Am J Psychiat:长期使用抗精神病药:弊大于利?

2017-05-06 佚名 来宝网

数以百万计的美国人患有精神分裂症和其他严重的精神障碍。他们当中的许多人都在用抗精神病药物来控制症状,但是抗精神病药物的弊大于利?一项最新研究对此进行了调查研究。

数以百万计的美国人患有精神分裂症和其他严重的精神障碍。他们当中的许多人都在用抗精神病药物来控制症状,但是抗精神病药物的弊大于利?一项最新研究对此进行了调查研究。

超过350万的美国成年人(即美国人口的1.1%)患有精神分裂症。此外,据估计,在美国,每一年大约都有980万人患上严重的精神疾病以致严重扰乱了他们的日常生活。

目前还不知道是什么原因会导致精神分裂症,但其治疗方案——如抗精神病药物治疗和心理社会疗法——可用于精神分裂症患者控制他们的症状。在美国,大约有700万人通过服用抗精神病药物来治疗精神分裂症和其他类似的疾病。

然而,最近有一些研究表明,抗精神病药物可能弊大于利,尤其长期使用时。一些研究人员对这些药物的毒性作用表示担忧,他们提出患者只能短期服用此类药物。

以纽约哥伦比亚大学学院精神病学主席Lawrence C Kolb教授及Jeffrey Lieberman博士为首的研究小组调查了抗精神病药物对精神分裂症患者大脑和行为的长期影响。

这项最新研究成果发表在《美国精神病学杂志》上。

Lieberman及其研究小组通过对神经科学数据和临床试验发现,抗精神病药物治疗的好处远远大于其副作用。

“来自随机临床试验和神经影像学研究的证据压倒性地表明,大多数精神分裂症患者受益于抗精神病药物治疗,无论是疾病之初还是长期服用以防复发。”Jeffrey Lieberman博士如是说。

根据这项最新研究,推迟抗精神病药物治疗或是不给药与患者的长期负作用有关。

“虽然还需要更多的研究来解决这些问题,最强有力的证据支持抗精神病药物的好处,精神分裂症患者及其家人应该明确这一点,同时,他们应该明智而审慎地使用抗精神病药物,” Lieberman博士如是说。

原始出处:

Donald C.Goff, et al. The Long-Term Effects of Antipsychotic Medication on Clinical Course in Schizophrenia. American Journal of Psychiatry,Published online: May 5, 2017

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    2017-05-07 明天会更好!

    学习过了,分享分享!

    0

  4. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Sat May 06 06:45:16 CST 2017, time=2017-05-06, status=1, ipAttribution=)]
    2017-05-06 医张生

    需要长期服药。

    0

  5. 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    2017-05-06 cqykthl

    严重的精神疾病以致严重扰乱日常生活

    0

  6. 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    2017-05-06 1ddf0692m34(暂无匿称)

    任何药物都有其副作用

    0

  7. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Sat May 06 06:45:16 CST 2017, time=2017-05-06, status=1, ipAttribution=)]
    2017-05-06 skywangxs

    间断用药或停药于生命和生活质量更恶劣孰轻孰重?

    0

  8. 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    2017-05-06 明月清辉

    谢谢分享,学习了

    0

  9. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Sat May 06 06:45:16 CST 2017, time=2017-05-06, status=1, ipAttribution=)]
    2017-05-06 执着追梦

    学习,涨知识!

    0

  10. 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    2017-05-06 ren1mw

    美国的研究表明,抗精神病药物可能弊大于利

    0