肿瘤科

订阅

MedSci主页 / 所有栏目 / 肿瘤科

抗白血病化合物MI-3454可诱导小鼠模型完全缓解

2020-02-08 Allan MedSci原创

MI-3454抗白血病化合物小鼠模型MLL1蛋白
关注

美国密歇根大学开发的一种抗癌化合物在小鼠模型中显示出对白血病的高度活性，该化合物被称为MI-3454，可抑制Menin与MLL1蛋白之间的蛋白质相互作用。

美国密歇根大学开发的一种抗癌化合物在小鼠模型中显示出对白血病的高度活性，该化合物被称为MI-3454，可抑制Menin与MLL1蛋白之间的蛋白质相互作用。将具有高表达MLL1基因的患者来源的肿瘤细胞移植进小鼠体内，MI-3454诱导了小鼠体内肿瘤的完全缓解。成人急性白血病患者中有5％至10％具有MLL1基因重排，婴儿急性淋巴细胞白血病中有80％具有MLL1基因重排。

该化合物还导致具有NPM1基因突变的白血病模型中的淋巴母细胞大量减少，NPM1基因突变存在于大约30％的急性髓细胞性白血病病例中。密歇根州立大学的病理学副教授Jolanta Grembecka博士说：“只有约三分之一的MLL1基因重排患者能够存活五年，因此迫切需要新的治疗方法”。


原始出处：

https://www.firstwordpharma.com/node/1699047

本文系梅斯医学（MedSci）原创编译整理，转载需授权!

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1642468, encodeId=ead6164246853, content=<a href='/topic/show?id=842f458e61f' target=_blank style='color:#2F92EE;'>#完全缓解#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45876, encryptionId=842f458e61f, topicName=完全缓解)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b5d22942638, createdName=小小小向日葵, createdTime=Mon Sep 07 07:35:00 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746662, encodeId=12b61e46662b1, content=<a href='/topic/show?id=c36e1168247' target=_blank style='color:#2F92EE;'>#MI-3454#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11682, encryptionId=c36e1168247, topicName=MI-3454)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=501235820538, createdName=zsyan, createdTime=Thu Aug 20 17:35:00 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906432, encodeId=adb819064324f, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sat Jan 23 06:35:00 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953319, encodeId=3e46195331935, content=<a href='/topic/show?id=299d5556490' target=_blank style='color:#2F92EE;'>#抗白血病化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55564, encryptionId=299d5556490, topicName=抗白血病化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Fri Jan 01 05:35:00 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436804, encodeId=8bb414368046c, content=<a href='/topic/show?id=a9424e199a5' target=_blank style='color:#2F92EE;'>#小鼠模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47199, encryptionId=a9424e199a5, topicName=小鼠模型)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Feb 10 09:35:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047765, encodeId=5c60104e7658e, content=梅斯里提供了很多疾病的模型计算公式，赞一个！, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Feb 08 21:35:00 CST 2020, time=2020-02-08, status=1, ipAttribution=)]
    2020-09-07 小小小向日葵

    #完全缓解#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1642468, encodeId=ead6164246853, content=<a href='/topic/show?id=842f458e61f' target=_blank style='color:#2F92EE;'>#完全缓解#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45876, encryptionId=842f458e61f, topicName=完全缓解)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b5d22942638, createdName=小小小向日葵, createdTime=Mon Sep 07 07:35:00 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746662, encodeId=12b61e46662b1, content=<a href='/topic/show?id=c36e1168247' target=_blank style='color:#2F92EE;'>#MI-3454#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11682, encryptionId=c36e1168247, topicName=MI-3454)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=501235820538, createdName=zsyan, createdTime=Thu Aug 20 17:35:00 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906432, encodeId=adb819064324f, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sat Jan 23 06:35:00 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953319, encodeId=3e46195331935, content=<a href='/topic/show?id=299d5556490' target=_blank style='color:#2F92EE;'>#抗白血病化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55564, encryptionId=299d5556490, topicName=抗白血病化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Fri Jan 01 05:35:00 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436804, encodeId=8bb414368046c, content=<a href='/topic/show?id=a9424e199a5' target=_blank style='color:#2F92EE;'>#小鼠模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47199, encryptionId=a9424e199a5, topicName=小鼠模型)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Feb 10 09:35:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047765, encodeId=5c60104e7658e, content=梅斯里提供了很多疾病的模型计算公式，赞一个！, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Feb 08 21:35:00 CST 2020, time=2020-02-08, status=1, ipAttribution=)]
    2020-08-20 zsyan

    #MI-3454#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1642468, encodeId=ead6164246853, content=<a href='/topic/show?id=842f458e61f' target=_blank style='color:#2F92EE;'>#完全缓解#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45876, encryptionId=842f458e61f, topicName=完全缓解)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b5d22942638, createdName=小小小向日葵, createdTime=Mon Sep 07 07:35:00 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746662, encodeId=12b61e46662b1, content=<a href='/topic/show?id=c36e1168247' target=_blank style='color:#2F92EE;'>#MI-3454#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11682, encryptionId=c36e1168247, topicName=MI-3454)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=501235820538, createdName=zsyan, createdTime=Thu Aug 20 17:35:00 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906432, encodeId=adb819064324f, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sat Jan 23 06:35:00 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953319, encodeId=3e46195331935, content=<a href='/topic/show?id=299d5556490' target=_blank style='color:#2F92EE;'>#抗白血病化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55564, encryptionId=299d5556490, topicName=抗白血病化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Fri Jan 01 05:35:00 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436804, encodeId=8bb414368046c, content=<a href='/topic/show?id=a9424e199a5' target=_blank style='color:#2F92EE;'>#小鼠模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47199, encryptionId=a9424e199a5, topicName=小鼠模型)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Feb 10 09:35:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047765, encodeId=5c60104e7658e, content=梅斯里提供了很多疾病的模型计算公式，赞一个！, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Feb 08 21:35:00 CST 2020, time=2020-02-08, status=1, ipAttribution=)]
    2021-01-23 wangyang7958

    #化合物#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1642468, encodeId=ead6164246853, content=<a href='/topic/show?id=842f458e61f' target=_blank style='color:#2F92EE;'>#完全缓解#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45876, encryptionId=842f458e61f, topicName=完全缓解)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b5d22942638, createdName=小小小向日葵, createdTime=Mon Sep 07 07:35:00 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746662, encodeId=12b61e46662b1, content=<a href='/topic/show?id=c36e1168247' target=_blank style='color:#2F92EE;'>#MI-3454#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11682, encryptionId=c36e1168247, topicName=MI-3454)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=501235820538, createdName=zsyan, createdTime=Thu Aug 20 17:35:00 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906432, encodeId=adb819064324f, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sat Jan 23 06:35:00 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953319, encodeId=3e46195331935, content=<a href='/topic/show?id=299d5556490' target=_blank style='color:#2F92EE;'>#抗白血病化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55564, encryptionId=299d5556490, topicName=抗白血病化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Fri Jan 01 05:35:00 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436804, encodeId=8bb414368046c, content=<a href='/topic/show?id=a9424e199a5' target=_blank style='color:#2F92EE;'>#小鼠模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47199, encryptionId=a9424e199a5, topicName=小鼠模型)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Feb 10 09:35:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047765, encodeId=5c60104e7658e, content=梅斯里提供了很多疾病的模型计算公式，赞一个！, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Feb 08 21:35:00 CST 2020, time=2020-02-08, status=1, ipAttribution=)]
    2021-01-01 chaojitidian

    #抗白血病化合物#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1642468, encodeId=ead6164246853, content=<a href='/topic/show?id=842f458e61f' target=_blank style='color:#2F92EE;'>#完全缓解#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45876, encryptionId=842f458e61f, topicName=完全缓解)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b5d22942638, createdName=小小小向日葵, createdTime=Mon Sep 07 07:35:00 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746662, encodeId=12b61e46662b1, content=<a href='/topic/show?id=c36e1168247' target=_blank style='color:#2F92EE;'>#MI-3454#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11682, encryptionId=c36e1168247, topicName=MI-3454)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=501235820538, createdName=zsyan, createdTime=Thu Aug 20 17:35:00 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906432, encodeId=adb819064324f, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sat Jan 23 06:35:00 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953319, encodeId=3e46195331935, content=<a href='/topic/show?id=299d5556490' target=_blank style='color:#2F92EE;'>#抗白血病化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55564, encryptionId=299d5556490, topicName=抗白血病化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Fri Jan 01 05:35:00 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436804, encodeId=8bb414368046c, content=<a href='/topic/show?id=a9424e199a5' target=_blank style='color:#2F92EE;'>#小鼠模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47199, encryptionId=a9424e199a5, topicName=小鼠模型)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Feb 10 09:35:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047765, encodeId=5c60104e7658e, content=梅斯里提供了很多疾病的模型计算公式，赞一个！, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Feb 08 21:35:00 CST 2020, time=2020-02-08, status=1, ipAttribution=)]
    2020-02-10 zhouqu_8

    #小鼠模型#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1642468, encodeId=ead6164246853, content=<a href='/topic/show?id=842f458e61f' target=_blank style='color:#2F92EE;'>#完全缓解#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45876, encryptionId=842f458e61f, topicName=完全缓解)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b5d22942638, createdName=小小小向日葵, createdTime=Mon Sep 07 07:35:00 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746662, encodeId=12b61e46662b1, content=<a href='/topic/show?id=c36e1168247' target=_blank style='color:#2F92EE;'>#MI-3454#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11682, encryptionId=c36e1168247, topicName=MI-3454)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=501235820538, createdName=zsyan, createdTime=Thu Aug 20 17:35:00 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906432, encodeId=adb819064324f, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sat Jan 23 06:35:00 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953319, encodeId=3e46195331935, content=<a href='/topic/show?id=299d5556490' target=_blank style='color:#2F92EE;'>#抗白血病化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55564, encryptionId=299d5556490, topicName=抗白血病化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Fri Jan 01 05:35:00 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436804, encodeId=8bb414368046c, content=<a href='/topic/show?id=a9424e199a5' target=_blank style='color:#2F92EE;'>#小鼠模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47199, encryptionId=a9424e199a5, topicName=小鼠模型)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Feb 10 09:35:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047765, encodeId=5c60104e7658e, content=梅斯里提供了很多疾病的模型计算公式，赞一个！, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Feb 08 21:35:00 CST 2020, time=2020-02-08, status=1, ipAttribution=)]
    2020-02-08 CHANGE

    梅斯里提供了很多疾病的模型计算公式，赞一个！

    0