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Nat Commun：重磅级发现！遗传因素或会影响机体的免疫特征表现

2017-01-06 佚名 生物谷

免疫特征
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图片来源：medicalxpress.com 日前，来自伦敦大学国王学院的研究人员通过研究表明，几乎四分之三的免疫性状都会被基因所影响，相关研究刊登于国际杂志Nature Communications上，该研究再次证实了此前研究人员的结论，即遗传会影响机体的免疫系统。 该项研究由英国国家健康研究所生物医学中心等机构提供资助，文章中研究者对来自TwinsUK队列研究中的497对成年女性双胞

图片来源：medicalxpress.com

日前，来自伦敦大学国王学院的研究人员通过研究表明，几乎四分之三的免疫性状都会被基因所影响，相关研究刊登于国际杂志Nature Communications上，该研究再次证实了此前研究人员的结论，即遗传会影响机体的免疫系统。

该项研究由英国国家健康研究所生物医学中心等机构提供资助，文章中研究者对来自TwinsUK队列研究中的497对成年女性双胞胎机体中的2.3万种免疫特征进行分析研究，他们发现，机体适应性的免疫特征大部分都会受到遗传因素的影响，当机体暴露于特殊的病原体（比如水痘）中时就会产生这些复杂的免疫特征。

同时研究者还强调了环境影响的重要性，比如饮食等，其能够塑造成年机体的先天性免疫力，本文研究能够帮助研究人员改善对机体免疫系统以及免疫系统同环境因子相互作用的理解，同时还能够为科学家们深入探究治疗多种疾病的新型疗法提供研究思路，包括风湿性关节炎和银屑病等。

研究者Massimo Mangino说道，我们进行遗传分析往往会发现一些意想不到的结果，在自然状态下非常复杂的先天性免疫反应似乎也会被基因组中的突变所影响，而这是我们之前不曾想到的。相比较而言，先天性免疫反应的改变更多地源于环境差异的产生，本文研究结果对于我们治疗一系列自身免疫系统或许非常重要。

本文研究揭示了机体大多数免疫反应的起源以及被调节的分子机制，这意味着我们很有可能会以一种特殊的个体化方式对诸如病毒感染在内的多种感染产生反应，当然这对于后期科学家们开发新型个体化疗法具有重要的意义。

原始出处

Massimo Mangino, Mario Roederer, Margaret H. Beddall, Frank O. Nestle & Tim D. Spector.Innate and adaptive immune traits are differentially affected by genetic and environmental factors.Nat Commun.2016

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    2017-05-24 liye789132251

    #Nat#

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