AHA2012年会:心肺功能下降使AMI和全因死亡风险加倍

2012-11-09 欧柏青 医学论坛网

  芬兰的一项研究表明,在头10年随访期间心肺功能下降超过15%的男性,在第二个10年发生急性心肌梗死(AMI)以及全因死亡的风险加倍。这项名为“库奥皮奥地区缺血性心脏病危险因素研究(Kuopio Ischemic Heart Disease Risk Factor Study)10年随访”的研究结果公布于11月4日的美国心脏学会(AHA)2012科学年会上。   研究纳入了2682名年龄在42

  芬兰的一项研究表明,在头10年随访期间心肺功能下降超过15%的男性,在第二个10年发生急性心肌梗死(AMI)以及全因死亡的风险加倍。这项名为“库奥皮奥地区缺血性心脏病危险因素研究(Kuopio Ischemic Heart Disease Risk Factor Study)10年随访”的研究结果公布于11月4日的美国心脏学会(AHA2012科学年会上。

  研究纳入了2682名年龄在42-60岁的男性,其中绝大多数在基线水平没有心血管疾病,但有一些人有冠心病史。所有研究对象在20世纪80年代后期进行的基线检查均包括运动试验时的呼吸气体分析和心电图。在原来的队列中,585名在11年后接受了重复测试。10年中最大摄氧量VO2max平均下降5.2mL/kg/min(等于1.9MET)。既往研究已经表明人类从20-80岁的年龄段通常每10年心肺功能下降5-15%。

  研究在第二次心肺功能测试后平均随访10.9年。在随访期间,总共有81例受试者发生AMI,92例受试者死亡。

  分析表明,在校正年龄和其它危险因素后,十年间心肺功能下降超过15%的人群发生AMI的分险增加88%,全因死亡风险增加122%。即使把基线的VO2max水平考虑进来其结果仍然具有统计学差异。

  目前指南尚不支持对健康人群常规进行心肺功能测试。不过该研究作者Jari A Laukkanen博士认为,未来在诊所进行更多的运动试验有一定的合理性,因为该试验简单易行,价格低廉且无创。

  他还认为,临床医师通常只注意那些容易治疗的危险因素,比如血脂、体质指数(BMI)、吸烟、血压、糖尿病以及饮酒等等。本研究表明体质水平需要更加重视,研究结果还提醒广大医生,督促病人从事体育锻炼保持体质对于其心血管健康和长寿具有可预见的益处。

  

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    2012-12-18 aids222
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    2012-11-11 zhaohui6731
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