Circulation:青少年和年轻成人癌症幸存者心脏病风险分析

2016-11-08 xing.T MedSci原创

这项研究调查了超过200000名癌症幸存者的结果显示,癌症诊断的年龄在确定随后的心脏死亡风险是至关重要的。

青少年和年轻成人癌症幸存者一直是研究的重点。然而,很少有关于他们的长期健康风险的研究,特别是心脏病方面。使用心脏毒性药物治疗的癌症患者,其心脏病发病率明显增加。近日,心血管领域权威杂志Circulation上发表了一篇来自英国伯明翰大学应用健康研究所儿童癌症幸存者研究中心的Katherine E. Henson医生及其团队的研究文章,旨在评估青少年和年轻的成年癌症幸存者的心血管疾病死亡率。 

青少年和年轻的成年癌症幸存者研究队列包括从1971年至2006年期间在英格兰和威尔士地区,200,945名年龄在15岁至39岁期间诊断为癌症后5年的幸存者,研究者对他们随访至2014年,计算标准化死亡率、绝对风险和累积风险。 

研究者发现共有2060名幸存者死于心脏病。结合所有的癌症种类,年龄段位于1519岁的癌症患者全部心脏疾病的标准化死亡率(4.295%可信区间为3.4-5.2)最高,而年龄在35岁至39岁的癌症患者心脏疾病的标准化死亡率降低到1.295%置信区间为1.1-1.3)(P趋势<0.0001)。同时,研究者在缺血性心脏病、心脏瓣膜病和心肌病方面都观察到了类似的标准化死亡率的绝对风险。在霍奇金淋巴瘤、急性髓系白血病、除了膀胱癌以外的其他泌尿生殖系统癌症、非霍奇金淋巴瘤、肺癌、除急性髓细胞白血病外的其他白血病、中枢神经系统肿瘤、宫颈癌、乳腺癌幸存者中,他们因心脏病死亡的人数比一般人群分别高出了3.82.72.01.71.71.61.41.31.2倍。在60岁以上的霍奇金淋巴瘤的幸存者中,将近30%的人死于心脏病。 

这项研究调查了超过200,000名癌症幸存者的结果显示,癌症确诊的年龄在确定随后的心脏死亡风险方面是至关重要的。 

原始出处: 

Katherine E. Henson, et al. Cardiac Mortality Among 200,000 Five-Year Survivors of Cancer Diagnosed Aged 15-39 Years: The Teenage and Young Adult Cancer Survivor Study.  Circulation. November 7, 2016. 

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    2016-11-17 ylzr123

    癌症确诊的年龄在确定随后的心脏死亡风险方面是至关重要的。

    0

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    2016-11-10 laoli

    学习了!谢谢分享!

    0

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