EHJ:LDL-C/HDL-C比例是男性患者心血管事件的有效预测因素

2013-09-04 刘揆亮 译 医学论坛网

近日,在2013年欧洲心脏病学会年会上,来自日本高松KKR高松医院的 I. Matsumoto的学者发表研究结果,研究发现,LDL-C/HDL-C比例是男性患者心血管事件的一项有价值的预测因素。次外,PCI后的二级预防需要维持LDL-C/HDL-C比例低于1.5,相关论文发表在在欧洲心脏病学杂志(European Heart Journal)(2013)34(摘要补充)

近日,在2013年欧洲心脏病学会年会上,来自日本高松KKR高松医院的 I. Matsumoto的学者发表研究结果,研究发现,LDL-C/HDL-C比例是男性患者心血管事件的一项有价值的预测因素。次外,PCI后的二级预防需要维持LDL-C/HDL-C比例低于1.5,相关论文发表在在欧洲心脏病学杂志(European Heart Journal)(2013)34(摘要补充),136。 

一些临床研究证实低密度脂蛋白胆固醇/高密度脂蛋白胆固醇(LDL-C/HDL-C)是心血管疾病的一项良好预测因素。本研究的目的是明确LDL-C/HDL-C比例是否可能影响经皮冠状动脉干预(PCI)后的转归。

877名成功进行PCI的男性患者分为以下三组:LDL-C/HDL-C≤1.5组(178)名,LDL-C/HDL-C= 1.5-2.0组(261名),LDL-C/HDL-C >2.0(438名)。在这些组中评价了PCI后5年内心血管重大不良事件(MACE)的发生率。MACE定义为心源性死亡、非致死性心肌梗死、新发狭窄和再狭窄。

Kaplan-Meier分析证实LDL-C/HDL-C≤1.5的患者与LDL-C/HDL-C>2.0及LDL-C/HDL-C 在1.5-2之间的患者相比MACE发生率明显更低(P<0.001)。另外,Cox比例风险模型表明LDL-C/HDL-C比例是MACE的独立危险因素。

   ESC 

MACE的累积发生率     

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    2013-09-06 ZGMFX24A
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    2013-09-06 zhwj
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