Diabetes Care:2型糖尿病频繁应用他汀可能加速冠脉钙化

2012-08-21 高晓方 医学论坛网

    美国学者的一项研究表明,在伴有严重动脉粥样硬化的2型糖尿病患者中,更为频繁的应用他汀类与冠脉钙化加速具有相关性。论文于2012年8月8日在线发表于《糖尿病护理》(Diabetes Care)杂志。   此项研究共纳入197例2型糖尿病受试者,并依据他汀类应用频率评估了冠脉钙化(CAC)和腹主动脉钙化(AAC)进展程度。   结果显示,对基线CAC

    美国学者的一项研究表明,在伴有严重动脉粥样硬化的2型糖尿病患者中,更为频繁的应用他汀类与冠脉钙化加速具有相关性。论文于2012年8月8日在线发表于《糖尿病护理》(Diabetes Care)杂志。

  此项研究共纳入197例2型糖尿病受试者,并依据他汀类应用频率评估了冠脉钙化(CAC)和腹主动脉钙化(AAC)进展程度。

  结果显示,对基线CAC和其他混淆因素进行校正之后,他汀类应用频率较高受试者的CAC进展程度显著高于应用频率较低者(P<0.01)。他汀类应用频率较高者的ACA进展程度一般较高,但不具有统计学意义。然而,在最初未应用他汀类的亚组受试者中,他汀类应用频率较高者的CAC和AAC进展程度均显著升高。

  链接:Aramesh Saremi,Gideon Bahn,Peter D. Reaven, Progression of Vascular Calcification Is Increased With Statin Use in the Veterans Affairs Diabetes Trial (VADT).Diabetes Care



    

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