Diabetes Care：补充维生素D无助于糖尿病前期人群控制血糖或心血管危险因素

2014-06-25 CMT 中国医学论坛报CMT糖尿病微信

挪威一项研究显示，补充维生素D不能改善糖尿病前期人群的血糖、血压或血脂水平。论文6月19日在线发表于《糖尿病护理》(Diabetes Care)杂志。既往有观察性研究显示，血清25-羟维生素[25(OH)D] 浓度低与胰岛素抵抗及其他心血管病危险因素相关。研究者进行了一项为期5年的试验，纳入511例空腹血糖受损(IFG)和/或糖耐量减低(IGT)者，随机分为2组，一组接受20000 IU/周维

挪威一项研究显示，补充维生素D不能改善糖尿病前期人群的血糖、血压或血脂水平。论文6月19日在线发表于《糖尿病护理》(Diabetes Care)杂志。

既往有观察性研究显示，血清25-羟维生素[25(OH)D] 浓度低与胰岛素抵抗及其他心血管病危险因素相关。研究者进行了一项为期5年的试验，纳入511例空腹血糖受损(IFG)和/或糖耐量减低(IGT)者，随机分为2组，一组接受20000 IU/周维生素D3(维生素D组)，另一组接受安慰剂。论文呈现的是该研究的1年数据。

结果为，维生素D组和安慰剂组平均基线血清25(OH)D水平分别为59.9 nmol/L and 61.1 nmol/L，1年时分别增加45.8nmol/L和3.4 nmol/L。校正基线浓度后，1年后两组在糖代谢指标、胰岛素分泌或敏感性、血压、高敏C反应蛋白(hs-CRP)等指标方面无显著差异。与安慰剂组相比，维生素D组总胆固醇和低密度脂蛋白胆固醇(LDL-C)水平轻度降低，差异具有统计学意义;但维生素D组高密度脂蛋白胆固醇(HDL-C)水平也降低，总胆固醇/HDL-C比值变化无显著差异。如果只分析25(OH)D<50 nmol/L者的数据，结果未发生变化。

原始出处：

Sollid ST1, Hutchinson MY2, Fuskevåg OM3, Figenschau Y4, Joakimsen RM5, Schirmer H6, Njølstad I7, Svartberg J5, Kamycheva E8, Jorde R5.No Effect of High-Dose Vitamin D Supplementation on Glycemic Status or Cardiovascular Risk Factors in Subjects With Prediabetes.Diabetes Care. 2014 Jun 19. pii: DC_140218. [Epub ahead of print]

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2014-08-25 s_pl2008

#控制血糖#

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2015-04-11 x35042875

国真实妊娠糖尿病患病率应该在这两种方案得到的患病率之间

163 0
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2015-03-08 智智灵药

#BET#

41 0
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2014-11-28 木头人513

#Diabetes#

34 0
[GetPortalCommentsPageByObjectIdResponse(id=1934532, encodeId=12821934532a1, content=<a href='/topic/show?id=b65a56e400e' target=_blank style='color:#2F92EE;'>#控制血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56740, encryptionId=b65a56e400e, topicName=控制血糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=71f1477, createdName=s_pl2008, createdTime=Mon Aug 25 03:47:00 CST 2014, time=2014-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20736, encodeId=bdba20e36d1, content=国真实妊娠糖尿病患病率应该在这两种方案得到的患病率之间, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:39:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759468, encodeId=ac081e5946850, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Mar 08 19:47:00 CST 2015, time=2015-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901227, encodeId=7a6d190122ef0, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri Nov 28 11:47:00 CST 2014, time=2014-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636900, encodeId=a9bb1636900f0, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Jan 10 03:47:00 CST 2015, time=2015-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948890, encodeId=9b0a194889019, content=<a href='/topic/show?id=1e4789584b0' target=_blank style='color:#2F92EE;'>#血管危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89584, encryptionId=1e4789584b0, topicName=血管危险因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Nov 29 20:47:00 CST 2014, time=2014-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331457, encodeId=92df133145ed2, content=<a href='/topic/show?id=afab51e831d' target=_blank style='color:#2F92EE;'>#心血管危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51783, encryptionId=afab51e831d, topicName=心血管危险因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Fri Jun 27 01:47:00 CST 2014, time=2014-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629741, encodeId=95ce1629e419a, content=<a href='/topic/show?id=28c351e80dc' target=_blank style='color:#2F92EE;'>#心血管危险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51780, encryptionId=28c351e80dc, topicName=心血管危险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3e0221357465, createdName=lingaifan, createdTime=Fri Jun 27 01:47:00 CST 2014, time=2014-06-27, status=1, ipAttribution=)]
2015-01-10 ms9608593228839890

#DIA#

37 0
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2014-11-29 xinmeili

#血管危险因素#

39 0
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2014-06-27 yuhaisheng_ibp_32061711

#心血管危险因素#

47 0
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2014-06-27 lingaifan

#心血管危险#

47 0

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Diabetes Care：补充维生素D无助于糖尿病前期人群控制血糖或心血管危险因素

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