糖尿病

订阅

MedSci主页 / 所有栏目 / 糖尿病

Sci Rep：外泌体miRNAs的变化或可预测1型糖尿病的发生

2017-08-06 MedSci MedSci原创

1型糖尿病外泌体miRNAs
关注

1型糖尿病（T1DM）是自身免疫攻击胰岛素产生ß细胞而导致的慢性高血糖的结果。外泌体是来自细胞的膜状脂质囊泡，富含特异性miRNA，或可为某特定疾病的诊断提供信息。为了评估从外泌体中提取的miRNAs作为T1DM诊断的生物标志物的价值。研究人员利用差速离心分离出血浆中的外泌体，并通过纳米粒子跟踪分析和透射电子显微镜观察证实外泌体的存在。提取出外泌体内的总RNA，然后比较了12个T1DM患者和12个

1型糖尿病（T1DM）是自身免疫攻击胰岛素产生ß细胞而导致的慢性高血糖的结果。外泌体是来自细胞的膜状脂质囊泡，富含特异性miRNA，或可为某特定疾病的诊断提供信息。

为了评估从外泌体中提取的miRNAs作为T1DM诊断的生物标志物的价值。研究人员利用差速离心分离出血浆中的外泌体，并通过纳米粒子跟踪分析和透射电子显微镜观察证实外泌体的存在。提取出外泌体内的总RNA，然后比较了12个T1DM患者和12个对照者miRNA的区别。

结果显示，T1DM患者外泌体中7种miRNA的表达与对照组不同（1个上调，6个下调）。然后通过qRT-PCRFenix在24名T1DM和24名对照者的中进行了验证。结果显示大部分下调的miRNAs参与了T1DM的发生。

总之，该研究结果表明，外泌体miRNAs具有诊断T1DM的潜力，并对T1DM发生的分子机制提供了新的见解。

原始出处：

Marta Garcia-Contreras, Sanket H. Shah, et al., Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes. Sci Rep. 2017; 7: 5998. Published online 2017 Jul 20. doi: 10.1038/s41598-017-05787-y.


版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1930480, encodeId=700e193048034, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Dec 08 02:42:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005428, encodeId=71a22005428d7, content=<a href='/topic/show?id=d09f155461e' target=_blank style='color:#2F92EE;'>#RNAs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15546, encryptionId=d09f155461e, topicName=RNAs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Tue Jul 10 11:42:00 CST 2018, time=2018-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312299, encodeId=15d2131229957, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Tue Aug 08 09:42:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573453, encodeId=85fc15e345388, content=<a href='/topic/show?id=cfa41194855' target=_blank style='color:#2F92EE;'>#miRNAs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11948, encryptionId=cfa41194855, topicName=miRNAs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=303215877043, createdName=30397609, createdTime=Tue Aug 08 09:42:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231077, encodeId=561b2310e763, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Aug 07 11:37:08 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230792, encodeId=7416230e92b4, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Aug 06 18:46:34 CST 2017, time=2017-08-06, status=1, ipAttribution=)]
    2017-12-08 smallant2002

    #miR#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1930480, encodeId=700e193048034, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Dec 08 02:42:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005428, encodeId=71a22005428d7, content=<a href='/topic/show?id=d09f155461e' target=_blank style='color:#2F92EE;'>#RNAs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15546, encryptionId=d09f155461e, topicName=RNAs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Tue Jul 10 11:42:00 CST 2018, time=2018-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312299, encodeId=15d2131229957, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Tue Aug 08 09:42:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573453, encodeId=85fc15e345388, content=<a href='/topic/show?id=cfa41194855' target=_blank style='color:#2F92EE;'>#miRNAs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11948, encryptionId=cfa41194855, topicName=miRNAs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=303215877043, createdName=30397609, createdTime=Tue Aug 08 09:42:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231077, encodeId=561b2310e763, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Aug 07 11:37:08 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230792, encodeId=7416230e92b4, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Aug 06 18:46:34 CST 2017, time=2017-08-06, status=1, ipAttribution=)]
    2018-07-10 dzx0922889

    #RNAs#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1930480, encodeId=700e193048034, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Dec 08 02:42:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005428, encodeId=71a22005428d7, content=<a href='/topic/show?id=d09f155461e' target=_blank style='color:#2F92EE;'>#RNAs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15546, encryptionId=d09f155461e, topicName=RNAs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Tue Jul 10 11:42:00 CST 2018, time=2018-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312299, encodeId=15d2131229957, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Tue Aug 08 09:42:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573453, encodeId=85fc15e345388, content=<a href='/topic/show?id=cfa41194855' target=_blank style='color:#2F92EE;'>#miRNAs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11948, encryptionId=cfa41194855, topicName=miRNAs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=303215877043, createdName=30397609, createdTime=Tue Aug 08 09:42:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231077, encodeId=561b2310e763, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Aug 07 11:37:08 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230792, encodeId=7416230e92b4, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Aug 06 18:46:34 CST 2017, time=2017-08-06, status=1, ipAttribution=)]
    2017-08-08 Homburg

    #miRNA#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1930480, encodeId=700e193048034, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Dec 08 02:42:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005428, encodeId=71a22005428d7, content=<a href='/topic/show?id=d09f155461e' target=_blank style='color:#2F92EE;'>#RNAs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15546, encryptionId=d09f155461e, topicName=RNAs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Tue Jul 10 11:42:00 CST 2018, time=2018-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312299, encodeId=15d2131229957, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Tue Aug 08 09:42:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573453, encodeId=85fc15e345388, content=<a href='/topic/show?id=cfa41194855' target=_blank style='color:#2F92EE;'>#miRNAs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11948, encryptionId=cfa41194855, topicName=miRNAs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=303215877043, createdName=30397609, createdTime=Tue Aug 08 09:42:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231077, encodeId=561b2310e763, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Aug 07 11:37:08 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230792, encodeId=7416230e92b4, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Aug 06 18:46:34 CST 2017, time=2017-08-06, status=1, ipAttribution=)]
    2017-08-08 30397609

    #miRNAs#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1930480, encodeId=700e193048034, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Dec 08 02:42:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005428, encodeId=71a22005428d7, content=<a href='/topic/show?id=d09f155461e' target=_blank style='color:#2F92EE;'>#RNAs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15546, encryptionId=d09f155461e, topicName=RNAs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Tue Jul 10 11:42:00 CST 2018, time=2018-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312299, encodeId=15d2131229957, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Tue Aug 08 09:42:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573453, encodeId=85fc15e345388, content=<a href='/topic/show?id=cfa41194855' target=_blank style='color:#2F92EE;'>#miRNAs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11948, encryptionId=cfa41194855, topicName=miRNAs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=303215877043, createdName=30397609, createdTime=Tue Aug 08 09:42:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231077, encodeId=561b2310e763, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Aug 07 11:37:08 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230792, encodeId=7416230e92b4, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Aug 06 18:46:34 CST 2017, time=2017-08-06, status=1, ipAttribution=)]
    2017-08-07 清风拂面

    谢谢分享，学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1930480, encodeId=700e193048034, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Dec 08 02:42:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005428, encodeId=71a22005428d7, content=<a href='/topic/show?id=d09f155461e' target=_blank style='color:#2F92EE;'>#RNAs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15546, encryptionId=d09f155461e, topicName=RNAs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Tue Jul 10 11:42:00 CST 2018, time=2018-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312299, encodeId=15d2131229957, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Tue Aug 08 09:42:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573453, encodeId=85fc15e345388, content=<a href='/topic/show?id=cfa41194855' target=_blank style='color:#2F92EE;'>#miRNAs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11948, encryptionId=cfa41194855, topicName=miRNAs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=303215877043, createdName=30397609, createdTime=Tue Aug 08 09:42:00 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231077, encodeId=561b2310e763, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Aug 07 11:37:08 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230792, encodeId=7416230e92b4, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Aug 06 18:46:34 CST 2017, time=2017-08-06, status=1, ipAttribution=)]
    2017-08-06 wxl882001

    学习一下

    0

相关资讯

Diabetologia：翻译后修饰的胰岛素抗体作为预测儿童1型糖尿病的新型生物标志物

研究人员已经表明，1型糖尿病中胰岛素的自身免疫可能是由氧化后翻译修饰（oxPTM）诱导的新表皮引起的。对oxPTM-胰岛素（oxPTM-INS-Ab）特异性的抗体存在于大多数新近被诊断为1型糖尿病的个体中，并且比天然胰岛素的自身抗体更为常见。在本研究中，研究人员调查了在1型糖尿病临床发作前是否存在oxPTM-INS-Ab，并评估了oxPTM-INS-Ab作为鉴定儿童1型糖尿病的进展的效果。

Diabetes：HIIT能否减少1型糖尿病患者低血糖后认知障碍的发生？

2017年7月，发表在《Diabetes》的一项由荷兰和英国科学家进行的研究表明，高强度间歇训练（HIIT）降低1型糖尿病患者对后续低血糖的认知。

Nat Med：惊喜！NIH、川大、山大、南大联合发现，遍地都是的甘露糖竟然可以缓解1型糖尿病等自身免疫疾病

一说起食物中的糖，我们首先想到的通常是葡萄糖、果糖和蔗糖等等。这些对于糖尿病患者来说，真的是冤家一般的存在，不过，小编要是跟大家说，有一种“糖”可以抑制1型糖尿病的发展，大家敢不敢信？ 这个神奇的“糖”就是葡萄糖的“异构体姐妹”——D-甘露糖。D-甘露糖天然存在于许多水果中，比如因为“保健”效果被炒得火热的蔓越莓。D-甘露糖在我们血液中的水平还不到葡萄糖的1/5，也没有葡萄糖那么受到重视。不

JCEM：超过50年的1型糖尿病血糖控制获益几何？

之前的研究表明50年或以上的1型糖尿病患者（Medalists），其血糖控制水平与糖尿病并发症无关，除了心血管疾病（CVD），这与之前注册研究的记录相反。

What？抗癌药用于1型糖尿病！

早期研究表明，抑制免疫系统并被批准用于治疗慢性骨髓性白血病和其他一些肿瘤的酪氨酸激酶抑制剂伊马替尼，可能有助于保护新诊断1型糖尿病人群的一些β细胞功能。美国加州大学旧金山分校的Stephen Gitelman教授在最近召开的美国糖尿病协会（ADA）2017科学会议上介绍了来自67名成年人的2年随机临床试验的初步1年发现。

Neurology：ω-3补充剂对1型糖尿病神经病变有何影响？

2017年6月，发表在《Neurology》的一项由加拿大科学家进行的为期12个月的先导试验，考察了ω-3补充剂对1型糖尿病（T1DM）神经病变的影响。