BMC Medicine:女性生殖因素与其健康状况密切相关

2015-11-01 MedSci MedSci原创

发表在BMC Medicine的最新研究结果表明,女性的某些生殖因素可降低女性早期死亡的风险。 生殖功能与女性内分泌系统的变化与调节密切相关。具有生殖功能对女性而言具有十分重要的意义。既往研究表明,个别生殖因素与所有类型的死亡原因或多或少都存在一定的关联,并会增加一些特定疾病的死亡风险。但是,对于生殖因素对女性长期体质和身体健康的影响,研究人员尚未可知。鉴于这些因素彼此之间都有着紧密的联系,研究人

发表在BMC Medicine的最新研究结果表明,女性的某些生殖因素可降低女性早期死亡的风险。

 
生殖功能与女性内分泌系统的变化与调节密切相关。具有生殖功能对女性而言具有十分重要的意义。既往研究表明,个别生殖因素与所有类型的死亡原因或多或少都存在一定的关联,并会增加一些特定疾病的死亡风险。但是,对于生殖因素对女性长期体质和身体健康的影响,研究人员尚未可知。鉴于这些因素彼此之间都有着紧密的联系,研究人员致力于研究女性的一些生殖特征所导致死亡及癌症和心血管疾病等的风险。

伦敦帝国学院的Melissa Merritt及其同事对来自10个国家共计 322972名女士(她们均为EPIC研究的参与人员)进行了研究分析。 

研究初始时,参与者完成与饮食、生活方式、疾病史等相关的调查问卷和访谈。平均随访时间约为12.9年,在此期间有14383人死亡,其中5938人死于癌症,2404人死于循环系统疾病。 

总的来说,研究人员发现,在控制了BMI、吸烟史和运动量等因素后,有过生育史(尤其是在26-30岁生育)、母乳喂养、14岁后开始月经来潮、口服避孕药的人健康状况更佳,罹患癌症或心血管疾病的可能性较小。 

26-30岁生育的女性死亡风险较低,20岁之前或31岁之后生育的女性死亡风险较高;
女性采用母乳喂养也能降低其死亡风险;
15岁后开始月经来潮的女性相比12岁之前月经来潮的女性死亡风险较低;
口服避孕药的女性整体死亡风险适当降低;罹患癌症合心血管疾病的风险也可降低;
生育过宝宝的女性相比无生育史的女性罹患癌症的风险较低。此外,有两个或三个孩子的女性死亡风险较只有一个孩子的女性小。
 
进一步分析发现,有过生育史和母乳喂养的女性患缺血性心脏病的风险降低。 

研究人员认为,生殖因素都与女性体内激素水平的变化有关,这表明激素的作用机制可能会降低女性的死亡风险。当然他们需要进一步的研究来证实这项发现,并明确死亡或患病风险降低的机制。 因此,女性的某些生殖因素对其身体健康有着至关重要的作用。

原始出处:

Reproductive factors may lower women's risk of early death,MNT,30,Oct,2015

Melissa Merritt et al.Reproductive factors and risk of mortality in the European Prospective Investigation into cancer and nutrition; a cohort study,BMC Medicine.30 Oct,2015

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    2016-04-26 jeanqiuqiu
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    2016-05-05 kalseyzl
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