Braz J Cardiovasc Surg:轻度术前肾功能不全患者冠状动脉搭桥术后的结果

2020-03-02 不详 网络

术前肾功能不全是冠状动脉搭桥术(CABG)术后死亡率的独立预测指标。但是,少有研究评估轻度术前肾功能不全对孤立的CABG手术后长期随访结果的影响。本研究旨在探究轻度术前肾功能不全对CABG患者长期随访结果的影响。研究人员回顾性分析了2009年1月1日至2016年12月1日接受CABG的584例患者的数据。他们分为两组:正常组[估计肾小球滤过率(eGFR)≥90 ml/min/1.73 m2,n =

术前肾功能不全是冠状动脉搭桥术(CABG)术后死亡率的独立预测指标。但是,少有研究评估轻度术前肾功能不全对孤立的CABG手术后长期随访结果的影响。本研究旨在探究轻度术前肾功能不全对CABG患者长期随访结果的影响。

研究人员回顾性分析了2009年1月1日至2016年12月1日接受CABG的584例患者的数据。他们分为两组:正常组[估计肾小球滤过率(eGFR)≥90 ml/min/1.73 m2,n = 304]和轻度组(eGFR在60至89 ml/min/1.73 m2,n = 280)。比较两组的临床资料和长期随访结果。

结果显示,除eGFR外,两组的基线和术中数据相似。长期随访发现,住院死亡6例(0.01%),正常组15例,轻度组28例,差异有统计学意义(P <0.05)。单因素分析表明,两组的住院结局相似。与轻度术前肾功能不全相比,Kaplan-Meier曲线显示术前肾功能正常的患者的长期生存期更好(x 2 = 4.255,P = 0.039)。 Cox比例模型显示轻度术前肾功能不全患者的长期死亡率与术前正常肾功能的危险比为1.79(95%CI 1.17-2.88,P = 0.027)。

总之,在长期生存中,轻度术前肾功能不全的患者的死亡率高于正常患者,而没有发现住院期间死亡率更差的证据。轻度术前肾功能不全的患者显示出比其他研究更高的死亡率。

原始出处:

Weitie Wang, Yuefeng Wang, et al., Outcomes Following Coronary Artery Bypass Graft Surgery in Patients with Mild Preoperative Renal Insufficiency. Braz J Cardiovasc Surg. 2018 Mar-Apr; 33(2): 155–161.

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    2020-09-08 yese
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    2020-10-30 quxin068
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    2020-03-03 zzc2214