AACR2013:他汀类药物可显著降低乳腺癌死亡率

2013-05-07 AACR2013 dxy

一项大型数据库研究显示,在乳腺癌诊断前后使用他汀类药物可使乳腺癌死亡风险降低66%。在美国癌症研究协会(AACR)2013年会上该研究的作者Teemu Murtola医生报道说即使在控制年龄、肿瘤分期、以及形态学特征和初治方案等因素后发现风险减少的趋势依然不变。 约翰霍普金斯大学的流行病学家Teemu J. Murtola医生及其同事指出,“在他汀类药物使用者人群中,我们观察到乳腺癌死亡风险存在

一项大型数据库研究显示,在乳腺癌诊断前后使用他汀类药物可使乳腺癌死亡风险降低66%。在美国癌症研究协会(AACR)2013年会上该研究的作者Teemu Murtola医生报道说即使在控制年龄、肿瘤分期、以及形态学特征和初治方案等因素后发现风险减少的趋势依然不变。 约翰霍普金斯大学的流行病学家Teemu J. Murtola医生及其同事指出,“在他汀类药物使用者人群中,我们观察到乳腺癌死亡风险存在清晰的剂量依赖性减少趋势,”这一人群占研究所纳入的超过31000例女性的13%。“而且无论是局部还是转移性癌症患者均存在这一关联。这一领域值得深入探索,这些发现为进一步的研究提供了绝好的理由。” 试验随访期间,研究者发现共有6,011例女性死亡;3,169例死亡由乳腺癌引起。他汀类药物使用者的死亡率显著低于未使用者(7.5% vs. 21%)。校正分析发现,使用他汀类药物的局部乳腺癌患者的死亡风险比未使用者低67%[危险比(HR)=0.33],使用他汀类药物的转移癌患者的死亡风险比未使用者低48% (HR= 0.52)。该研究队列使用的所有他汀类药物均与乳腺癌死亡风险显著降低相关,这些药物包括辛

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    2013-05-09 10518094zz
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    2013-05-09 Luyuxie_14