Atherosclerosis:心-踝血管指数预测肥胖患者心血管事件的发生

2015-08-25 MedSci MedSci原创

目的:心-踝血管指数(CAVI)是不依赖于动脉血压的一项显示动脉硬化的指标,是评估动脉功能障碍的指标。然而,CAVI是否能够预测肥胖病人的心脑血管疾病(CVD)的预后尚不清楚。方法:日本肥胖和代谢综合征研究中心招募425名日本肥胖门诊病人(189名男性,平均年龄51.5岁),进行一项多中心前瞻性群体研究。首先,进行包括CAVI等指标的心血管危险因素的监测,进行为期五年的随访确定患者大血管并发症的发

目的:心-踝血管指数(Cardio-ankle vascular index,CAVI)是不依赖于动脉血压的一项显示动脉硬化的指标,是评估动脉功能障碍的指标。然而,CAVI是否能够预测肥胖病人的心脑血管疾病(CVD)的预后尚不清楚。

方法:日本肥胖和代谢综合征研究中心招募425名日本肥胖门诊病人(189名男性,平均年龄51.5岁),进行一项多中心前瞻性群体研究。首先,进行包括CAVI等指标的心血管危险因素的监测,进行为期五年的随访确定患者大血管并发症的发生。

结果:所有的患者中,300名(78%)的患者随访五年。在研究期间,15名患有冠状动脉心脏病,7名患有卒中,6名患者出现闭塞性动脉硬化,CVD发生率为每年1.58%。在传统危险因素校正模型的分析中,CAVI是预测心血管事件的发生的危险因子。在Cox多变量分析中,校正年龄和性别后,发现较高的CAVI和较低的HDL水平(CAVI [per 1]: HR = 1.44 [1.02-2.02]; HDL [per 1 mmol/L]: HR = 0.20 [0.06-0.69])是预测心血管事件发生的危险因素。另外,CAVI增加预测CVD发生的粥样硬化性心血管疾病的危险分数。

结论:本研究第一次发现CAVI是肥胖患者CVD事件的有效预测因子。

原文出处:

Satoh-Asahara N, Kotani K, Yamakage H, et al. Cardio-ankle vascular index predicts for the incidence of cardiovascular events in obese patients: A multicenter prospective cohort study (Japan Obesity and Metabolic Syndrome Study: JOMS). Atherosclerosis. 2015 Aug 8;242(2):461-468. 


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    2015-08-27 lsndxfj

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