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JCEM：良性甲状腺疾病与甲状腺癌的风险！

2018-03-25 xing.T MedSci原创

良性甲状腺疾病甲状腺癌风险
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由此可见，该研究发现了一个意想不到的增加分化的甲状腺癌的风险，包括区域/远处的疾病，甲状腺机能亢进和甲状腺炎的诊断，不能完全归咎于医疗监督的增加。甲状腺功能减退与甲状腺癌的风险之间的相关性不太明显。

甲状腺结节、腺瘤和甲状腺肿一直与甲状腺癌的风险有关。很少有研究评估甲状腺功能紊乱和甲状腺自身免疫是否会影响这种风险。近日，内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章。该研究旨在评估广泛的甲状腺良性疾病诊断后发生甲状腺癌的风险。

该研究以1978-2013年期间以医院肿瘤登记机构为基础进行的队列研究。参与者包括甲状腺功能亢进症（n = 85169）、甲状腺功能减退症（n = 63143）、甲状腺炎（n = 12532）、结节性甲状腺肿（n = 65782）、单纯性甲状腺肿（n = 11582）、其他未指定的甲状腺肿（n = 21953）、或腺瘤（n = 6481）患者。主要结局指标为计算的分化型甲状腺癌的标准化发病率（SIRS），而不包括甲状腺良性疾病诊断后随访头12个月内发生的甲状腺癌。

除甲状腺功能减退外，所有良性甲状腺疾病患者的SIRS显著升高。早期随访期间，男性高于女性。局部和区域/远处甲状腺癌的SIRS升高。排除随访后前10年的数据，甲状腺功能亢进症（n = 27例甲状腺癌患者，SIR= 2，95%CI为1.32-2.92）、结节性甲状腺肿（n = 83，SIR= 4.1，95% CI为3.91-6.09）、单纯性甲状腺肿（n = 8，SIR= 4.33，95%CI为1.87-8.53）、其他未定型的甲状腺肿（n = 20，SIR=3.94，95%CI为2.40-6.08）以及腺瘤（n=9，SIR=6.02，95%CI为2.76-11.5）仍然与甲状腺癌风险呈正相关。

由此可见，该研究发现了一个意想不到的增加分化的甲状腺癌的风险，包括区域/远处的疾病，甲状腺机能亢进和甲状腺炎的诊断，不能完全归咎于医疗监督的增加。甲状腺功能减退与甲状腺癌的风险之间的相关性不太明显。

原始出处：

Cari M Kitahara,et al. Benign Thyroid Diseases and Risk of Thyroid Cancer: A Nationwide Cohort Study.J Clin Endocrinol Metab. 2018. https://doi.org/10.1210/jc.2017-02599

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    2018-09-25 smallant2015

    #JCEM#

    0

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    2018-11-12 achengzhao

    #JCE#

    0

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    2018-03-26 sunfeifeiyang

    阅

    0

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    2018-03-25 yfjms

    学习

    0

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    2018-03-25 yfjms

    学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1777796, encodeId=11901e77796f0, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Tue Sep 25 13:20:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063178, encodeId=c36a20631e87a, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Mon Nov 12 22:20:00 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299879, encodeId=1b8e2998e948, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Mon Mar 26 12:43:43 CST 2018, time=2018-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299556, encodeId=00c329955683, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun Mar 25 14:55:55 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299555, encodeId=bc37299555c5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun Mar 25 14:55:02 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299549, encodeId=91b029954956, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Mar 25 14:45:55 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299541, encodeId=4bd4299541cf, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Sun Mar 25 14:34:23 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
    2018-03-25 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1777796, encodeId=11901e77796f0, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Tue Sep 25 13:20:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063178, encodeId=c36a20631e87a, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Mon Nov 12 22:20:00 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299879, encodeId=1b8e2998e948, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Mon Mar 26 12:43:43 CST 2018, time=2018-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299556, encodeId=00c329955683, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun Mar 25 14:55:55 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299555, encodeId=bc37299555c5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun Mar 25 14:55:02 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299549, encodeId=91b029954956, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Mar 25 14:45:55 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299541, encodeId=4bd4299541cf, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Sun Mar 25 14:34:23 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
    2018-03-25 神功盖世

    阅

    0