JAMA Neurol:心脏骤停幸存患儿神经系统损伤研究

2018-09-18 zhangfan MedSci原创

研究发现心脏骤停昏迷的儿童,在接受适当的抢救幸存后,约71.2%患儿预后良好,但预后良好人群中约25%存在认知损伤,特别是年龄较大儿童认知损伤风险增加

心脏骤停(CA)后幸存患儿,对其神经系统损伤情况的研究尚不充分。近日研究人员考察了2个队列(THAPCA-IH和THAPCA-OH队列)CA幸存患儿的神经心理学结果

222名,1-18岁的CA患儿参与研究,患儿接受2分钟以上的胸部按压后仍处于昏迷状态,循环恢复后需机械通气,并接受了NICU低温治疗。研究的主要终点为1年后VABS-II神经行为功能评估。

160名患儿完成评估,平均年龄2.5岁。114名患儿(71.2%)归类为预后良好(VABS-II≥70),其神经损伤7-61%。研究发现VABS-II评估存在一定局限性--对于低年龄患儿其认知功能与VABS-II得分之间的相关性显著,但年龄稍大患儿的相关性降低。111名患儿VABS-II评估显示预后良好,但其中25.2%存在认知损伤,而35名年龄较大的儿童中,30人(85.7%)有选择性神经心理缺陷。

研究发现心脏骤停昏迷的儿童,在接受适当的抢救幸存后,约71.2%患儿预后良好,但预后良好人群中约25%存在认知损伤,特别是年龄较大儿童认知损伤风险增加。

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    2019-05-01 yinhl1978
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    2018-09-25 wxl882001

    学习一下

    0

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    2018-09-20 一一一多

    重要的研究结论

    0

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