BJS：口腔癌手术切缘的遗传学分析！

2018-01-29 xing.T MedSci原创

由此可见，手术切缘的分子评估可以帮助识别有局部复发风险的患者。

组织学确定的无肿瘤手术切缘并不能保证癌症患者无复发生存。近日，外科领域权威杂志British Journal of Surgery上发表了一篇研究文章，该研究旨在调查无瘤手术切缘的微卫星改变与口腔鳞状细胞癌患者局部复发之间的关系。

这项前瞻性研究招募了组织学确诊的口腔鳞状细胞癌患者。获取的肿瘤标本为相应的手术边缘，并且留取外周血样本。使用六个二核苷酸微卫星标记来调查微卫星改变。所有样品通过PCR扩增，然后进行自动片段分析。

研究人员从145例患者中确定了100个（69.0％）微卫星改变标本。其中，85个标本携带杂合性缺失，然而，55个标本携带微卫星不稳定性（MSI）。多因素分析显示手术切缘MSI患者局部复发的风险较高（比值比为7.17,95％可信区间为3.49-14.73）。

由此可见，手术切缘的分子评估可以帮助识别有局部复发风险的患者。

原始出处：

S. A. L,et al. Genetic analysis of surgical margins in oral cavity cancer.British Journal of Surgery.2018. http://onlinelibrary.wiley.com/doi/10.1002/bjs.10693/full

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2019-01-12 chengjn

#手术切缘#

38 0
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2018-04-09 李研东

#遗传学#

37 0
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2018-02-02 1209e435m98(暂无昵称)

学习了.谢谢分享

62 0
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2018-01-29 龙胆草

学习谢谢分享

75 0
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2018-01-29 yfjms

学习

69 0
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2018-01-29 九九消寒

优质资源.共同学习

63 0
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2018-01-29 1dd8c52fm63(暂无匿称)

了解了解.学习学习

75 0

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