Am J Med:血清镁水平与CCU患者的死亡率有什么关系?

2016-09-26 Moon 译 MedSci原创

虽然电解质紊乱可能影响心肌动作电位,鲜为人知的是,血清镁和QTc间期的关系以及临床结果究竟如何? 研究纳入了2004年1月1日到2013年12月31日,连续收治的8498例入住梅奥诊所医院心脏监护病房(CCU)患者,有至少2次血清镁水平的数据记录。以探究血清镁水平与住院死亡率、心源性猝死和校正的QT间期(QTc)区间的联系。 患者年龄为67±15岁,62.2%是男性。CCU入院初步诊断

虽然电解质紊乱可能影响心肌动作电位,鲜为人知的是,血清镁和QTc间期的关系以及临床结果究竟如何?

研究纳入了2004年1月1日到2013年12月31日,连续收治的8498例入住梅奥诊所医院心脏监护病房(CCU)患者,有至少2次血清镁水平的数据记录。以探究血清镁水平与住院死亡率、心源性猝死和校正的QT间期(QTc)区间的联系。

患者年龄为67±15岁,62.2%是男性。CCU入院初步诊断:急性心肌梗死(50.7%)和急性失代偿性心力衰竭(42.5%)。更高血清镁水平的患者年龄更大、更可能是男性、并有更低的肾小球滤过率。

调整临床特点(包括肾脏疾病、血清钾)后的多因素分析显示,血清镁水平与QTc间期或心源性猝死无关。

与对照组相比(血清镁水平 2.0-<2.2mg/dL),入院时血清镁水平≥2.4mg/dL的患者,死亡率增加;入院时血清镁水平≥2.4mg/dL,是死亡率增加的独立因素;校正后的OR值为1.80(95% CI 1.25-2.59)。敏感性分析结果和排除肾衰竭、血钾异常患者后的分析结果是相似的。

这项回顾性研究,意外地观察到血清镁水平与QTc间期或心源性猝死之间没有关联。不过血清镁水平≥2.4mg/dL,是CCU患者死亡率增加的独立预测因素。

原始出处:


Naksuk N.et al.Association of Serum Magnesium on Mortality in Patients Admitted to the Intensive Cardiac Care Unit.Am J Med. 2016 Sep 14. pii: S0002-9343(16)30920-2. doi: 10.1016/j.amjmed.2016.08.033. [Epub ahead of print]

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    2016-10-03 1e0ece0dm09(暂无匿称)

    学习了谢谢

    0

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    2016-09-27 医路开来

    谢谢分享,,,

    0

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    2016-09-27 医路开来

    学习啦,,

    0

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    2016-09-27 医路开来

    电解质紊乱可能影响心肌动作电位

    0

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    2016-09-27 刘煜

    学习新知识谢谢

    0

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    2016-09-26 lovetcm

    门冬氨酸钾镁有效

    0

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