Prev Med：抑郁症状或可影响10年内急性冠脉综合征发生率

2016-05-12 MedSci MedSci原创

一项发表于preventive medicine的研究发现，急性冠脉综合征(ACS)患者合并严重抑郁状态可显著增加其10年内心血管疾病(CVD)的发生率。该研究为前瞻性多中心研究，连续纳入自2003年10月至2004年9月就诊于6家希腊医院的2172名ACS患者，进行为期10年的随访。使用经过验证的CES-D评分量表(0-60分)评估抑郁症状，通过地中海饮食评分(MedDietScore，0-55

一项发表于preventive medicine的研究发现，急性冠脉综合征(ACS)患者合并严重抑郁状态可显著增加其10年内心血管疾病(CVD)的发生率。

该研究为前瞻性多中心研究，连续纳入自2003年10月至2004年9月就诊于6家希腊医院的2172名ACS患者，进行为期10年的随访。使用经过验证的CES-D评分量表(0-60分)评估抑郁症状，通过地中海饮食评分(MedDietScore，0-55分)评估地中海式饮食依从性，财务状况由年收入确定。

Notara V博士等人根据CES-D评分结果将患者分为无抑郁、轻度抑郁、重度抑郁3组，研究结果显示，各组致死/非致死性ACS复发率分别为33%，37%和42%(P = 0.006)。多元Logistic回归模型表明，相比无抑郁组，重度抑郁组与10年致死/非致死性ACS事件相关[比值比(OR)=1.31, 95%CI 1.01-1.69]。经校正患者财务状况，抑郁症与ACS预后间的关联仍显著存在，亚组分析结果表明，仅对低/中收入患者造成负面影响(OR =1.36，95%CI 0.98-1.88)。通过MedDietScore得分进一步分层分析，结果表明，上述关联只在地中海饮食依从性低的患者中显著存在(OR = 1.68，95%CI 1.10-2.18)。

研究结果表明，ACS患者合并严重抑郁症状态或可导致不良疾病预后，财务状况与地中海饮食可能是潜在的调节因素。研究人员指出，公共卫生项目应重点关注易感群体，通过适当的药物治疗与生活方式进行干预，以便尽可能的改善抑郁症状，从而在临床以及社区层面改善疾病的预后情况。

原始出处：

Notara V, Panagiotakos DB, Tsompanaki E, Kouvari M, Kogias Y, Papanagnou G, Antonoulas A, Stravopodis P, Zombolos S, Stergiouli I, Mantas Y, Babatsikou F, Pitsavos C; GREECS Study Investigators, Greece. Depressive symptomatology in relation to 10-year (2004-2014) acute coronary syndrome incidence; the moderating role of diet and financial status. Prev Med. 2016 May;86:6-11

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2016-10-06 1e10c84am36(暂无匿称)

文章真心很好，感谢作者

61 0
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2016-08-01 一叶知秋

#发生率#

23 0
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2016-05-14 zhouqu_8

#综合征#

26 0
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2016-05-14 zhouqu_8

#抑郁症状#

36 0
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2016-05-14 ms3994565386320060

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