Lasers Med Sci:新型PSNC膜可有效促进骨修复

2018-06-24 MedSci MedSci原创

生物相容性膜在医学广泛应用以刺激骨修复。几项研究表明,激光光生物调节(PBM)也可刺激骨折部位成骨细胞的增殖和骨生成,导致更大的骨量沉积,并加速骨固结过程。这项工作评估了780 nm激光PBM和涂有降脂欣和胶原蛋白(PSNC)的聚苯乙烯膜对颅骨骨缺损大鼠骨愈合的治疗效果。使用组织学染色、拉曼光谱和扫描电子显微镜(SEM)评估骨修复过程。比较四个实验处理组:C,对照组;M,仅膜;L,仅激光PBM和M

生物相容性膜在医学广泛应用以刺激骨修复。几项研究表明,激光光生物调节(PBM)也可刺激骨折部位成骨细胞的增殖和骨生成,导致更大的骨量沉积,并加速骨固结过程。这项工作评估了780 nm激光PBM和涂有降脂欣和胶原蛋白(PSNC)的聚苯乙烯膜对颅骨骨缺损大鼠骨愈合的治疗效果。

使用组织学染色、拉曼光谱和扫描电子显微镜(SEM)评估骨修复过程。比较四个实验处理组:C,对照组;M,仅膜;L,仅激光PBM和ML,膜+激光PBM。在每只动物的颅盖上形成骨缺损,每组动物分成两个亚组,在治疗15和30天后接受安乐死。术后隔日照射L和ML组(λ= 780nm,ED = 6J/cm 2,P = 60mW,t = 4s),直到它们被安乐死。结果显示,羟磷灰石(CHA)的骨浓度随着磷酸盐面积增加,在15和30天,B阶(正常皮质骨)> L> M> ML> C。

结果显示,PSNC膜可有效减少炎症过程,并可作为骨修复的支架。激光PBM还显示出对骨修复过程的积极作用,增加新形成的骨的沉积和组织。然而,激光PBM未能改善膜支架的生物活性。

原始出处:

Alves AMM, de Miranda Fortaleza LM, et al., Evaluation of bone repair after application of a norbixin membrane scaffold with and without laser photobiomodulation (λ 780 nm). Lasers Med Sci. 2018 May 4. doi: 10.1007/s10103-018-2506-9. 

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    2019-03-29 axin020
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    2019-01-04 anminleiryan
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    2018-06-25 飛歌

    学习了很有用

    0

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    2018-06-25 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-06-24 虈亣靌

    学习学习谢谢分享

    0

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    2018-06-24 虈亣靌

    学习学习谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1719490, encodeId=0df21e1949050, content=<a href='/topic/show?id=17641015914f' target=_blank style='color:#2F92EE;'>#骨修复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101591, encryptionId=17641015914f, topicName=骨修复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a5232746261, createdName=axin020, createdTime=Fri Mar 29 17:21:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878270, encodeId=8a6818e82703c, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Fri Jan 04 15:21:00 CST 2019, time=2019-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608899, encodeId=747b160889990, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Jun 26 14:21:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326765, encodeId=855e326e65a8, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Jun 25 00:30:33 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326747, encodeId=3572326e4709, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jun 25 00:07:03 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326735, encodeId=1698326e35a7, content=学习学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jun 24 23:52:23 CST 2018, time=2018-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326734, encodeId=3300326e340e, content=学习学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jun 24 23:49:47 CST 2018, time=2018-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326717, encodeId=a343326e17dc, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Jun 24 23:30:40 CST 2018, time=2018-06-24, status=1, ipAttribution=)]
    2018-06-24 惠映实验室

    学习了.谢谢分享.

    0