J Clin Endocrinol Metab:卵巢储备功能过低或是女性不孕不育的一个病因

2016-07-09 MedSci MedSci原创

对于不孕不育女性来说,是否会表现出卵巢老化加速和卵巢储备过低尚未可知。本研究旨在对比可育和不育女性其窦卵泡数(AFC)年龄相关的下降程度,AFC是代表卵巢储备功能的一种生物标志物。研究涉及了西班牙的13个生育中心,纳入18-45岁参与生育中心的女性,无论是寻求生育治疗的患者还是潜在的卵母细胞捐助者。主要研究结果为这些女性年龄相关的AFC的下降程度。月经周期第2-4天评估参与者的标准 AFC。最后共

对于不孕不育女性来说,是否会表现出卵巢老化加速和卵巢储备过低尚未可知。本研究旨在对比可育和不育女性其窦卵泡数(AFC)年龄相关的下降程度,AFC是代表卵巢储备功能的一种生物标志物。

研究涉及了西班牙的13个生育中心,纳入18-45岁参与生育中心的女性,无论是寻求生育治疗的患者还是潜在的卵母细胞捐助者。

主要研究结果为这些女性年龄相关的AFC的下降程度。月经周期第2-4天评估参与者的标准 AFC。

最后共纳入15500名女性,其中5722名为潜在的卵母细胞捐助者,9778名为寻求生育治疗的患者。潜在的卵母细胞捐助者的平均AFC高于寻求生育治疗的患者(20 VS. 10),校正年龄后两组参与者仍存在差异。与潜在的卵母细胞捐助者相比,不孕女性其年龄相关的AFC下降更为迅猛,且各年龄段患者的卵巢储备功能低下(AFC<5)的发生率更高。

总而言之,该研究发现,与潜在的卵母细胞捐助者相比,不孕女性其年龄相关的AFC下降的更为明显。卵巢储备功能过低可能是导致女性不孕的另一个功能性原因。

原始出处:

Iliodromiti S, et al. Excessive age-related decline in functional ovarian reserve in infertile women: prospective cohort of 15,500 women.  J Clin Endocrinol Metab. 2016;doi;10.1210/jc.2015-4279.


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  1. [GetPortalCommentsPageByObjectIdResponse(id=1887543, encodeId=d543188e543b2, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Mar 31 17:02:00 CST 2017, time=2017-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895928, encodeId=6af8189592847, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Tue Jul 12 13:02:00 CST 2016, time=2016-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=132033, encodeId=dca8132033e1, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 21 08:16:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125700, encodeId=9e2a125e0094, content=感谢分享,很有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 20:43:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355076, encodeId=a3fa13550e638, content=<a href='/topic/show?id=b9e02036159' target=_blank style='color:#2F92EE;'>#不孕不育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20361, encryptionId=b9e02036159, topicName=不孕不育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 11 13:02:00 CST 2016, time=2016-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582117, encodeId=0d2a158211e7b, content=<a href='/topic/show?id=4f69368325b' target=_blank style='color:#2F92EE;'>#卵巢储备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36832, encryptionId=4f69368325b, topicName=卵巢储备)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=086316885790, createdName=haouestc, createdTime=Mon Jul 11 13:02:00 CST 2016, time=2016-07-11, status=1, ipAttribution=)]
    2017-03-31 guojianrong
  2. [GetPortalCommentsPageByObjectIdResponse(id=1887543, encodeId=d543188e543b2, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Mar 31 17:02:00 CST 2017, time=2017-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895928, encodeId=6af8189592847, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Tue Jul 12 13:02:00 CST 2016, time=2016-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=132033, encodeId=dca8132033e1, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 21 08:16:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125700, encodeId=9e2a125e0094, content=感谢分享,很有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 20:43:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355076, encodeId=a3fa13550e638, content=<a href='/topic/show?id=b9e02036159' target=_blank style='color:#2F92EE;'>#不孕不育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20361, encryptionId=b9e02036159, topicName=不孕不育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 11 13:02:00 CST 2016, time=2016-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582117, encodeId=0d2a158211e7b, content=<a href='/topic/show?id=4f69368325b' target=_blank style='color:#2F92EE;'>#卵巢储备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36832, encryptionId=4f69368325b, topicName=卵巢储备)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=086316885790, createdName=haouestc, createdTime=Mon Jul 11 13:02:00 CST 2016, time=2016-07-11, status=1, ipAttribution=)]
    2016-07-12 一闲
  3. [GetPortalCommentsPageByObjectIdResponse(id=1887543, encodeId=d543188e543b2, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Mar 31 17:02:00 CST 2017, time=2017-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895928, encodeId=6af8189592847, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Tue Jul 12 13:02:00 CST 2016, time=2016-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=132033, encodeId=dca8132033e1, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 21 08:16:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125700, encodeId=9e2a125e0094, content=感谢分享,很有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 20:43:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355076, encodeId=a3fa13550e638, content=<a href='/topic/show?id=b9e02036159' target=_blank style='color:#2F92EE;'>#不孕不育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20361, encryptionId=b9e02036159, topicName=不孕不育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 11 13:02:00 CST 2016, time=2016-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582117, encodeId=0d2a158211e7b, content=<a href='/topic/show?id=4f69368325b' target=_blank style='color:#2F92EE;'>#卵巢储备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36832, encryptionId=4f69368325b, topicName=卵巢储备)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=086316885790, createdName=haouestc, createdTime=Mon Jul 11 13:02:00 CST 2016, time=2016-07-11, status=1, ipAttribution=)]
    2016-09-21 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

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    2016-09-13 舒心和人

    感谢分享,很有道理

    0

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