BMC Cancer：警惕！孕期药物化疗或影响所生女儿未来的生育能力

2016-08-15 佚名生物谷

图片摘自：www.sundaypost.com近日，一项刊登于国际杂志BMC Cancer上的报告称，女性怀孕期间进行化疗或会影响未出生女儿将来的生育能力。文章中研究者在实验室中研究发现，一种名为依托泊甙的药物或许能够损伤小鼠卵巢组织的发育。依托泊苷是一种细胞周期特异性抗肿瘤药物，其可以阻碍癌细胞DNA的修复。这种药物所影响的特异性细胞名为生殖细胞，其可以产生卵细胞，研究者表示他们需要后期

图片摘自：www.sundaypost.com

近日，一项刊登于国际杂志BMC Cancer上的报告称，女性怀孕期间进行化疗或会影响未出生女儿将来的生育能力。文章中研究者在实验室中研究发现，一种名为依托泊甙的药物或许能够损伤小鼠卵巢组织的发育。依托泊苷是一种细胞周期特异性抗肿瘤药物，其可以阻碍癌细胞DNA的修复。

这种药物所影响的特异性细胞名为生殖细胞，其可以产生卵细胞，研究者表示他们需要后期深入研究来评估是否依托泊苷对人类机体组织的效应同在小鼠中的效应类似。研究者指出，该研究或许意味着受影响的女孩儿在后期生活中应当警惕机体的过早停经（early menopause）。

1000名孕妇中大约有1人会被诊断为癌症，医生和患者不得不进行很难的决定来挽救母亲和婴儿的生命；而药物依托泊苷是一种治疗多种癌症的药物，其被认为可以安全用于治疗妊娠后期（2个月和3个月）的孕妇，因为这种药物引起孕妇流产和婴儿出生缺陷的风险较低。然而研究者目前并不清楚这种药物对于婴儿出生后的长期影响。

女性的“生育寿命”往往在出生前就已经确定了，在母体子宫中婴儿的卵巢就已经开始发育了，而且妊娠末期三个月和妊娠末期两个月非常关键，这时候来源于滤泡中的雌性生殖细胞往往可以确定婴儿出生后机体中所拥有的卵细胞数量。这项研究中研究者在实验室中分析了药物依托泊甙疗法对小鼠卵巢组织生长的长期效应。

研究者发现，在滤泡发育之前，这种疗法可以耗尽90%的生殖细胞，甚至患者使用极低水平的药物也会产生一定影响。然而在滤泡发育后这种疗法对婴儿机体却并没有明显的副作用。在子宫内滤泡的发育大约开始于婴儿发育17周左右，尽管到孕妇怀孕晚期阶段滤泡的发育也并不会完全完成。

最后研究者Norah Spears说道，如果这项研究结果在人类机体中也被证实的话，那么就意味着，女性怀孕期间如果进行依托泊甙疗法，那么其所生的女性或许将来就会面临生育能力较低的状况。

原始出处

Agnes Stefansdottir, Zoe C. Johnston, Nicola Powles-Glover, Richard A. Anderson, Ian R. Adams and Norah Spears.Etoposide damages female germ cells in the developing ovary.BMC Cancer.2016

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2016-09-12 ms3025846204744509

#BMC#

36 0
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2016-09-28 ylzr123

好文关注值得学习。赞！有待探究。

94 0
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2016-08-26 ylzr123

深度好文，赞一个！!！

79 0
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2016-08-16 doctorJiangchao

继续学习

90 0
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2016-08-16 doctorJiangchao

继续关注

100 0
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2016-08-15 doctorJiangchao

继续学习

102 0
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2016-08-15 doctorJiangchao

继续关注

29 0
[GetPortalCommentsPageByObjectIdResponse(id=1974691, encodeId=df1e19e469100, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Mon Sep 12 12:09:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137421, encodeId=467313e421ef, content=好文关注值得学习。赞！有待探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 28 22:43:40 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104214, encodeId=35571042148f, content=深度好文，赞一个！!！, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 26 09:14:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99504, encodeId=57f49950406, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 16 21:29:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99505, encodeId=2d17995051b, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 16 21:29:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=98947, encodeId=f6889894eba, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Aug 15 20:21:00 CST 2016, time=2016-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=98948, encodeId=ef289894859, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Aug 15 20:21:00 CST 2016, time=2016-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=98799, encodeId=b08298e99c3, content=女性怀孕期间尽量避免服用各类药物比较好, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7gGJY7ibia1wDTTwTL7vXbqvekMBTHAsd3KZ7btXM9tnHuicI2LdxJtIiccXeDCiaTvzkwMuribZ9oHVA/0, createdBy=c7b81713099, createdName=木水晶, createdTime=Mon Aug 15 11:29:00 CST 2016, time=2016-08-15, status=1, ipAttribution=)]
2016-08-15 木水晶

女性怀孕期间尽量避免服用各类药物比较好

26 0

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