盘点:低出生体重儿2016重要研究进展

2016-09-17 MedSci MedSci原创

低出生体重儿是指出生体重小于2500g的婴儿。胎儿阶段多种原因可导致胎儿发育迟缓,在出生时体重过低 。这样的新生儿皮下脂肪少,保温能力差,呼吸机能和代谢机能都比较弱,容易感染疾病。死亡率比体重正常的新生儿要高得多,其智力发展也会受到一定的影响。这里小M整理了2016年以来关于低出生体重儿的重要研究进展与大家分享。【1】孕前高血压是否与低出生体重和小于胎龄儿风险有关最近心血管领域权威杂志《hyp

低出生体重儿是指出生体重小于2500g的婴儿。胎儿阶段多种原因可导致胎儿发育迟缓,在出生时体重过低 。这样的新生儿皮下脂肪少,保温能力差,呼吸机能和代谢机能都比较弱,容易感染疾病。死亡率比体重正常的新生儿要高得多,其智力发展也会受到一定的影响。这里小M整理了2016年以来关于低出生体重儿的重要研究进展与大家分享。

【1】孕前高血压是否与低出生体重和小于胎龄儿风险有关

最近心血管领域权威杂志《hypertension》刊登了北京大学医学部公共卫生学院任爱国教授及其团队的研究成果,该研究旨在揭示中国女性孕前血压高与低出生体重(LBW)和小于胎龄儿(SGA)的关系。

研究从中国–美国合作有关预防神经管缺陷的队列研究中提取数据。研究者纳入了我国南部7省的43718例28−45周孕龄的单胎活产妇女。在怀孕前,所有研究对象由受过培训的医务人员测量血压,并登记其他与健康相关的信息。

在研究人群中发生孕前高血压的几率为4.62%(2019/43718),LBW和SGA的发生率在孕前高血压组分别为2.33%和5.05%;在孕前非高血压组为2.01%、5.68%。与孕前非高血压组比较,孕前高血压组并没有明显增加LBW或SGA的整体风险。即使参与者以正常血压作为参考,调整后的前高血压女性生产SGA的风险比为1.13。

最终研究结果并不支持孕前高血压患者或血压较高与LBW或SGA的风险增加之间存在关联。(文章详见——Hypertension:孕前高血压与低出生体重和小于胎龄儿风险有关吗?



【2】孕期出现抑郁症增加新生儿低出生体重风险

一项新的荟萃分析结果显示,孕期抑郁增加婴儿早产和低出生体重的风险。研究人员采用详细的文献搜索方式收集各种研究资料,包括探究抑郁症与非抑郁症孕妇分娩的新生儿不良结果的相关随机或非随机对照研究。研究人员使用临床访谈、筛查工具以及量表等方式评估孕妇是否患有抑郁症。关注的主要结果是妊娠32或37周前分娩的早产儿、小于胎龄儿、大于胎龄儿、低出生体重儿、进入ICU治疗的新生儿数量。这项分析包括23个研究,没有研究报道32周前分娩的新生儿或大于胎龄儿,仅有一项研究报道小于胎龄儿,有2项研究指出有新生儿进入ICU治疗。

结果发现,与没有抑郁症的孕妇相比,那些未经治疗的抑郁症孕妇在孕37周前分娩的可能性增加,新生儿低出生风险也明显增加。使用临床诊断或访谈等方式与量表评估的研究没有差异。

至于抑郁如何导致新生儿早产或低体重,Jarde博士指出,这可能不是抑郁本身的原因,而是吸烟、焦虑、和社会经济地位低下等因素所致。未采取治疗措施的抑郁症孕妇应密切关注其抑郁程度和心理健康状况,同时监护胎儿的生命体征。(文章详见——JAMA Psychiatry:孕期出现抑郁症增加新生儿低出生体重风险


【3】对于极低出生体重儿,严重贫血增加了坏死性小肠结肠炎的风险

关于红细胞(RBC)输血和贫血而引起坏死性小肠结肠炎(NEC)的数据是相互矛盾的。这些关联还没有前瞻性评估,计算那些反复,随时间变化的风险。

在一项二级,前瞻性,多中心观察队列研究中,极低出生体重儿(VLBW,≤1500g),在出生后5天,被送到了亚特兰大3个III级新生儿重症监护病房。婴幼儿接受了直到90天的随访,出院,转移到一家非研究附属医院,或死亡(以先发生哪种情况为准)。

最终600名VLBW婴儿被纳入研究,598名被进行了评价。44(7.4%)名婴儿患有NEC。32(5.4%)名婴儿死亡。53%的婴儿(319名)共接受1430次RBC输血。 在第8周所有的RBC输血暴露的婴儿中NEC未经调整的累积发生率为9.9% vs 未经RBC输血暴露的为4.6%。在多变量分析中,在给定的一周中RBC输血与NEC率没有显著相关。基于血红蛋白的4565纵向测量评估,与那些没有严重贫血的VLBW相比,在给定一周中,有严重贫血的VLBWNEC率显著增加。

在VLBW婴儿中,严重贫血,但不进行红细胞输血,增加了NEC的风险。还需要进一步的研究来评估是否预防严重贫血比减少红细胞输血更重要。(文章详见——JAMA:对于极低出生体重儿,严重贫血增加了坏死性小肠结肠炎的风险



【4】JAMA Pediatr:血小板输注并不能降低极低出生体重儿的脑室出血风险

血小板减少和脑室出血(IVH)是极低出生体重儿(VLBW)常见的症状。调查结果表明,美国新生儿专家经常给轻度到中度的血小板减少症的极低出生体重儿输注血小板。

这项多中心、回顾性队列研究包括了在美国6个US NICUs进行治疗的972名极低出生体重的婴儿。数据从所有婴儿直到新生儿重症监护病房出院或死亡时进行收集。

在972名极低出生体重儿中(520名为男性;平均孕龄,28.2周),231名婴儿接受1002次血小板输注。对于998次输注中的653次(65.4%),输注前PCT至少为50000 /μL。581次输注(28.0%)在生命的前7天给予。在此期间,当PCT低于50000/μL时,53天有35天(66.0%)给予了中血小板输注,当PCT为50000/μL至99000/μL时,436天有203天(46.6%)给予了中血小板输注。当给予血小板输注时,在212血小板减少症(PCT,<100000/μL)患者-天中,198患者-天时(93.4%)出现至少一个标志,但是当没有给予血小板输注时,在190血小板减少症患者-天中,113患者-天(59.5%)出现了标志物。血小板减少是在生命的前7天中脑室内出血的危险因素。但是,血小板减少症严重程度和IVH风险之间没有相关性。在控制了显著临床因素和血小板减少症后,血小板输注没有对IVH的发病率产生显著的影响。


很大比例的血小板输注给予了血小板计数大于50000/μL的极低出生体重儿。疾病严重性影响了输注的决定。然而,血小板减少症的严重程度并不与脑室出血的风险相关,血小板输注没有降低这种风险。(文章详见——JAMA Pediatr:血小板输注并不能降低极低出生体重儿的脑室出血风险

【5】Diabetologia:低出生体重的遗传易感性可能会增加2型糖尿病风险

以前的观察性研究认为低出生体重和2型糖尿病之间的存在一定关联,但是因为社会经济和生活方式等因素的影响,两者的联系很难被证明,因此研究人员此次使用了遗传关联分析来探究这个问题。

Qi和同事对3627名2型糖尿病成年患者和12974名健康对照组进行了研究。基于5个与低出生体重相关的单核苷酸多态性(SNPs)计算遗传风险评分(GRS),并检查了GRS与2型糖尿病个体单核苷酸多态性之间的关联。研究人员进行了一个孟德尔随机分析低出生体重对2型糖尿病的因果效应的大小。结果显示,低出生体重的遗传易感性可能会增加在以后的生活中发展为2型糖尿病的风险。

对两项研究的荟萃分析显示,GRS每1个点的增量与2型糖尿病风险增加6%有关。这5个SNPs中,CCNL1 rs900400与低出生体重关联最强,其次是5q11.2 rs4432842。

研究人员还观察到,遗传决定的出生体重每下降1SD,孟德尔随机化的2型糖尿病风险。(文章详见——Diabetologia:低出生体重的遗传易感性可能会增加2型糖尿病风险



【6】低出生体重儿更易患病和贫穷

JAMA Pediatrics的一项研究表明,低出生体重早产儿在晚年时更易出现健康问题和贫穷。

安大略省麦克马斯特大学的Saroj Saigal博士和同事对100名年龄范围为29-36岁的成人进行了调查,他们出生于1977-1982年,且出生时均为ELBW。研究人员评估了参与者的医疗、教育、就业、生育、社会适应能力、人际关系等信息,并与89名同时间出生且为正常体重的成人相比较。研究人员发现,共有20名出生时ELBW的成人患有神经损伤,且与出生时正常体重的成年人相比,ELBW成年人就业机会更少,工资更低。

ELBW成年人也更多表现为单身、性生活减少,相比出生时正常体重的成人而言孕育的孩子更少。这些成年人也更可能有慢性疾病,包括糖尿病和心脏病。但他们很少出现药物或酒精的依赖。研究人员发现没有两组成人的社会交往能力没有明显差异,教育水平也无明显差异。 除外20名有神经缺陷的成年人,研究人员发现ELBW成年人更易出现同性恋和双性恋。(文章详见——JAMA pediatrics:低出生体重儿更易患病和贫穷

【7】BMJ研究新闻:低出生体重与婴儿及青少年时期较高的死亡率有关

自卡蒂夫大学的一项新的研究表明,低出生体重与婴儿期、儿童期及青春期死亡率的增加有关,该研究结果强调了女性孕前健康的重要性。

研究纳入了12355251名婴儿,根据出生体重进行分类,极低出生体重儿是指体重在500-1499g(139608名)的婴儿,低出生体重儿的体重为1500-2499g(759283名)。将正常出生体重婴儿分为两组:2500-3499g和≥3500g。

随访发现,74890名(0.61%)儿童在出生至18岁时死亡。超四分之三的死亡发生在1岁之前,23%的死亡发生在1-18岁。校正混杂因素后低出生体重儿的死亡率在1岁之前及童年晚期均较高。极低出生体重儿婴儿期的死亡率较出生体重≥3500g的婴儿高100倍,较低出生体重儿高10倍。

围产期因素,特别是呼吸系统疾病和感染,是极低出生体重儿婴儿期死亡的主要因素(84%),同样也是低出生体重儿死亡的常见因素(31%)。先天性畸形造成35% 的低出生体重儿死亡,同时是造成50% 的体重≥2500g(正常)婴儿死亡的原因。

极低出生体重儿1-18岁死亡的风险增加了近7倍,低出生体重儿则增加了3倍。1岁以上儿童死亡的原因较多。围产期因素仍是导致极低出生体重儿死亡的主要原因,正如先天性畸形是500-2499g出生体重婴儿死亡的主要原因一样,但是在出生体重≥2500g的婴儿中却并非如此。神经系统相关的疾病,特别是脑瘫,也是造成死亡的常见原因:极低出生体重儿脑瘫的比率为16.5,低出生体重儿的脑瘫比率为4.3。(文章详见——BMJ研究新闻:低出生体重与婴儿及青少年时期较高的死亡率有关


本文系梅斯医学(MedSci)原创编译整理,转载需授权!


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=134575, encodeId=d1801345e5c2, content=整理对我很好,系统学习新知识,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Sat Sep 24 21:37:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380558, encodeId=e10c138055830, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440731, encodeId=07531440e312a, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31427, encryptionId=f99e3142e4d, topicName=出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ffd4758992, createdName=ms9608593228839890, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571473, encodeId=f2d215e14732e, content=<a href='/topic/show?id=d13c26153fd' target=_blank style='color:#2F92EE;'>#低出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26153, encryptionId=d13c26153fd, topicName=低出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5e7915741670, createdName=linne325, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129907, encodeId=8f9a12990e7f, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sun Sep 18 08:09:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129871, encodeId=6db01298e1c1, content=学习新知识,更重要的是总结和理顺知识点,全面系统,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Sun Sep 18 06:52:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129866, encodeId=feb812986650, content=阅读了谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 18 06:49:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129770, encodeId=402a129e708e, content=很好的内容,继续学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ceb079804, createdName=lhl629, createdTime=Sat Sep 17 22:31:00 CST 2016, time=2016-09-17, status=1, ipAttribution=)]
    2016-09-24 舒心和人

    整理对我很好,系统学习新知识,感谢分享

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=134575, encodeId=d1801345e5c2, content=整理对我很好,系统学习新知识,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Sat Sep 24 21:37:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380558, encodeId=e10c138055830, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440731, encodeId=07531440e312a, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31427, encryptionId=f99e3142e4d, topicName=出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ffd4758992, createdName=ms9608593228839890, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571473, encodeId=f2d215e14732e, content=<a href='/topic/show?id=d13c26153fd' target=_blank style='color:#2F92EE;'>#低出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26153, encryptionId=d13c26153fd, topicName=低出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5e7915741670, createdName=linne325, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129907, encodeId=8f9a12990e7f, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sun Sep 18 08:09:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129871, encodeId=6db01298e1c1, content=学习新知识,更重要的是总结和理顺知识点,全面系统,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Sun Sep 18 06:52:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129866, encodeId=feb812986650, content=阅读了谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 18 06:49:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129770, encodeId=402a129e708e, content=很好的内容,继续学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ceb079804, createdName=lhl629, createdTime=Sat Sep 17 22:31:00 CST 2016, time=2016-09-17, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=134575, encodeId=d1801345e5c2, content=整理对我很好,系统学习新知识,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Sat Sep 24 21:37:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380558, encodeId=e10c138055830, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440731, encodeId=07531440e312a, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31427, encryptionId=f99e3142e4d, topicName=出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ffd4758992, createdName=ms9608593228839890, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571473, encodeId=f2d215e14732e, content=<a href='/topic/show?id=d13c26153fd' target=_blank style='color:#2F92EE;'>#低出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26153, encryptionId=d13c26153fd, topicName=低出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5e7915741670, createdName=linne325, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129907, encodeId=8f9a12990e7f, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sun Sep 18 08:09:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129871, encodeId=6db01298e1c1, content=学习新知识,更重要的是总结和理顺知识点,全面系统,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Sun Sep 18 06:52:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129866, encodeId=feb812986650, content=阅读了谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 18 06:49:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129770, encodeId=402a129e708e, content=很好的内容,继续学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ceb079804, createdName=lhl629, createdTime=Sat Sep 17 22:31:00 CST 2016, time=2016-09-17, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=134575, encodeId=d1801345e5c2, content=整理对我很好,系统学习新知识,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Sat Sep 24 21:37:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380558, encodeId=e10c138055830, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440731, encodeId=07531440e312a, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31427, encryptionId=f99e3142e4d, topicName=出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ffd4758992, createdName=ms9608593228839890, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571473, encodeId=f2d215e14732e, content=<a href='/topic/show?id=d13c26153fd' target=_blank style='color:#2F92EE;'>#低出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26153, encryptionId=d13c26153fd, topicName=低出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5e7915741670, createdName=linne325, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129907, encodeId=8f9a12990e7f, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sun Sep 18 08:09:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129871, encodeId=6db01298e1c1, content=学习新知识,更重要的是总结和理顺知识点,全面系统,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Sun Sep 18 06:52:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129866, encodeId=feb812986650, content=阅读了谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 18 06:49:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129770, encodeId=402a129e708e, content=很好的内容,继续学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ceb079804, createdName=lhl629, createdTime=Sat Sep 17 22:31:00 CST 2016, time=2016-09-17, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=134575, encodeId=d1801345e5c2, content=整理对我很好,系统学习新知识,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Sat Sep 24 21:37:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380558, encodeId=e10c138055830, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440731, encodeId=07531440e312a, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31427, encryptionId=f99e3142e4d, topicName=出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ffd4758992, createdName=ms9608593228839890, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571473, encodeId=f2d215e14732e, content=<a href='/topic/show?id=d13c26153fd' target=_blank style='color:#2F92EE;'>#低出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26153, encryptionId=d13c26153fd, topicName=低出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5e7915741670, createdName=linne325, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129907, encodeId=8f9a12990e7f, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sun Sep 18 08:09:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129871, encodeId=6db01298e1c1, content=学习新知识,更重要的是总结和理顺知识点,全面系统,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Sun Sep 18 06:52:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129866, encodeId=feb812986650, content=阅读了谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 18 06:49:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129770, encodeId=402a129e708e, content=很好的内容,继续学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ceb079804, createdName=lhl629, createdTime=Sat Sep 17 22:31:00 CST 2016, time=2016-09-17, status=1, ipAttribution=)]
    2016-09-18 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=134575, encodeId=d1801345e5c2, content=整理对我很好,系统学习新知识,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Sat Sep 24 21:37:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380558, encodeId=e10c138055830, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440731, encodeId=07531440e312a, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31427, encryptionId=f99e3142e4d, topicName=出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ffd4758992, createdName=ms9608593228839890, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571473, encodeId=f2d215e14732e, content=<a href='/topic/show?id=d13c26153fd' target=_blank style='color:#2F92EE;'>#低出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26153, encryptionId=d13c26153fd, topicName=低出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5e7915741670, createdName=linne325, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129907, encodeId=8f9a12990e7f, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sun Sep 18 08:09:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129871, encodeId=6db01298e1c1, content=学习新知识,更重要的是总结和理顺知识点,全面系统,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Sun Sep 18 06:52:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129866, encodeId=feb812986650, content=阅读了谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 18 06:49:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129770, encodeId=402a129e708e, content=很好的内容,继续学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ceb079804, createdName=lhl629, createdTime=Sat Sep 17 22:31:00 CST 2016, time=2016-09-17, status=1, ipAttribution=)]
    2016-09-18 zibozhouping

    学习新知识,更重要的是总结和理顺知识点,全面系统,谢谢。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=134575, encodeId=d1801345e5c2, content=整理对我很好,系统学习新知识,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Sat Sep 24 21:37:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380558, encodeId=e10c138055830, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440731, encodeId=07531440e312a, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31427, encryptionId=f99e3142e4d, topicName=出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ffd4758992, createdName=ms9608593228839890, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571473, encodeId=f2d215e14732e, content=<a href='/topic/show?id=d13c26153fd' target=_blank style='color:#2F92EE;'>#低出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26153, encryptionId=d13c26153fd, topicName=低出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5e7915741670, createdName=linne325, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129907, encodeId=8f9a12990e7f, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sun Sep 18 08:09:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129871, encodeId=6db01298e1c1, content=学习新知识,更重要的是总结和理顺知识点,全面系统,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Sun Sep 18 06:52:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129866, encodeId=feb812986650, content=阅读了谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 18 06:49:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129770, encodeId=402a129e708e, content=很好的内容,继续学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ceb079804, createdName=lhl629, createdTime=Sat Sep 17 22:31:00 CST 2016, time=2016-09-17, status=1, ipAttribution=)]
    2016-09-18 刘煜

    阅读了谢谢。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=134575, encodeId=d1801345e5c2, content=整理对我很好,系统学习新知识,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Sat Sep 24 21:37:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380558, encodeId=e10c138055830, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440731, encodeId=07531440e312a, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31427, encryptionId=f99e3142e4d, topicName=出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ffd4758992, createdName=ms9608593228839890, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571473, encodeId=f2d215e14732e, content=<a href='/topic/show?id=d13c26153fd' target=_blank style='color:#2F92EE;'>#低出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26153, encryptionId=d13c26153fd, topicName=低出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5e7915741670, createdName=linne325, createdTime=Mon Sep 19 11:06:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129907, encodeId=8f9a12990e7f, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sun Sep 18 08:09:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129871, encodeId=6db01298e1c1, content=学习新知识,更重要的是总结和理顺知识点,全面系统,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Sun Sep 18 06:52:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129866, encodeId=feb812986650, content=阅读了谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Sep 18 06:49:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129770, encodeId=402a129e708e, content=很好的内容,继续学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ceb079804, createdName=lhl629, createdTime=Sat Sep 17 22:31:00 CST 2016, time=2016-09-17, status=1, ipAttribution=)]
    2016-09-17 lhl629

    很好的内容,继续学习。

    0

相关资讯

BMJ研究新闻:低出生体重与婴儿及青少年时期较高的死亡率有关

BMJ研究新闻:低出生体重与婴儿及青少年时期较高的死亡率有关来自卡蒂夫大学的一项新的研究表明,低出生体重与婴儿期、儿童期及青春期死亡率的增加有关,该研究结果强调了女性孕前健康的重要性。研究人员随访了1993年1月1日至2011年12月31日出生的所有活产婴儿。最后共纳入了12355251名婴儿,根据出生体重进行分类,极低出生体重儿是指体重在500-1499g(139608名)的婴儿,低出生体重儿的

J Periodontol:母体的血糖水平对牙周炎与低出生体重儿关联的影响

J Periodontol:母体的血糖水平对牙周炎与低出生体重儿关联的影响本研究旨在确定血糖水平对牙周炎及低出生体重儿关联的影响。采用病例对照研究纳入了372名女性,分为病例组(109名女性,其新生儿体重<2500g)和对照组(263名女性,其新生儿体重≥2500g)。通过访谈获得研究对象的社会人口学信息、生活方式和健康状况。测量所有研究对象的糖化血糖水平(HbA1c),牙周袋探诊深度,临床附着水

Arch Gynecol Obstet:β-地中海贫血孕妇分娩出低出生体重儿的风险增加

本研究比较了患有β-地中海贫血的孕妇与正常孕妇的分娩预后。在这项回顾性队列研究中,研究人员收纳了单胎合并β地中海贫血的孕妇以及正常孕妇,并将受试者按照2:1的比例随机分配到对照组和研究组。所收纳的受试者都是低危妊娠,没有潜在的内科疾病和胎儿畸形疾病。接受侵入性产前诊断的孕妇被排除在外。本研究共纳入597例地中海贫血孕妇和1194例正常孕妇。两组的基线特征和分娩预后都相似,除了研究组的血红蛋白水平稍

ECE 2016:早产儿或低体重出生儿的骨质疏松风险可能会更高

2016年欧洲内分泌学会上一项研究表明,早产或或低出生体重儿今后骨骼强度弱于足月儿,且出现骨折和骨质疏松症的风险更高。研究人员呼吁高危民众多摄入富含钙、维生素D和蛋白质的饮食,适当进行锻炼。 在世界范围内,约有10%的婴儿为早产儿。人体骨骼对钙的吸收集中在妊娠晚期,如果此时胎儿摄取钙受限或出现早产,婴儿今后的骨骼健康状况则十分堪忧。 挪威科技大学的研究人员调查了186名年龄范围为26-28岁的成年

Hypertension:孕前高血压与低出生体重和小于胎龄儿风险有关吗?

最终研究结果并不支持孕前高血压患者或血压较高与LBW或SGA的风险增加之间存在关联。