodeId=a72865202a4, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Mon Feb 22 23:30:00 CST 2016, time=2016-02-22, status=1, ipAttribution=)]
    2016-02-23 忠诚向上

    好好学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1798953, encodeId=c1a11e98953d2, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sat Oct 22 13:19:00 CST 2016, time=2016-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616069, encodeId=84901616069c7, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Wed Feb 24 08:19:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65294, encodeId=4278652942d, content=我是来看结论的, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160216/IMG56C28FA0D251A3302.jpg, createdBy=1c9c1687290, createdName=青争, createdTime=Tue Feb 23 21:13:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65295, encodeId=34106529543, content=有好处就行, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160216/IMG56C28FA0D251A3302.jpg, createdBy=1c9c1687290, createdName=青争, createdTime=Tue Feb 23 21:13:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65270, encodeId=a8e6652e01d, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Feb 23 14:30:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65218, encodeId=d98d65218d1, content=!!k学, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33591686340, createdName=1de48a27m96(暂无匿称), createdTime=Tue Feb 23 07:35:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65219, encodeId=9ec365219c0, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33591686340, createdName=1de48a27m96(暂无匿称), createdTime=Tue Feb 23 07:35:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65202, encodeId=a72865202a4, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Mon Feb 22 23:30:00 CST 2016, time=2016-02-22, status=1, ipAttribution=)]
    2016-02-23 1de48a27m96(暂无匿称)

    !!k学

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1798953, encodeId=c1a11e98953d2, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sat Oct 22 13:19:00 CST 2016, time=2016-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616069, encodeId=84901616069c7, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Wed Feb 24 08:19:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65294, encodeId=4278652942d, content=我是来看结论的, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160216/IMG56C28FA0D251A3302.jpg, createdBy=1c9c1687290, createdName=青争, createdTime=Tue Feb 23 21:13:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65295, encodeId=34106529543, content=有好处就行, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160216/IMG56C28FA0D251A3302.jpg, createdBy=1c9c1687290, createdName=青争, createdTime=Tue Feb 23 21:13:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65270, encodeId=a8e6652e01d, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Feb 23 14:30:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65218, encodeId=d98d65218d1, content=!!k学, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33591686340, createdName=1de48a27m96(暂无匿称), createdTime=Tue Feb 23 07:35:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65219, encodeId=9ec365219c0, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33591686340, createdName=1de48a27m96(暂无匿称), createdTime=Tue Feb 23 07:35:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65202, encodeId=a72865202a4, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Mon Feb 22 23:30:00 CST 2016, time=2016-02-22, status=1, ipAttribution=)]
    2016-02-23 1de48a27m96(暂无匿称)

    有用

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1798953, encodeId=c1a11e98953d2, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sat Oct 22 13:19:00 CST 2016, time=2016-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616069, encodeId=84901616069c7, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Wed Feb 24 08:19:00 CST 2016, time=2016-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65294, encodeId=4278652942d, content=我是来看结论的, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160216/IMG56C28FA0D251A3302.jpg, createdBy=1c9c1687290, createdName=青争, createdTime=Tue Feb 23 21:13:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65295, encodeId=34106529543, content=有好处就行, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160216/IMG56C28FA0D251A3302.jpg, createdBy=1c9c1687290, createdName=青争, createdTime=Tue Feb 23 21:13:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65270, encodeId=a8e6652e01d, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Feb 23 14:30:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65218, encodeId=d98d65218d1, content=!!k学, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33591686340, createdName=1de48a27m96(暂无匿称), createdTime=Tue Feb 23 07:35:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65219, encodeId=9ec365219c0, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33591686340, createdName=1de48a27m96(暂无匿称), createdTime=Tue Feb 23 07:35:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=65202, encodeId=a72865202a4, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Mon Feb 22 23:30:00 CST 2016, time=2016-02-22, status=1, ipAttribution=)]
    2016-02-22 sanshengshi

    0

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