Neurology:椎间盘微可骨刺导致顽固性自发性颅内低压

2016-09-26 MedSci MedSci原创

研究结果表明脑脊液漏的原因是有限的纵向硬脊膜裂口,可出现在硬脊膜腹侧、背侧或外侧。硬膜外病变,椎间盘微骨刺,是所有外侧腹脑脊液漏的单一原因。这些发现挑战了顽固性自发性颅内低压患者发生脑脊液漏是特发性的或由于硬脊膜较弱的概念,显微外科手术是治疗难治性顽固性自发性颅内低压的治疗选择。

以往观点认为顽固性自发性颅内低压患者发生脑脊液漏是特发性的或由于硬脊膜较弱引起的。近日,神经病学领域权威杂志《neurology》上发表文章对这一概念进行了挑战。

研究者纳入了从2013年2月至2015年7月之间的患者,为了探究和治疗顽固性自发性颅内低压患者硬脊膜脑脊液漏,对所有患者进行脊柱显微外科手术探查,并进行检查,如有/无鞘内注射造影的脊髓MRI、动态造影、脊髓造影后CT。


研究者发现在连续的69例患者中,有15例出现顽固性颅内低压症状,系统成像显示,在这15例患者的泄漏发生在可疑的单一位置。14例患者进行了显微外科探查术,1例拒绝手术。术中,包括椎管探查,发现了引起脑脊液漏的原因是一个在硬脊膜腹侧(10例)、外侧(3例)和背侧(1例)纵向的硬脊膜裂口(6.1±1.7毫米)。10例(71%)患者硬脊膜腹侧可见起源于椎间盘孔并且钙化的微骨刺像一把刀一样将硬脊膜切开。3例(22%)患者脊髓硬脊膜外侧可见与脊膜憩室相关的硬脊膜裂口,1例(7%)患者背侧骨赘是导致硬脊膜裂开的原因。微刺拆除和硬膜切口缝合可立即阻止脑脊液漏。

研究结果表明脑脊液漏的原因是有限的纵向硬脊膜裂口,可出现在硬脊膜腹侧、背侧或外侧。硬膜外病变,椎间盘微骨刺,是所有外侧腹脑脊液漏的单一原因。这些发现挑战了顽固性自发性颅内低压患者发生脑脊液漏是特发性的或由于硬脊膜较弱的概念,显微外科手术是治疗难治性顽固性自发性颅内低压的治疗选择。

原始出处:

Jürgen Beck,et al. Diskogenic microspurs as a major cause of intractable spontaneous
intracranial hypotension.
Neurology. 2016.Neurology. 

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    2017-06-05 yinhl1978
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    2016-09-28 sodoo